The Role of Circulating Aβ Seeds in the Progression of Cerebral Amyloidosis.

While understudied, it is suspected that peripheral Aβ peptides affect Alzheimer's disease (AD)-associated pathological changes in the brain. The peripheral sink hypothesis postulates that the central and peripheral pools of Aβ co-exist in equilibrium. As such, cerebral amyloid levels may be mo...

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Detalhes bibliográficos
Autores: Gamez, Nazaret, Morales, Rodrigo
Tipo de documento: artigo
Data de publicação:2022
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositório:Repisalud
Idioma:inglês
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18815
Acesso em linha:http://hdl.handle.net/20.500.12105/18815
Access Level:Acceso aberto
Palavra-chave:Alzheimer’s disease
amyloid-beta
neurodegeneration
peripheral tissues
prion
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spelling The Role of Circulating Aβ Seeds in the Progression of Cerebral Amyloidosis.Gamez, NazaretMorales, RodrigoAlzheimer’s diseaseamyloid-betaneurodegenerationperipheral tissuesprionWhile understudied, it is suspected that peripheral Aβ peptides affect Alzheimer's disease (AD)-associated pathological changes in the brain. The peripheral sink hypothesis postulates that the central and peripheral pools of Aβ co-exist in equilibrium. As such, cerebral amyloid levels may be modulated by intervening circulating Aβ. In this commentary, we discuss relevant literature supporting the potential role of peripheral Aβ in exacerbating brain amyloidosis in both humans and mouse models of AD. Moreover, we highlight the need to further understand the mechanisms by which circulating Aβ peptides may reach the brain and contribute to neuropathology. Finally, we discuss the implications of targeting peripheral Aβ as a therapeutic approach in treating AD.20242024-02-2720222022-09-1520222022-09-15research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/18815reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/188152026-06-12T12:43:37Z
dc.title.none.fl_str_mv The Role of Circulating Aβ Seeds in the Progression of Cerebral Amyloidosis.
title The Role of Circulating Aβ Seeds in the Progression of Cerebral Amyloidosis.
spellingShingle The Role of Circulating Aβ Seeds in the Progression of Cerebral Amyloidosis.
Gamez, Nazaret
Alzheimer’s disease
amyloid-beta
neurodegeneration
peripheral tissues
prion
title_short The Role of Circulating Aβ Seeds in the Progression of Cerebral Amyloidosis.
title_full The Role of Circulating Aβ Seeds in the Progression of Cerebral Amyloidosis.
title_fullStr The Role of Circulating Aβ Seeds in the Progression of Cerebral Amyloidosis.
title_full_unstemmed The Role of Circulating Aβ Seeds in the Progression of Cerebral Amyloidosis.
title_sort The Role of Circulating Aβ Seeds in the Progression of Cerebral Amyloidosis.
dc.creator.none.fl_str_mv Gamez, Nazaret
Morales, Rodrigo
author Gamez, Nazaret
author_facet Gamez, Nazaret
Morales, Rodrigo
author_role author
author2 Morales, Rodrigo
author2_role author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Alzheimer’s disease
amyloid-beta
neurodegeneration
peripheral tissues
prion
topic Alzheimer’s disease
amyloid-beta
neurodegeneration
peripheral tissues
prion
description While understudied, it is suspected that peripheral Aβ peptides affect Alzheimer's disease (AD)-associated pathological changes in the brain. The peripheral sink hypothesis postulates that the central and peripheral pools of Aβ co-exist in equilibrium. As such, cerebral amyloid levels may be modulated by intervening circulating Aβ. In this commentary, we discuss relevant literature supporting the potential role of peripheral Aβ in exacerbating brain amyloidosis in both humans and mouse models of AD. Moreover, we highlight the need to further understand the mechanisms by which circulating Aβ peptides may reach the brain and contribute to neuropathology. Finally, we discuss the implications of targeting peripheral Aβ as a therapeutic approach in treating AD.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-09-15
2022
2022-09-15
2024
2024-02-27
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/18815
url http://hdl.handle.net/20.500.12105/18815
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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