Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants

To avoid dental implant-related infections and to promote the osseointegration of titanium implants, the application of silicon and chitosan containing coatings is proposed. Silicon is a well-known osteogenic element and chitosan was selected to confer the antibacterial properties. The synthesis of...

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Autores: Palla-Rubio, B., Araújo-Gomes, N., Fernández-Gutiérrez, Mar, Rojo, Luis, Suay, J., Gurruchaga, M., Goñi, Isabel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/173879
Acceso en línea:http://hdl.handle.net/10261/173879
Access Level:acceso abierto
Palabra clave:Dental implant
Silicon
Sol-gel coatings
Chitosan
Antibacterial
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spelling Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implantsPalla-Rubio, B.Araújo-Gomes, N.Fernández-Gutiérrez, MarRojo, LuisSuay, J.Gurruchaga, M.Goñi, IsabelDental implantSiliconSol-gel coatingsChitosanAntibacterialTo avoid dental implant-related infections and to promote the osseointegration of titanium implants, the application of silicon and chitosan containing coatings is proposed. Silicon is a well-known osteogenic element and chitosan was selected to confer the antibacterial properties. The synthesis of hybrid silica-chitosan coatings using the sol-gel process is presented and the characterization using Si-NMR to verify the correct formation of the network is discussed. The C NMR spectroscopy was used to confirm the covalent union between chitosan and the silicon network. Hydrolytic degradation and silicon release studies showed the effective silicon release from the hybrids and, hence, the possibility to promote bone formation. The introduction of different amounts of chitosan and tetraethyl orthosilicate (TEOS) modulated the Si release. The analysis of cell cultures in vitro demonstrated that the hybrid coatings were not cytotoxic and promoted cell proliferation on their surfaces. The coatings containing 5%–10% chitosan had substantial antibacterial properties.This research was supported by the Spanish Ministry of Economy and Competitiveness projectMAT2017-86043-R, the University of the Basque Country (UPV/EHU) project UFI11/56, Basque Government project IT611-13 and a personal grant (predoc-2016-1-0141) and Universitat Jaume I (grant numbers Predoc/2014/25, UJI-B2017-37). The authors thank for technical and personnel support provided by SGIker of UPV/EHU and the European funding sources (ERDF and ESF). We are especially grateful to Antonio Coso and the personnel of his company (Ilerimplant S.L) for their cooperation and to María Rosa Ana Ramírez for her service at the ICTP laboratories.Peer reviewedPeer ReviewedElsevierUniversidad del País VascoEuropean CommissionMinisterio de Economía, Industria y Competitividad (España)Universidad Jaime IConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2019201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/173879reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2017-86043-RSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1738792026-05-22T06:33:51Z
dc.title.none.fl_str_mv Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants
title Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants
spellingShingle Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants
Palla-Rubio, B.
Dental implant
Silicon
Sol-gel coatings
Chitosan
Antibacterial
title_short Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants
title_full Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants
title_fullStr Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants
title_full_unstemmed Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants
title_sort Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants
dc.creator.none.fl_str_mv Palla-Rubio, B.
Araújo-Gomes, N.
Fernández-Gutiérrez, Mar
Rojo, Luis
Suay, J.
Gurruchaga, M.
Goñi, Isabel
author Palla-Rubio, B.
author_facet Palla-Rubio, B.
Araújo-Gomes, N.
Fernández-Gutiérrez, Mar
Rojo, Luis
Suay, J.
Gurruchaga, M.
Goñi, Isabel
author_role author
author2 Araújo-Gomes, N.
Fernández-Gutiérrez, Mar
Rojo, Luis
Suay, J.
Gurruchaga, M.
Goñi, Isabel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad del País Vasco
European Commission
Ministerio de Economía, Industria y Competitividad (España)
Universidad Jaime I
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Dental implant
Silicon
Sol-gel coatings
Chitosan
Antibacterial
topic Dental implant
Silicon
Sol-gel coatings
Chitosan
Antibacterial
description To avoid dental implant-related infections and to promote the osseointegration of titanium implants, the application of silicon and chitosan containing coatings is proposed. Silicon is a well-known osteogenic element and chitosan was selected to confer the antibacterial properties. The synthesis of hybrid silica-chitosan coatings using the sol-gel process is presented and the characterization using Si-NMR to verify the correct formation of the network is discussed. The C NMR spectroscopy was used to confirm the covalent union between chitosan and the silicon network. Hydrolytic degradation and silicon release studies showed the effective silicon release from the hybrids and, hence, the possibility to promote bone formation. The introduction of different amounts of chitosan and tetraethyl orthosilicate (TEOS) modulated the Si release. The analysis of cell cultures in vitro demonstrated that the hybrid coatings were not cytotoxic and promoted cell proliferation on their surfaces. The coatings containing 5%–10% chitosan had substantial antibacterial properties.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/173879
url http://hdl.handle.net/10261/173879
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2017-86043-R
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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