The complex HLA-E-nonapeptide in Behçet disease
Behçet disease; NK cells; Gene association
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/10318 |
| Acceso en línea: | https://hdl.handle.net/11351/10318 http://hdl.handle.net/11351/10318 |
| Access Level: | acceso abierto |
| Palabra clave: | Antígens HLA Behçet, Malaltia de - Aspectes genètics CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class I::HLA-A Antigens DISEASES::Cardiovascular Diseases::Vascular Diseases::Vasculitis::Behcet Syndrome Other subheadings::Other subheadings::Other subheadings::/genetics COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::glicoproteínas::glicoproteínas de membranas::antígenos de histocompatibilidad de clase I::antígenos HLA-A ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::vasculitis::síndrome de Behçet Otros calificadores::Otros calificadores::Otros calificadores::/genética |
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| dc.title.none.fl_str_mv |
The complex HLA-E-nonapeptide in Behçet disease |
| title |
The complex HLA-E-nonapeptide in Behçet disease |
| spellingShingle |
The complex HLA-E-nonapeptide in Behçet disease Castaño Núñez, Angel Luis Antígens HLA Behçet, Malaltia de - Aspectes genètics CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class I::HLA-A Antigens DISEASES::Cardiovascular Diseases::Vascular Diseases::Vasculitis::Behcet Syndrome Other subheadings::Other subheadings::Other subheadings::/genetics COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::glicoproteínas::glicoproteínas de membranas::antígenos de histocompatibilidad de clase I::antígenos HLA-A ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::vasculitis::síndrome de Behçet Otros calificadores::Otros calificadores::Otros calificadores::/genética |
| title_short |
The complex HLA-E-nonapeptide in Behçet disease |
| title_full |
The complex HLA-E-nonapeptide in Behçet disease |
| title_fullStr |
The complex HLA-E-nonapeptide in Behçet disease |
| title_full_unstemmed |
The complex HLA-E-nonapeptide in Behçet disease |
| title_sort |
The complex HLA-E-nonapeptide in Behçet disease |
| dc.creator.none.fl_str_mv |
Castaño Núñez, Angel Luis Montes-Cano, Marco Antonio García-Lozano, José-Raúl Ortego-Centeno, Norberto Garcia-Hernandez, Francisco Jose Espinosa, Gerard Solans-Laque, Roser |
| author |
Castaño Núñez, Angel Luis |
| author_facet |
Castaño Núñez, Angel Luis Montes-Cano, Marco Antonio García-Lozano, José-Raúl Ortego-Centeno, Norberto Garcia-Hernandez, Francisco Jose Espinosa, Gerard Solans-Laque, Roser |
| author_role |
author |
| author2 |
Montes-Cano, Marco Antonio García-Lozano, José-Raúl Ortego-Centeno, Norberto Garcia-Hernandez, Francisco Jose Espinosa, Gerard Solans-Laque, Roser |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Castaño-Núñez ÁL, Montes-Cano MA, García-Lozano JR] Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), Sevilla, Spain. [Ortego-Centeno N] Department of Internal Medicine, Hospital Clínico San Cecilio, Granada, Spain. [García-Hernández FJ] Department of Internal Medicine, Hospital Universitario Virgen del Rocío, Sevilla, Spain. [Espinosa G] Department Autoimmune Diseases, Hospital Universitari Clínic, Barcelona, Spain. [Solans R] Servei de Medicina Interna, Unitat de Malalties Autoimmunes Sistèmiques, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Antígens HLA Behçet, Malaltia de - Aspectes genètics CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class I::HLA-A Antigens DISEASES::Cardiovascular Diseases::Vascular Diseases::Vasculitis::Behcet Syndrome Other subheadings::Other subheadings::Other subheadings::/genetics COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::glicoproteínas::glicoproteínas de membranas::antígenos de histocompatibilidad de clase I::antígenos HLA-A ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::vasculitis::síndrome de Behçet Otros calificadores::Otros calificadores::Otros calificadores::/genética |
| topic |
Antígens HLA Behçet, Malaltia de - Aspectes genètics CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class I::HLA-A Antigens DISEASES::Cardiovascular Diseases::Vascular Diseases::Vasculitis::Behcet Syndrome Other subheadings::Other subheadings::Other subheadings::/genetics COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::glicoproteínas::glicoproteínas de membranas::antígenos de histocompatibilidad de clase I::antígenos HLA-A ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::vasculitis::síndrome de Behçet Otros calificadores::Otros calificadores::Otros calificadores::/genética |
| description |
Behçet disease; NK cells; Gene association |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023 2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/10318 http://hdl.handle.net/11351/10318 |
| url |
https://hdl.handle.net/11351/10318 http://hdl.handle.net/11351/10318 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Frontiers in Immunology;14 https://doi.org/10.3389/fimmu.2023.1080047 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
| publisher.none.fl_str_mv |
Frontiers Media |
| dc.source.none.fl_str_mv |
Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| repository.name.fl_str_mv |
|
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|
| _version_ |
1869408189979557888 |
| spelling |
The complex HLA-E-nonapeptide in Behçet diseaseCastaño Núñez, Angel LuisMontes-Cano, Marco AntonioGarcía-Lozano, José-RaúlOrtego-Centeno, NorbertoGarcia-Hernandez, Francisco JoseEspinosa, GerardSolans-Laque, RoserAntígens HLABehçet, Malaltia de - Aspectes genèticsCHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class I::HLA-A AntigensDISEASES::Cardiovascular Diseases::Vascular Diseases::Vasculitis::Behcet SyndromeOther subheadings::Other subheadings::Other subheadings::/geneticsCOMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::glicoproteínas::glicoproteínas de membranas::antígenos de histocompatibilidad de clase I::antígenos HLA-AENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::vasculitis::síndrome de BehçetOtros calificadores::Otros calificadores::Otros calificadores::/genéticaBehçet disease; NK cells; Gene associationMalaltia de Behçet; Cèl·lules NK; Associació de gensEnfermedad de Behçet; Células NK; Asociación genéticaIntroduction: The knowledge of the aetiology of Behçet disease (BD), an immune-mediated vasculitis, is limited. HLA-B, mainly HLA-B51, and HLA-A molecules are associated with disease, but the ultimate cause of this association remains obscure. There is evidence that NK cells participate in the etiopathology of BD. NK cells have activator and inhibitor surface receptors, like the KIR and the NKG2 families. Classical HLA-class I molecules (A, B and C) are keys in the activity control of the NK because they are KIR ligands. Most NKG2 receptors bind HLA-E, which presents only nonapeptides derived from the signal peptide of other class-I molecules. Objective: This study investigates the contribution of the pair HLA-E and ligand, nonapeptide derived from the 3-11 sequence of the signal peptides of class I classical molecules, to the susceptibility to BD. Methods: We analyzed the frequency of the HLA-derivated nonapeptide forms in 466 BD patients and 444 controls and an HLA-E functional dimorphism in a subgroup of patients and controls. Results: In B51 negative patients, the frequency of VMAPRTLLL was lower (70.4% versus 80.0% in controls; P=0.006, Pc=0.04, OR=0.60, 95%CI 0.41-0.86), and the frequency of VMAPRTLVL was higher (81.6% versus 71.4% in controls; P=0.004, Pc=0.03, OR=1.78, 95%CI 1.20-2.63). In homozygosity, VMAPRTLLL is protective, and VMAPRTLVL confers risk. The heterozygous condition is neutral. There were no significant differences in the distribution of the HLA-E dimorphism. Discussion: Our results explain the association of BD with diverse HLA-A molecules, reinforce the hypothesis of the involvement of the NK cells in the disease and do not suggest a significant contribution of the HLA-E polymorphism to disease susceptibility.This work was supported by Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III (ISCIII PI16/01373 and PI19/00605), Fondos FEDER and Plan Andaluz de Investigación (CTS-0197).Frontiers MediaInstitut Català de la Salut[Castaño-Núñez ÁL, Montes-Cano MA, García-Lozano JR] Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), Sevilla, Spain. [Ortego-Centeno N] Department of Internal Medicine, Hospital Clínico San Cecilio, Granada, Spain. [García-Hernández FJ] Department of Internal Medicine, Hospital Universitario Virgen del Rocío, Sevilla, Spain. [Espinosa G] Department Autoimmune Diseases, Hospital Universitari Clínic, Barcelona, Spain. [Solans R] Servei de Medicina Interna, Unitat de Malalties Autoimmunes Sistèmiques, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/10318http://hdl.handle.net/11351/10318Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFrontiers in Immunology;14https://doi.org/10.3389/fimmu.2023.1080047Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/103182026-05-29T05:05:01Z |
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15.811543 |