New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes

This work was supported by the Spanish Ministerio de Economía, Industria y Competitividad (MINECO), Agencia Estatal de Investigación (AEI), and Fondo Europeo de Desarrollo Regional (FEDER) (Grants SAF2017-82813-C3-3-R to N.C. and R.R.-R. and PCI2018-092997/AEI to R.R.-R.). A.F. is granted with a fel...

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Authors: Fosch, Anna, Zagmutt, Sebastián, Casals i Farré, Núria, Rodríguez-Rodríguez, Rosalía
Format: article
Publication Date:2021
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/2644
Online Access:http://hdl.handle.net/20.500.12328/2644
https://dx.doi.org/10.3390/ijms22126186
Access Level:Open access
Keyword:Neurones SF1
Nucli hipotàlem ventromedial
Obesitat
Diabetis
Homeòstasi energètica
Homeòstasi de la glucosa
Neuronas SF1
Núcleo del hipotálamo ventromedial
Obesidad
Diabetes
Homeostasis energética
Homeostasis de la glucosa
SF1 neurons
Ventromedial hypothalamus nucleus
Obesity
Energy homeostasis
Glucose homeostasis
61
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spelling New insights of SF1 neurons in hypothalamic regulation of obesity and diabetesFosch, AnnaZagmutt, SebastiánCasals i Farré, NúriaRodríguez-Rodríguez, RosalíaNeurones SF1Nucli hipotàlem ventromedialObesitatDiabetisHomeòstasi energèticaHomeòstasi de la glucosaNeuronas SF1Núcleo del hipotálamo ventromedialObesidadDiabetesHomeostasis energéticaHomeostasis de la glucosaSF1 neuronsVentromedial hypothalamus nucleusObesityDiabetesEnergy homeostasisGlucose homeostasis61This work was supported by the Spanish Ministerio de Economía, Industria y Competitividad (MINECO), Agencia Estatal de Investigación (AEI), and Fondo Europeo de Desarrollo Regional (FEDER) (Grants SAF2017-82813-C3-3-R to N.C. and R.R.-R. and PCI2018-092997/AEI to R.R.-R.). A.F. is granted with a fellowship from the Agència de Gestió d’Ajuts Universitaris i de la Recerca (AGAUR) in Catalonia.Despite the substantial role played by the hypothalamus in the regulation of energy balance and glucose homeostasis, the exact mechanisms and neuronal circuits underlying this regulation remain poorly understood. In the last 15 years, investigations using transgenic models, optogenetic, and chemogenetic approaches have revealed that SF1 neurons in the ventromedial hypothalamus are a specific lead in the brain’s ability to sense glucose levels and conduct insulin and leptin signaling in energy expenditure and glucose homeostasis, with minor feeding control. Deletion of hormonal receptors, nutritional sensors, or synaptic receptors in SF1 neurons triggers metabolic alterations mostly appreciated under high-fat feeding, indicating that SF1 neurons are particularly important for metabolic adaptation in the early stages of obesity. Although these studies have provided exciting insight into the implications of hypothalamic SF1 neurons on whole-body energy homeostasis, new questions have arisen from these results. Particularly, the existence of neuronal sub-populations of SF1 neurons and the intricate neurocircuitry linking these neurons with other nuclei and with the periphery. In this review, we address the most relevant studies carried out in SF1 neurons to date, to provide a global view of the central role played by these neurons in the pathogenesis of obesity and diabetes.info:eu-repo/semantics/publishedVersionMDPI2021info:eu-repo/semantics/article22http://hdl.handle.net/20.500.12328/2644https://dx.doi.org/10.3390/ijms22126186reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInternational Journal of Molecular Sciences22;12info:eu-repo/​grantAgreement/ES/2PE/SAF2017-82813-C3-3Rinfo:eu-repo/​grantAgreement/ES/2PE/PCI2018-092997/AEIThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/26442026-05-29T05:05:01Z
dc.title.none.fl_str_mv New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes
title New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes
spellingShingle New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes
Fosch, Anna
Neurones SF1
Nucli hipotàlem ventromedial
Obesitat
Diabetis
Homeòstasi energètica
Homeòstasi de la glucosa
Neuronas SF1
Núcleo del hipotálamo ventromedial
Obesidad
Diabetes
Homeostasis energética
Homeostasis de la glucosa
SF1 neurons
Ventromedial hypothalamus nucleus
Obesity
Diabetes
Energy homeostasis
Glucose homeostasis
61
title_short New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes
title_full New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes
title_fullStr New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes
title_full_unstemmed New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes
title_sort New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes
dc.creator.none.fl_str_mv Fosch, Anna
Zagmutt, Sebastián
Casals i Farré, Núria
Rodríguez-Rodríguez, Rosalía
author Fosch, Anna
author_facet Fosch, Anna
Zagmutt, Sebastián
Casals i Farré, Núria
Rodríguez-Rodríguez, Rosalía
author_role author
author2 Zagmutt, Sebastián
Casals i Farré, Núria
Rodríguez-Rodríguez, Rosalía
author2_role author
author
author
dc.subject.none.fl_str_mv Neurones SF1
Nucli hipotàlem ventromedial
Obesitat
Diabetis
Homeòstasi energètica
Homeòstasi de la glucosa
Neuronas SF1
Núcleo del hipotálamo ventromedial
Obesidad
Diabetes
Homeostasis energética
Homeostasis de la glucosa
SF1 neurons
Ventromedial hypothalamus nucleus
Obesity
Diabetes
Energy homeostasis
Glucose homeostasis
61
topic Neurones SF1
Nucli hipotàlem ventromedial
Obesitat
Diabetis
Homeòstasi energètica
Homeòstasi de la glucosa
Neuronas SF1
Núcleo del hipotálamo ventromedial
Obesidad
Diabetes
Homeostasis energética
Homeostasis de la glucosa
SF1 neurons
Ventromedial hypothalamus nucleus
Obesity
Diabetes
Energy homeostasis
Glucose homeostasis
61
description This work was supported by the Spanish Ministerio de Economía, Industria y Competitividad (MINECO), Agencia Estatal de Investigación (AEI), and Fondo Europeo de Desarrollo Regional (FEDER) (Grants SAF2017-82813-C3-3-R to N.C. and R.R.-R. and PCI2018-092997/AEI to R.R.-R.). A.F. is granted with a fellowship from the Agència de Gestió d’Ajuts Universitaris i de la Recerca (AGAUR) in Catalonia.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/2644
https://dx.doi.org/10.3390/ijms22126186
url http://hdl.handle.net/20.500.12328/2644
https://dx.doi.org/10.3390/ijms22126186
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Sciences
22;12
info:eu-repo/​grantAgreement/ES/2PE/SAF2017-82813-C3-3R
info:eu-repo/​grantAgreement/ES/2PE/PCI2018-092997/AEI
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 22
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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