Yeast-to-hypha transition of schizosaccharomyces japonicus in response to environmental stimuli

Many fungal species are dimorphic, exhibiting both unicellular yeast-like and filamentous forms. Schizosaccharomyces japonicus, a member of the fission yeast clade, is one such dimorphic fungus. Here, we first identify fruit extracts as natural, stress-free, starvation-independent inducers of filame...

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Autores: Kinnaer, Cassandre, Dudin, Omaya, Martin, Sophie G., Lew, Daniel J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/55282
Acceso en línea:http://hdl.handle.net/10230/55282
http://dx.doi.org/10.1091/mbc.E18-12-0774
Access Level:acceso abierto
Palabra clave:Fongs -- Espècimens tipus
Plantes -- Cèl·lules i teixits
Cèl·lules
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spelling Yeast-to-hypha transition of schizosaccharomyces japonicus in response to environmental stimuliKinnaer, CassandreDudin, OmayaMartin, Sophie G.Lew, Daniel J.Fongs -- Espècimens tipusPlantes -- Cèl·lules i teixitsCèl·lulesMany fungal species are dimorphic, exhibiting both unicellular yeast-like and filamentous forms. Schizosaccharomyces japonicus, a member of the fission yeast clade, is one such dimorphic fungus. Here, we first identify fruit extracts as natural, stress-free, starvation-independent inducers of filamentation, which we use to describe the properties of the dimorphic switch. During the yeast-to-hypha transition, the cell evolves from a bipolar to a unipolar system with 10-fold accelerated polarized growth but constant width, vacuoles segregated to the nongrowing half of the cell, and hyper-lengthening of the cell. We demonstrate unusual features of S. japonicus hyphae: these cells lack a Spitzenkörper, a vesicle distribution center at the hyphal tip, but display more rapid cytoskeleton-based transport than the yeast form, with actin cables being essential for the transition. S. japonicus hyphae also remain mononuclear and undergo complete cell divisions, which are highly asymmetric: one daughter cell inherits the vacuole, the other the growing tip. We show that these elongated cells scale their nuclear size, spindle length, and elongation rates, but display altered division size controls. This establishes S. japonicus as a unique system that switches between symmetric and asymmetric modes of growth and division.American Society for Cell Biology202320232019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/55282http://dx.doi.org/10.1091/mbc.E18-12-0774reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésMolecular Biology of the Cell. 2019 Apr 01;30(8):975-91© 2019 Kinnaer et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).http://creativecommons.org/licenses/by-nc-sa/3.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/552822026-05-29T05:05:01Z
dc.title.none.fl_str_mv Yeast-to-hypha transition of schizosaccharomyces japonicus in response to environmental stimuli
title Yeast-to-hypha transition of schizosaccharomyces japonicus in response to environmental stimuli
spellingShingle Yeast-to-hypha transition of schizosaccharomyces japonicus in response to environmental stimuli
Kinnaer, Cassandre
Fongs -- Espècimens tipus
Plantes -- Cèl·lules i teixits
Cèl·lules
title_short Yeast-to-hypha transition of schizosaccharomyces japonicus in response to environmental stimuli
title_full Yeast-to-hypha transition of schizosaccharomyces japonicus in response to environmental stimuli
title_fullStr Yeast-to-hypha transition of schizosaccharomyces japonicus in response to environmental stimuli
title_full_unstemmed Yeast-to-hypha transition of schizosaccharomyces japonicus in response to environmental stimuli
title_sort Yeast-to-hypha transition of schizosaccharomyces japonicus in response to environmental stimuli
dc.creator.none.fl_str_mv Kinnaer, Cassandre
Dudin, Omaya
Martin, Sophie G.
Lew, Daniel J.
author Kinnaer, Cassandre
author_facet Kinnaer, Cassandre
Dudin, Omaya
Martin, Sophie G.
Lew, Daniel J.
author_role author
author2 Dudin, Omaya
Martin, Sophie G.
Lew, Daniel J.
author2_role author
author
author
dc.subject.none.fl_str_mv Fongs -- Espècimens tipus
Plantes -- Cèl·lules i teixits
Cèl·lules
topic Fongs -- Espècimens tipus
Plantes -- Cèl·lules i teixits
Cèl·lules
description Many fungal species are dimorphic, exhibiting both unicellular yeast-like and filamentous forms. Schizosaccharomyces japonicus, a member of the fission yeast clade, is one such dimorphic fungus. Here, we first identify fruit extracts as natural, stress-free, starvation-independent inducers of filamentation, which we use to describe the properties of the dimorphic switch. During the yeast-to-hypha transition, the cell evolves from a bipolar to a unipolar system with 10-fold accelerated polarized growth but constant width, vacuoles segregated to the nongrowing half of the cell, and hyper-lengthening of the cell. We demonstrate unusual features of S. japonicus hyphae: these cells lack a Spitzenkörper, a vesicle distribution center at the hyphal tip, but display more rapid cytoskeleton-based transport than the yeast form, with actin cables being essential for the transition. S. japonicus hyphae also remain mononuclear and undergo complete cell divisions, which are highly asymmetric: one daughter cell inherits the vacuole, the other the growing tip. We show that these elongated cells scale their nuclear size, spindle length, and elongation rates, but display altered division size controls. This establishes S. japonicus as a unique system that switches between symmetric and asymmetric modes of growth and division.
publishDate 2019
dc.date.none.fl_str_mv 2019
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/55282
http://dx.doi.org/10.1091/mbc.E18-12-0774
url http://hdl.handle.net/10230/55282
http://dx.doi.org/10.1091/mbc.E18-12-0774
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Molecular Biology of the Cell. 2019 Apr 01;30(8):975-91
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-sa/3.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Cell Biology
publisher.none.fl_str_mv American Society for Cell Biology
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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