The LRRC8-mediated volume-regulated anion channel is altered in glaucoma
LRRC8; Anion channel; Glaucoma
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/4086 |
| Acceso en línea: | https://hdl.handle.net/11351/4086 |
| Access Level: | acceso abierto |
| Palabra clave: | Glaucoma - Fisiologia patològica Anions - Metabolisme Proteïnes de membrana - Metabolisme DISEASES::Eye Diseases::Ocular Hypertension::Glaucoma Other subheadings::Other subheadings::Other subheadings::/physiopathology CHEMICALS AND DRUGS::Inorganic Chemicals::Electrolytes::Ions::Anions Other subheadings::Other subheadings::Other subheadings::/metabolism CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins ENFERMEDADES::oftalmopatías::hipertensión ocular::glaucoma Otros calificadores::Otros calificadores::Otros calificadores::/fisiopatología COMPUESTOS QUÍMICOS Y DROGAS::compuestos inorgánicos::electrólitos::iones::aniones Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de membranas |
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The LRRC8-mediated volume-regulated anion channel is altered in glaucomaGasull, XavierCastany Aregall, MartaCastellanos, AidaRezola, MikelAndrés-Bilbé, AlbaCanut, Maria IsabelGlaucoma - Fisiologia patològicaAnions - MetabolismeProteïnes de membrana - MetabolismeDISEASES::Eye Diseases::Ocular Hypertension::GlaucomaOther subheadings::Other subheadings::Other subheadings::/physiopathologyCHEMICALS AND DRUGS::Inorganic Chemicals::Electrolytes::Ions::AnionsOther subheadings::Other subheadings::Other subheadings::/metabolismCHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Membrane ProteinsENFERMEDADES::oftalmopatías::hipertensión ocular::glaucomaOtros calificadores::Otros calificadores::Otros calificadores::/fisiopatologíaCOMPUESTOS QUÍMICOS Y DROGAS::compuestos inorgánicos::electrólitos::iones::anionesOtros calificadores::Otros calificadores::Otros calificadores::/metabolismoCOMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de membranasLRRC8; Anion channel; GlaucomaLRRC8; Canal Aniònic; GlaucomaLRRC8; Canal Aniónico; GlaucomaRegulation of cellular volume is an essential process to balance volume changes during cell proliferation and migration or when intracellular osmolality increases due to transepithelial transport. We previously characterized the key role of volume-regulated anion channels (VRAC) in the modulation of the volume of trabecular meshwork (TM) cells and, in turn, the aqueous humour (AH) outflow from the eye. The balance between the secretion and the drainage of AH determines the intraocular pressure (IOP) that is the major casual risk factor for glaucoma. Glaucoma is an ocular disease that causes irreversible blindness due to the degeneration of retinal ganglion cells. The recent identification of Leucine-Rich Repeat-Containing 8 (LRRC8A-E) proteins as the molecular components of VRAC opens the field to elucidate their function in the physiology of TM and glaucoma. Human TM cells derived from non-glaucomatous donors and from open-angle glaucoma patients were used to determine the expression and the functional activity of LRRC8-mediated channels. Expression levels of LRRC8A-E subunits were decreased in HTM glaucomatous cells compared to normotensive HTM cells. Consequently, the activity of VRAC currents and volume regulation of TM cells were significantly affected. Impaired cell volume regulation will likely contribute to altered aqueous outflow and intraocular pressure.Nature ResearchInstitut Català de la Salut[Gasull X, Castellanos A, Rezola M, Andrés-Bilbé A] Laboratori de Neurofisiologia, Unitat de Fisiologia, Departament de Biomedicina, Escola de Medicina, Universitat de Barcelona, Barcelona, Spain. Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. [Castany M] Servei de d’oftalmologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Canut MI] Institut Universitari Barraquer, Barcelona, Spain.Vall d'Hebron Barcelona Hospital Campus201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/4086Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésScientific Reports;9(1)https://www.nature.com/articles/s41598-019-41524-3Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/40862026-06-12T09:38:37Z |
| dc.title.none.fl_str_mv |
The LRRC8-mediated volume-regulated anion channel is altered in glaucoma |
| title |
The LRRC8-mediated volume-regulated anion channel is altered in glaucoma |
| spellingShingle |
The LRRC8-mediated volume-regulated anion channel is altered in glaucoma Gasull, Xavier Glaucoma - Fisiologia patològica Anions - Metabolisme Proteïnes de membrana - Metabolisme DISEASES::Eye Diseases::Ocular Hypertension::Glaucoma Other subheadings::Other subheadings::Other subheadings::/physiopathology CHEMICALS AND DRUGS::Inorganic Chemicals::Electrolytes::Ions::Anions Other subheadings::Other subheadings::Other subheadings::/metabolism CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins ENFERMEDADES::oftalmopatías::hipertensión ocular::glaucoma Otros calificadores::Otros calificadores::Otros calificadores::/fisiopatología COMPUESTOS QUÍMICOS Y DROGAS::compuestos inorgánicos::electrólitos::iones::aniones Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de membranas |
| title_short |
The LRRC8-mediated volume-regulated anion channel is altered in glaucoma |
| title_full |
The LRRC8-mediated volume-regulated anion channel is altered in glaucoma |
| title_fullStr |
The LRRC8-mediated volume-regulated anion channel is altered in glaucoma |
| title_full_unstemmed |
The LRRC8-mediated volume-regulated anion channel is altered in glaucoma |
| title_sort |
The LRRC8-mediated volume-regulated anion channel is altered in glaucoma |
| dc.creator.none.fl_str_mv |
Gasull, Xavier Castany Aregall, Marta Castellanos, Aida Rezola, Mikel Andrés-Bilbé, Alba Canut, Maria Isabel |
| author |
Gasull, Xavier |
| author_facet |
Gasull, Xavier Castany Aregall, Marta Castellanos, Aida Rezola, Mikel Andrés-Bilbé, Alba Canut, Maria Isabel |
| author_role |
author |
| author2 |
Castany Aregall, Marta Castellanos, Aida Rezola, Mikel Andrés-Bilbé, Alba Canut, Maria Isabel |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Gasull X, Castellanos A, Rezola M, Andrés-Bilbé A] Laboratori de Neurofisiologia, Unitat de Fisiologia, Departament de Biomedicina, Escola de Medicina, Universitat de Barcelona, Barcelona, Spain. Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. [Castany M] Servei de d’oftalmologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Canut MI] Institut Universitari Barraquer, Barcelona, Spain. Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Glaucoma - Fisiologia patològica Anions - Metabolisme Proteïnes de membrana - Metabolisme DISEASES::Eye Diseases::Ocular Hypertension::Glaucoma Other subheadings::Other subheadings::Other subheadings::/physiopathology CHEMICALS AND DRUGS::Inorganic Chemicals::Electrolytes::Ions::Anions Other subheadings::Other subheadings::Other subheadings::/metabolism CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins ENFERMEDADES::oftalmopatías::hipertensión ocular::glaucoma Otros calificadores::Otros calificadores::Otros calificadores::/fisiopatología COMPUESTOS QUÍMICOS Y DROGAS::compuestos inorgánicos::electrólitos::iones::aniones Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de membranas |
| topic |
Glaucoma - Fisiologia patològica Anions - Metabolisme Proteïnes de membrana - Metabolisme DISEASES::Eye Diseases::Ocular Hypertension::Glaucoma Other subheadings::Other subheadings::Other subheadings::/physiopathology CHEMICALS AND DRUGS::Inorganic Chemicals::Electrolytes::Ions::Anions Other subheadings::Other subheadings::Other subheadings::/metabolism CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins ENFERMEDADES::oftalmopatías::hipertensión ocular::glaucoma Otros calificadores::Otros calificadores::Otros calificadores::/fisiopatología COMPUESTOS QUÍMICOS Y DROGAS::compuestos inorgánicos::electrólitos::iones::aniones Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de membranas |
| description |
LRRC8; Anion channel; Glaucoma |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019 2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/4086 |
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https://hdl.handle.net/11351/4086 |
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Inglés |
| language_invalid_str_mv |
Inglés |
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Scientific Reports;9(1) https://www.nature.com/articles/s41598-019-41524-3 |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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Nature Research |
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Nature Research |
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Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
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Departament de Salut de la Generalitat de Catalunya (DS) |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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