Distribution of lesions in red and fallow deer naturally infected with Mycobacterium bovis

Wild deer have an important role in the epidemiology of bovine tuberculosis (bTB). The aims of this study were (1) to compare the pattern of lesions present in wild red (Cervus elaphus) and fallow (Dama dama) deer that were naturally infected with Mycobacterium bovis, and (2) to use this information...

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Autores: Martín-Hernando, Mari Paz, Torres-Sánchez, María José, Aznar Martín, Javier, Negro, Juan J., Gandía, A., Gortázar, Christian
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2010
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/38806
Acceso en línea:http://hdl.handle.net/10261/38806
Access Level:acceso abierto
Palabra clave:Bovine tuberculosis
Lymphoid tissue
Mycobacterium bovis
Wild deer
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spelling Distribution of lesions in red and fallow deer naturally infected with Mycobacterium bovisMartín-Hernando, Mari PazTorres-Sánchez, María JoséAznar Martín, JavierNegro, Juan J.Gandía, A.Gortázar, ChristianBovine tuberculosisLymphoid tissueMycobacterium bovisWild deerWild deer have an important role in the epidemiology of bovine tuberculosis (bTB). The aims of this study were (1) to compare the pattern of lesions present in wild red (Cervus elaphus) and fallow (Dama dama) deer that were naturally infected with Mycobacterium bovis, and (2) to use this information to develop a sampling strategy for the isolation of M. bovis from the lymphoid tissues of the head of these animals. Culture of head lymphoid tissues demonstrated that 28 of 95 red deer and 22 of 100 fallow deer sampled were infected with M. bovis. Approx- imately 30% of each deer population had no gross lesions. Fallow deer were significantly more likely to have thoracic lesions than red deer. Lesions were observed in the retropharyngeal lymph nodes of 64% of the culture-positive red deer and 43% of the culture positive fallow deer. One third of the red deer, but none of the fallow deer, had well-encapsulated abscess lesions. There were no microscopical differences in the lesions in the lymph nodes of the red and fallow deer. Bacteriological culture from both the tonsil and retro- pharyngeal lymph nodes increased the rate of isolation of M. bovis by 22% over culture of the retropharyngeal lymph nodes alone in both species. These findings indicate that investigation of wild deer for bTB-compatible lesions should include examination of the medial retropharyngeal, left tracheobronchial, mediastinal, mesen- teric and ileocaecal lymph nodes. Sampling for bacteriological culture from head lymphoid tissues should be from the tonsil and the medial retropharyngeal lymph nodes. These protocols may prove useful in bTB surveil- lance and control in regions where wild deer contribute to the circulation of M. bovis.This study was funded by Consejería de Medio Ambiente, Junta de Andalucía. This is a contribution to CICYT – MEC research grant AGL2008-03875 and FEDER, and to EU grant TB-STEP 212414. Studies on diseases shared between domestic animals and wildlife are also supported by grants and contracts from INIA, Principado de Asturias, Castilla – La Mancha (GC-006), Ministerio de Medio Ambiente y Medio Rural y Marino (OAPN and SDGSPP), and Grupo Santander – Fundacion Marcelino Botin. MPM-H acknowledges a post doctoral contract from the Instituto de Salud Carlos III.Peer reviewedElsevierJunta de AndalucíaEuropean CommissionComisión Interministerial de Ciencia y Tecnología, CICYT (España)Ministerio de Educación y Ciencia (España)CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)Junta de Comunidades de Castilla-La ManchaPrincipado de AsturiasMinisterio de Medio Ambiente y Medio Rural y Marino (España)Fundación BotínOrganismo Autónomo Parques Nacionales (España)Instituto de Salud Carlos IIIConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201120112010info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/38806reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/212414http://dx.doi.org/10.1016/j.jcpa.2009.07.003Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/388062026-05-22T06:33:51Z
dc.title.none.fl_str_mv Distribution of lesions in red and fallow deer naturally infected with Mycobacterium bovis
title Distribution of lesions in red and fallow deer naturally infected with Mycobacterium bovis
spellingShingle Distribution of lesions in red and fallow deer naturally infected with Mycobacterium bovis
Martín-Hernando, Mari Paz
Bovine tuberculosis
Lymphoid tissue
Mycobacterium bovis
Wild deer
title_short Distribution of lesions in red and fallow deer naturally infected with Mycobacterium bovis
title_full Distribution of lesions in red and fallow deer naturally infected with Mycobacterium bovis
title_fullStr Distribution of lesions in red and fallow deer naturally infected with Mycobacterium bovis
title_full_unstemmed Distribution of lesions in red and fallow deer naturally infected with Mycobacterium bovis
title_sort Distribution of lesions in red and fallow deer naturally infected with Mycobacterium bovis
dc.creator.none.fl_str_mv Martín-Hernando, Mari Paz
Torres-Sánchez, María José
Aznar Martín, Javier
Negro, Juan J.
Gandía, A.
Gortázar, Christian
author Martín-Hernando, Mari Paz
author_facet Martín-Hernando, Mari Paz
Torres-Sánchez, María José
Aznar Martín, Javier
Negro, Juan J.
Gandía, A.
Gortázar, Christian
author_role author
author2 Torres-Sánchez, María José
Aznar Martín, Javier
Negro, Juan J.
Gandía, A.
Gortázar, Christian
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Junta de Andalucía
European Commission
Comisión Interministerial de Ciencia y Tecnología, CICYT (España)
Ministerio de Educación y Ciencia (España)
CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)
Junta de Comunidades de Castilla-La Mancha
Principado de Asturias
Ministerio de Medio Ambiente y Medio Rural y Marino (España)
Fundación Botín
Organismo Autónomo Parques Nacionales (España)
Instituto de Salud Carlos III
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bovine tuberculosis
Lymphoid tissue
Mycobacterium bovis
Wild deer
topic Bovine tuberculosis
Lymphoid tissue
Mycobacterium bovis
Wild deer
description Wild deer have an important role in the epidemiology of bovine tuberculosis (bTB). The aims of this study were (1) to compare the pattern of lesions present in wild red (Cervus elaphus) and fallow (Dama dama) deer that were naturally infected with Mycobacterium bovis, and (2) to use this information to develop a sampling strategy for the isolation of M. bovis from the lymphoid tissues of the head of these animals. Culture of head lymphoid tissues demonstrated that 28 of 95 red deer and 22 of 100 fallow deer sampled were infected with M. bovis. Approx- imately 30% of each deer population had no gross lesions. Fallow deer were significantly more likely to have thoracic lesions than red deer. Lesions were observed in the retropharyngeal lymph nodes of 64% of the culture-positive red deer and 43% of the culture positive fallow deer. One third of the red deer, but none of the fallow deer, had well-encapsulated abscess lesions. There were no microscopical differences in the lesions in the lymph nodes of the red and fallow deer. Bacteriological culture from both the tonsil and retro- pharyngeal lymph nodes increased the rate of isolation of M. bovis by 22% over culture of the retropharyngeal lymph nodes alone in both species. These findings indicate that investigation of wild deer for bTB-compatible lesions should include examination of the medial retropharyngeal, left tracheobronchial, mediastinal, mesen- teric and ileocaecal lymph nodes. Sampling for bacteriological culture from head lymphoid tissues should be from the tonsil and the medial retropharyngeal lymph nodes. These protocols may prove useful in bTB surveil- lance and control in regions where wild deer contribute to the circulation of M. bovis.
publishDate 2010
dc.date.none.fl_str_mv 2010
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/38806
url http://hdl.handle.net/10261/38806
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/212414
http://dx.doi.org/10.1016/j.jcpa.2009.07.003
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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