Enhancing Boron Neutron Capture Therapy (BNCT) with Materials Based on COSAN-Functionalized Nanoparticles
<b>Background/Objectives</b>: Boron neutron capture therapy (BNCT) is a promising approach for selectively targeting and destroying malignant cells using <sup>10</sup>B isotopes. A significant challenge in BNCT lies in the development of efficient boron delivery systems that...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:dnet:digitalcsic_::3683a27e0edc54141d14792469c28e8f |
| Acceso en línea: | http://hdl.handle.net/10261/385746 |
| Access Level: | acceso abierto |
| Palabra clave: | Boron clusters BNCT Metallacarboranes C. elegans |
| Sumario: | <b>Background/Objectives</b>: Boron neutron capture therapy (BNCT) is a promising approach for selectively targeting and destroying malignant cells using <sup>10</sup>B isotopes. A significant challenge in BNCT lies in the development of efficient boron delivery systems that ensure adequate boron accumulation within tumor cells. This study aims to synthesize, characterize, and evaluate COSAN-functionalized nanoparticles (<b>NP@I-COSAN</b>) as a potential boron carrier for BNCT. <b>Methods</b>: Hybrid nanoparticles were synthesized by conjugating monoiodinated cobaltabisdicarbollides (<b>I-COSAN</b>) to commercially available acrylic polymer-based nanoparticles. Functionalization and cellular uptake were confirmed through FTIR, TGA, UV-Vis spectroscopy, and TEM/EDX analyses. Biocompatibility was evaluated by assessing cytotoxicity in HeLa cells and <i>C. elegans</i> as an in vivo model. Intracellular boron uptake was quantified using ICP-MS, with results compared to those obtained with 4-borono-L-phenylalanine conjugated to fructose (<b>f-BPA</b>). An in vitro BNCT proof-of-concept assay was also performed to evaluate therapeutic efficacy. <b>Results</b>: <b>NP@I-COSAN</b> demonstrated low cytotoxicity and efficient internalization in cells. ICP-MS analysis revealed stable boron retention, comparable to traditional boron agents. The BNCT assay further showed that <b>NP@I-COSAN</b> was effective in inducing tumor cell apoptosis, even at lower boron concentrations than conventional treatments. <b>Conclusions</b>: These results underscore the potential of <b>NP@I-COSAN</b> as an effective boron delivery system for BNCT, offering a promising strategy to enhance boron accumulation within tumor cells and improve treatment efficacy. |
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