Nanometric-Thick Metal-Free h-Boron Nitride/Graphene Films as Base Catalyst for the Synthesis of Benzoxazoles

Catalysts are frequently used as pelletized powdered materials, but rarely as thin films. The present work reports the use of 2D h-boron nitride on few layers defective graphene (h-BN/fl-G) films of about 10 nm thickness as base catalyst for the synthesis of benzoxazoles by coupling a 2-amino-phenol...

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Detalhes bibliográficos
Autores: Rendón-Patiño, Alejandra, Primo, Ana, Cojocaru, Bogdan, Gabriela Ion, Sabina, Popescu, Dana G., Parvulescu, Vasile, García Gómez, Hermenegildo
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/282549
Acesso em linha:http://hdl.handle.net/10261/282549
Access Level:acceso abierto
Descrição
Resumo:Catalysts are frequently used as pelletized powdered materials, but rarely as thin films. The present work reports the use of 2D h-boron nitride on few layers defective graphene (h-BN/fl-G) films of about 10 nm thickness as base catalyst for the synthesis of benzoxazoles by coupling a 2-amino-phenol with p-substituted benzaldehydes. The synthesis of benzoxazole derivatives has aroused much interest in the last decades due to their application as potent anticancer agents against MCF-7 and MDA-MB-231 breast cancer cells. The results demonstrate that these nanometer-thick films exhibit three orders of magnitude higher activity than KCO taken as benchmark base catalyst. The activity and selectivity of h-BN/fl-G films depend on the nature of substituents on benzaldehyde, the solvent and reaction temperature.

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