PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Trebicka, Jonel|||0000-0002-7028-3881; Fernández, Javier|||0000-0002-5622-0489; Papp, Maria|||0000-0003-3662-4010; Caraceni, Paolo|||0000-0002-1439-056X; Laleman, Wim|||0000-0002-0842-7813; Gambino, Carmine|||0000-0001-9376-1527; Giovo, Ilaria|||0000-0002-6368-2964; Uschner, Frank Erhard; Jansen, Christian; Jiménez, Cesar|||0000-0003-2455-2048; Mookerjee, Rajeshwar Prosad|||0000-0002-6275-9384; Gustot, Thierry|||0000-0002-5537-9607; Albillos, Agustín|||0000-0001-9131-2592; Bañares, Rafael|||0000-0002-0412-8437; Jarcuska, Peter|||0000-0001-6169-9984; Steib, Christian|||0000-0002-4748-8248; Reiberger, Thomas|||0000-0002-4590-3583; Acevedo, Juan|||0000-0003-4507-2422; Gatti, Pietro|||0000-0003-0368-7509; Shawcross, Debbie|||0000-0001-6133-4619; Zeuzem, Stefan|||0000-0002-0845-6833; Zipprich, Alexander|||0000-0001-8403-7983; Piano, Salvatore|||0000-0002-9356-5830; Berg, Thomas|||0000-0003-0003-6241; Bruns, Tony|||0000-0002-5576-6914; Danielsen, Karen Vagner|||0000-0001-7194-4541; Coenraad, Minneke|||0000-0002-3434-4421; Merli, Manuela|||0000-0003-3173-9767; Stauber, Rudolf|||0000-0002-3687-9331; Zoller, Heinz|||0000-0003-1794-422X; Presa Ramos, José; Solé Martí, Cristina|||0000-0002-6104-8345; Soriano, German|||0000-0002-9267-6811; De Gottardi, Andrea|||0000-0002-4401-2340; Gronbaek, Henning|||0000-0001-8998-7910; Saliba, Faouzi|||0000-0002-2058-9217; Trautwein, Christian; Kani, Haluk Tarik; Francque, Sven|||0000-0002-7527-4714; Ryder, Stephen David|||0000-0001-9649-4444; Nahon, Pierre|||0000-0003-2489-0768; Romero-Gómez, Manuel|||0000-0001-8494-8947; Van Vlierberghe, Hans|||0000-0003-0647-9238; Francoz, Claire|||0000-0001-7391-8507; Manns, Michael|||0000-0002-4485-8856; Garcia-Lopez, Elisabet; Tufoni, Manuel|||0000-0002-8588-193X; Amoros, Alex; Pavesi, Marco; Sanchez, Cristina; Praktiknjo, Michael|||0000-0001-7033-9956; Curto, Anna|||0000-0002-6625-3639; Pitarch, Carla|||0000-0002-6015-244X; Putignano, Antonella|||0000-0002-4083-2405; Moreno, Esau; Bernal, William|||0000-0002-6508-3287; Aguilar Parera, Ferran|||0000-0002-4367-8095; Claria, Joan|||0000-0003-4333-7749; Ponzo, Paola; Vitalis, Zsuzsanna|||0000-0001-8198-5312; Zaccherini, Giacomo|||0000-0002-3219-6963; Balogh, Boglarka|||0000-0002-5670-1063; Gerbes, Alexander L.|||0000-0003-0440-7417; Vargas Blasco, Víctor|||0000-0002-7190-6948; Alessandria, Carlo|||0000-0001-5468-694X; Bernardi, Mauro|||0000-0002-1308-5440; Ginès, Pere|||0000-0003-4657-4504; Moreau, Richard|||0000-0003-0862-403X; Angeli, Paolo|||0000-0002-1913-0716; Jalan, Rajiv; Arroyo, Vicente|||0000-0002-2728-1848; Maschmeier, Miriam; Semela, David; Elkrief, Laure|||0000-0003-2843-1710; Elsharkawy, Ahmed; Tornai, Tamas; Tornai, Istvan; Altorjay, Istvan; Antognoli, Agnese; Baldassarre, Maurizio|||0000-0001-7865-394X; Gagliardi, Martina; Bertoli, Eleonora; Mareso, Sara; Brocca, Alessandra; Campion, Daniela; Saracco, Giorgio Maria|||0000-0001-5310-4143; Rizzo, Martina; Lehmann, Jennifer; Pohlmann, Alessandra; Brol, Maximilian Joseph|||0000-0003-2879-7560; Chang, Johannes; Schierwagen, Robert; Solà, Elsa|||0000-0001-6897-2760; Amari, Nesrine; Rodriguez, Miguel; Nevens, Frederik|||0000-0003-2905-5112; Clemente, Ana; Janicko, Martin|||0000-0002-3329-3968; Markwardt, Daniel; Mandorfer, Mattias|||0000-0003-2330-0017; Welsch, Christoph; Welzel, Tanja M.; Ciraci, Emanuela; Patel, Vish; Ripoll, Cristina; Herber, Adam; Horn, Paul|||0000-0002-8755-7703; Bendtsen, Flemming; Gluud, Lise Lotte|||0000-0002-9462-4468; Schaapman, Jelte; Riggio, Oliviero; Rainer, Florian; Moritz, Jörg Tobiasch; Mesquita, Mónica|||0000-0002-9490-7919; Alvarado-Tapias, Edilmar|||0000-0003-2036-6133; Akpata, Osagie; Aamann, Luise; Samuel, Didier; Tresson, Sylvie; Strnad, Pavel; Amathieu, Roland; Simón Talero, Macarena|||0000-0002-1409-3936; Smits, Francois; van den Ende, Natalie; Martinez González, Javier|||0000-0002-0094-7291; Garcia, Rita; Rupprechter, Harald; Engelmann, Cornelius; Özdogan, Osman Cavit

PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Background & Aims: Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading to both of these AD phenotypes. Methods: Th...

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Authors:	Trebicka, Jonel\|\|\|0000-0002-7028-3881, Fernández, Javier\|\|\|0000-0002-5622-0489, Papp, Maria\|\|\|0000-0003-3662-4010, Caraceni, Paolo\|\|\|0000-0002-1439-056X, Laleman, Wim\|\|\|0000-0002-0842-7813, Gambino, Carmine\|\|\|0000-0001-9376-1527, Giovo, Ilaria\|\|\|0000-0002-6368-2964, Uschner, Frank Erhard, Jansen, Christian, Jiménez, Cesar\|\|\|0000-0003-2455-2048, Mookerjee, Rajeshwar Prosad\|\|\|0000-0002-6275-9384, Gustot, Thierry\|\|\|0000-0002-5537-9607, Albillos, Agustín\|\|\|0000-0001-9131-2592, Bañares, Rafael\|\|\|0000-0002-0412-8437, Jarcuska, Peter\|\|\|0000-0001-6169-9984, Steib, Christian\|\|\|0000-0002-4748-8248, Reiberger, Thomas\|\|\|0000-0002-4590-3583, Acevedo, Juan\|\|\|0000-0003-4507-2422, Gatti, Pietro\|\|\|0000-0003-0368-7509, Shawcross, Debbie\|\|\|0000-0001-6133-4619, Zeuzem, Stefan\|\|\|0000-0002-0845-6833, Zipprich, Alexander\|\|\|0000-0001-8403-7983, Piano, Salvatore\|\|\|0000-0002-9356-5830, Berg, Thomas\|\|\|0000-0003-0003-6241, Bruns, Tony\|\|\|0000-0002-5576-6914, Danielsen, Karen Vagner\|\|\|0000-0001-7194-4541, Coenraad, Minneke\|\|\|0000-0002-3434-4421, Merli, Manuela\|\|\|0000-0003-3173-9767, Stauber, Rudolf\|\|\|0000-0002-3687-9331, Zoller, Heinz\|\|\|0000-0003-1794-422X, Presa Ramos, José, Solé Martí, Cristina\|\|\|0000-0002-6104-8345, Soriano, German\|\|\|0000-0002-9267-6811, De Gottardi, Andrea\|\|\|0000-0002-4401-2340, Gronbaek, Henning\|\|\|0000-0001-8998-7910, Saliba, Faouzi\|\|\|0000-0002-2058-9217, Trautwein, Christian, Kani, Haluk Tarik, Francque, Sven\|\|\|0000-0002-7527-4714, Ryder, Stephen David\|\|\|0000-0001-9649-4444, Nahon, Pierre\|\|\|0000-0003-2489-0768, Romero-Gómez, Manuel\|\|\|0000-0001-8494-8947, Van Vlierberghe, Hans\|\|\|0000-0003-0647-9238, Francoz, Claire\|\|\|0000-0001-7391-8507, Manns, Michael\|\|\|0000-0002-4485-8856, Garcia-Lopez, Elisabet, Tufoni, Manuel\|\|\|0000-0002-8588-193X, Amoros, Alex, Pavesi, Marco, Sanchez, Cristina, Praktiknjo, Michael\|\|\|0000-0001-7033-9956, Curto, Anna\|\|\|0000-0002-6625-3639, Pitarch, Carla\|\|\|0000-0002-6015-244X, Putignano, Antonella\|\|\|0000-0002-4083-2405, Moreno, Esau, Bernal, William\|\|\|0000-0002-6508-3287, Aguilar Parera, Ferran\|\|\|0000-0002-4367-8095, Claria, Joan\|\|\|0000-0003-4333-7749, Ponzo, Paola, Vitalis, Zsuzsanna\|\|\|0000-0001-8198-5312, Zaccherini, Giacomo\|\|\|0000-0002-3219-6963, Balogh, Boglarka\|\|\|0000-0002-5670-1063, Gerbes, Alexander L.\|\|\|0000-0003-0440-7417, Vargas Blasco, Víctor\|\|\|0000-0002-7190-6948, Alessandria, Carlo\|\|\|0000-0001-5468-694X, Bernardi, Mauro\|\|\|0000-0002-1308-5440, Ginès, Pere\|\|\|0000-0003-4657-4504, Moreau, Richard\|\|\|0000-0003-0862-403X, Angeli, Paolo\|\|\|0000-0002-1913-0716, Jalan, Rajiv, Arroyo, Vicente\|\|\|0000-0002-2728-1848, Maschmeier, Miriam, Semela, David, Elkrief, Laure\|\|\|0000-0003-2843-1710, Elsharkawy, Ahmed, Tornai, Tamas, Tornai, Istvan, Altorjay, Istvan, Antognoli, Agnese, Baldassarre, Maurizio\|\|\|0000-0001-7865-394X, Gagliardi, Martina, Bertoli, Eleonora, Mareso, Sara, Brocca, Alessandra, Campion, Daniela, Saracco, Giorgio Maria\|\|\|0000-0001-5310-4143, Rizzo, Martina, Lehmann, Jennifer, Pohlmann, Alessandra, Brol, Maximilian Joseph\|\|\|0000-0003-2879-7560, Chang, Johannes, Schierwagen, Robert, Solà, Elsa\|\|\|0000-0001-6897-2760, Amari, Nesrine, Rodriguez, Miguel, Nevens, Frederik\|\|\|0000-0003-2905-5112, Clemente, Ana, Janicko, Martin\|\|\|0000-0002-3329-3968, Markwardt, Daniel, Mandorfer, Mattias\|\|\|0000-0003-2330-0017, Welsch, Christoph, Welzel, Tanja M., Ciraci, Emanuela, Patel, Vish, Ripoll, Cristina, Herber, Adam, Horn, Paul\|\|\|0000-0002-8755-7703, Bendtsen, Flemming, Gluud, Lise Lotte\|\|\|0000-0002-9462-4468, Schaapman, Jelte, Riggio, Oliviero, Rainer, Florian, Moritz, Jörg Tobiasch, Mesquita, Mónica\|\|\|0000-0002-9490-7919, Alvarado-Tapias, Edilmar\|\|\|0000-0003-2036-6133, Akpata, Osagie, Aamann, Luise, Samuel, Didier, Tresson, Sylvie, Strnad, Pavel, Amathieu, Roland, Simón Talero, Macarena\|\|\|0000-0002-1409-3936, Smits, Francois, van den Ende, Natalie, Martinez González, Javier\|\|\|0000-0002-0094-7291, Garcia, Rita, Rupprechter, Harald, Engelmann, Cornelius, Özdogan, Osman Cavit
Format:	article
Publication Date:	2021
Country:	España
Institution:	Universitat Autònoma de Barcelona
Repository:	Dipòsit Digital de Documents de la UAB
Language:	English
OAI Identifier:	oai:ddd.uab.cat:272001
Online Access:	https://ddd.uab.cat/record/272001 https://dx.doi.org/urn:doi:10.1016/j.jhep.2020.11.019
Access Level:	Open access
Keyword:	Chronic liver disease Non-elective admission Acute complications Outcome Risk factors

id	ES_5400aacef42a52448dda028fa7af004a
oai_identifier_str	oai:ddd.uab.cat:272001
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
title	PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
spellingShingle	PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis Trebicka, Jonel\|\|\|0000-0002-7028-3881 Chronic liver disease Non-elective admission Acute complications Outcome Risk factors
title_short	PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
title_full	PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
title_fullStr	PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
title_full_unstemmed	PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
title_sort	PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
dc.creator.none.fl_str_mv	Trebicka, Jonel\|\|\|0000-0002-7028-3881 Fernández, Javier\|\|\|0000-0002-5622-0489 Papp, Maria\|\|\|0000-0003-3662-4010 Caraceni, Paolo\|\|\|0000-0002-1439-056X Laleman, Wim\|\|\|0000-0002-0842-7813 Gambino, Carmine\|\|\|0000-0001-9376-1527 Giovo, Ilaria\|\|\|0000-0002-6368-2964 Uschner, Frank Erhard Jansen, Christian Jiménez, Cesar\|\|\|0000-0003-2455-2048 Mookerjee, Rajeshwar Prosad\|\|\|0000-0002-6275-9384 Gustot, Thierry\|\|\|0000-0002-5537-9607 Albillos, Agustín\|\|\|0000-0001-9131-2592 Bañares, Rafael\|\|\|0000-0002-0412-8437 Jarcuska, Peter\|\|\|0000-0001-6169-9984 Steib, Christian\|\|\|0000-0002-4748-8248 Reiberger, Thomas\|\|\|0000-0002-4590-3583 Acevedo, Juan\|\|\|0000-0003-4507-2422 Gatti, Pietro\|\|\|0000-0003-0368-7509 Shawcross, Debbie\|\|\|0000-0001-6133-4619 Zeuzem, Stefan\|\|\|0000-0002-0845-6833 Zipprich, Alexander\|\|\|0000-0001-8403-7983 Piano, Salvatore\|\|\|0000-0002-9356-5830 Berg, Thomas\|\|\|0000-0003-0003-6241 Bruns, Tony\|\|\|0000-0002-5576-6914 Danielsen, Karen Vagner\|\|\|0000-0001-7194-4541 Coenraad, Minneke\|\|\|0000-0002-3434-4421 Merli, Manuela\|\|\|0000-0003-3173-9767 Stauber, Rudolf\|\|\|0000-0002-3687-9331 Zoller, Heinz\|\|\|0000-0003-1794-422X Presa Ramos, José Solé Martí, Cristina\|\|\|0000-0002-6104-8345 Soriano, German\|\|\|0000-0002-9267-6811 De Gottardi, Andrea\|\|\|0000-0002-4401-2340 Gronbaek, Henning\|\|\|0000-0001-8998-7910 Saliba, Faouzi\|\|\|0000-0002-2058-9217 Trautwein, Christian Kani, Haluk Tarik Francque, Sven\|\|\|0000-0002-7527-4714 Ryder, Stephen David\|\|\|0000-0001-9649-4444 Nahon, Pierre\|\|\|0000-0003-2489-0768 Romero-Gómez, Manuel\|\|\|0000-0001-8494-8947 Van Vlierberghe, Hans\|\|\|0000-0003-0647-9238 Francoz, Claire\|\|\|0000-0001-7391-8507 Manns, Michael\|\|\|0000-0002-4485-8856 Garcia-Lopez, Elisabet Tufoni, Manuel\|\|\|0000-0002-8588-193X Amoros, Alex Pavesi, Marco Sanchez, Cristina Praktiknjo, Michael\|\|\|0000-0001-7033-9956 Curto, Anna\|\|\|0000-0002-6625-3639 Pitarch, Carla\|\|\|0000-0002-6015-244X Putignano, Antonella\|\|\|0000-0002-4083-2405 Moreno, Esau Bernal, William\|\|\|0000-0002-6508-3287 Aguilar Parera, Ferran\|\|\|0000-0002-4367-8095 Claria, Joan\|\|\|0000-0003-4333-7749 Ponzo, Paola Vitalis, Zsuzsanna\|\|\|0000-0001-8198-5312 Zaccherini, Giacomo\|\|\|0000-0002-3219-6963 Balogh, Boglarka\|\|\|0000-0002-5670-1063 Gerbes, Alexander L.\|\|\|0000-0003-0440-7417 Vargas Blasco, Víctor\|\|\|0000-0002-7190-6948 Alessandria, Carlo\|\|\|0000-0001-5468-694X Bernardi, Mauro\|\|\|0000-0002-1308-5440 Ginès, Pere\|\|\|0000-0003-4657-4504 Moreau, Richard\|\|\|0000-0003-0862-403X Angeli, Paolo\|\|\|0000-0002-1913-0716 Jalan, Rajiv Arroyo, Vicente\|\|\|0000-0002-2728-1848 Maschmeier, Miriam Semela, David Elkrief, Laure\|\|\|0000-0003-2843-1710 Elsharkawy, Ahmed Tornai, Tamas Tornai, Istvan Altorjay, Istvan Antognoli, Agnese Baldassarre, Maurizio\|\|\|0000-0001-7865-394X Gagliardi, Martina Bertoli, Eleonora Mareso, Sara Brocca, Alessandra Campion, Daniela Saracco, Giorgio Maria\|\|\|0000-0001-5310-4143 Rizzo, Martina Lehmann, Jennifer Pohlmann, Alessandra Brol, Maximilian Joseph\|\|\|0000-0003-2879-7560 Chang, Johannes Schierwagen, Robert Solà, Elsa\|\|\|0000-0001-6897-2760 Amari, Nesrine Rodriguez, Miguel Nevens, Frederik\|\|\|0000-0003-2905-5112 Clemente, Ana Janicko, Martin\|\|\|0000-0002-3329-3968 Markwardt, Daniel Mandorfer, Mattias\|\|\|0000-0003-2330-0017 Welsch, Christoph Welzel, Tanja M. Ciraci, Emanuela Patel, Vish Ripoll, Cristina Herber, Adam Horn, Paul\|\|\|0000-0002-8755-7703 Bendtsen, Flemming Gluud, Lise Lotte\|\|\|0000-0002-9462-4468 Schaapman, Jelte Riggio, Oliviero Rainer, Florian Moritz, Jörg Tobiasch Mesquita, Mónica\|\|\|0000-0002-9490-7919 Alvarado-Tapias, Edilmar\|\|\|0000-0003-2036-6133 Akpata, Osagie Aamann, Luise Samuel, Didier Tresson, Sylvie Strnad, Pavel Amathieu, Roland Simón Talero, Macarena\|\|\|0000-0002-1409-3936 Smits, Francois van den Ende, Natalie Martinez González, Javier\|\|\|0000-0002-0094-7291 Garcia, Rita Rupprechter, Harald Engelmann, Cornelius Özdogan, Osman Cavit
author	Trebicka, Jonel\|\|\|0000-0002-7028-3881
author_facet	Trebicka, Jonel\|\|\|0000-0002-7028-3881 Fernández, Javier\|\|\|0000-0002-5622-0489 Papp, Maria\|\|\|0000-0003-3662-4010 Caraceni, Paolo\|\|\|0000-0002-1439-056X Laleman, Wim\|\|\|0000-0002-0842-7813 Gambino, Carmine\|\|\|0000-0001-9376-1527 Giovo, Ilaria\|\|\|0000-0002-6368-2964 Uschner, Frank Erhard Jansen, Christian Jiménez, Cesar\|\|\|0000-0003-2455-2048 Mookerjee, Rajeshwar Prosad\|\|\|0000-0002-6275-9384 Gustot, Thierry\|\|\|0000-0002-5537-9607 Albillos, Agustín\|\|\|0000-0001-9131-2592 Bañares, Rafael\|\|\|0000-0002-0412-8437 Jarcuska, Peter\|\|\|0000-0001-6169-9984 Steib, Christian\|\|\|0000-0002-4748-8248 Reiberger, Thomas\|\|\|0000-0002-4590-3583 Acevedo, Juan\|\|\|0000-0003-4507-2422 Gatti, Pietro\|\|\|0000-0003-0368-7509 Shawcross, Debbie\|\|\|0000-0001-6133-4619 Zeuzem, Stefan\|\|\|0000-0002-0845-6833 Zipprich, Alexander\|\|\|0000-0001-8403-7983 Piano, Salvatore\|\|\|0000-0002-9356-5830 Berg, Thomas\|\|\|0000-0003-0003-6241 Bruns, Tony\|\|\|0000-0002-5576-6914 Danielsen, Karen Vagner\|\|\|0000-0001-7194-4541 Coenraad, Minneke\|\|\|0000-0002-3434-4421 Merli, Manuela\|\|\|0000-0003-3173-9767 Stauber, Rudolf\|\|\|0000-0002-3687-9331 Zoller, Heinz\|\|\|0000-0003-1794-422X Presa Ramos, José Solé Martí, Cristina\|\|\|0000-0002-6104-8345 Soriano, German\|\|\|0000-0002-9267-6811 De Gottardi, Andrea\|\|\|0000-0002-4401-2340 Gronbaek, Henning\|\|\|0000-0001-8998-7910 Saliba, Faouzi\|\|\|0000-0002-2058-9217 Trautwein, Christian Kani, Haluk Tarik Francque, Sven\|\|\|0000-0002-7527-4714 Ryder, Stephen David\|\|\|0000-0001-9649-4444 Nahon, Pierre\|\|\|0000-0003-2489-0768 Romero-Gómez, Manuel\|\|\|0000-0001-8494-8947 Van Vlierberghe, Hans\|\|\|0000-0003-0647-9238 Francoz, Claire\|\|\|0000-0001-7391-8507 Manns, Michael\|\|\|0000-0002-4485-8856 Garcia-Lopez, Elisabet Tufoni, Manuel\|\|\|0000-0002-8588-193X Amoros, Alex Pavesi, Marco Sanchez, Cristina Praktiknjo, Michael\|\|\|0000-0001-7033-9956 Curto, Anna\|\|\|0000-0002-6625-3639 Pitarch, Carla\|\|\|0000-0002-6015-244X Putignano, Antonella\|\|\|0000-0002-4083-2405 Moreno, Esau Bernal, William\|\|\|0000-0002-6508-3287 Aguilar Parera, Ferran\|\|\|0000-0002-4367-8095 Claria, Joan\|\|\|0000-0003-4333-7749 Ponzo, Paola Vitalis, Zsuzsanna\|\|\|0000-0001-8198-5312 Zaccherini, Giacomo\|\|\|0000-0002-3219-6963 Balogh, Boglarka\|\|\|0000-0002-5670-1063 Gerbes, Alexander L.\|\|\|0000-0003-0440-7417 Vargas Blasco, Víctor\|\|\|0000-0002-7190-6948 Alessandria, Carlo\|\|\|0000-0001-5468-694X Bernardi, Mauro\|\|\|0000-0002-1308-5440 Ginès, Pere\|\|\|0000-0003-4657-4504 Moreau, Richard\|\|\|0000-0003-0862-403X Angeli, Paolo\|\|\|0000-0002-1913-0716 Jalan, Rajiv Arroyo, Vicente\|\|\|0000-0002-2728-1848 Maschmeier, Miriam Semela, David Elkrief, Laure\|\|\|0000-0003-2843-1710 Elsharkawy, Ahmed Tornai, Tamas Tornai, Istvan Altorjay, Istvan Antognoli, Agnese Baldassarre, Maurizio\|\|\|0000-0001-7865-394X Gagliardi, Martina Bertoli, Eleonora Mareso, Sara Brocca, Alessandra Campion, Daniela Saracco, Giorgio Maria\|\|\|0000-0001-5310-4143 Rizzo, Martina Lehmann, Jennifer Pohlmann, Alessandra Brol, Maximilian Joseph\|\|\|0000-0003-2879-7560 Chang, Johannes Schierwagen, Robert Solà, Elsa\|\|\|0000-0001-6897-2760 Amari, Nesrine Rodriguez, Miguel Nevens, Frederik\|\|\|0000-0003-2905-5112 Clemente, Ana Janicko, Martin\|\|\|0000-0002-3329-3968 Markwardt, Daniel Mandorfer, Mattias\|\|\|0000-0003-2330-0017 Welsch, Christoph Welzel, Tanja M. Ciraci, Emanuela Patel, Vish Ripoll, Cristina Herber, Adam Horn, Paul\|\|\|0000-0002-8755-7703 Bendtsen, Flemming Gluud, Lise Lotte\|\|\|0000-0002-9462-4468 Schaapman, Jelte Riggio, Oliviero Rainer, Florian Moritz, Jörg Tobiasch Mesquita, Mónica\|\|\|0000-0002-9490-7919 Alvarado-Tapias, Edilmar\|\|\|0000-0003-2036-6133 Akpata, Osagie Aamann, Luise Samuel, Didier Tresson, Sylvie Strnad, Pavel Amathieu, Roland Simón Talero, Macarena\|\|\|0000-0002-1409-3936 Smits, Francois van den Ende, Natalie Martinez González, Javier\|\|\|0000-0002-0094-7291 Garcia, Rita Rupprechter, Harald Engelmann, Cornelius Özdogan, Osman Cavit
author_role	author
author2	Fernández, Javier\|\|\|0000-0002-5622-0489 Papp, Maria\|\|\|0000-0003-3662-4010 Caraceni, Paolo\|\|\|0000-0002-1439-056X Laleman, Wim\|\|\|0000-0002-0842-7813 Gambino, Carmine\|\|\|0000-0001-9376-1527 Giovo, Ilaria\|\|\|0000-0002-6368-2964 Uschner, Frank Erhard Jansen, Christian Jiménez, Cesar\|\|\|0000-0003-2455-2048 Mookerjee, Rajeshwar Prosad\|\|\|0000-0002-6275-9384 Gustot, Thierry\|\|\|0000-0002-5537-9607 Albillos, Agustín\|\|\|0000-0001-9131-2592 Bañares, Rafael\|\|\|0000-0002-0412-8437 Jarcuska, Peter\|\|\|0000-0001-6169-9984 Steib, Christian\|\|\|0000-0002-4748-8248 Reiberger, Thomas\|\|\|0000-0002-4590-3583 Acevedo, Juan\|\|\|0000-0003-4507-2422 Gatti, Pietro\|\|\|0000-0003-0368-7509 Shawcross, Debbie\|\|\|0000-0001-6133-4619 Zeuzem, Stefan\|\|\|0000-0002-0845-6833 Zipprich, Alexander\|\|\|0000-0001-8403-7983 Piano, Salvatore\|\|\|0000-0002-9356-5830 Berg, Thomas\|\|\|0000-0003-0003-6241 Bruns, Tony\|\|\|0000-0002-5576-6914 Danielsen, Karen Vagner\|\|\|0000-0001-7194-4541 Coenraad, Minneke\|\|\|0000-0002-3434-4421 Merli, Manuela\|\|\|0000-0003-3173-9767 Stauber, Rudolf\|\|\|0000-0002-3687-9331 Zoller, Heinz\|\|\|0000-0003-1794-422X Presa Ramos, José Solé Martí, Cristina\|\|\|0000-0002-6104-8345 Soriano, German\|\|\|0000-0002-9267-6811 De Gottardi, Andrea\|\|\|0000-0002-4401-2340 Gronbaek, Henning\|\|\|0000-0001-8998-7910 Saliba, Faouzi\|\|\|0000-0002-2058-9217 Trautwein, Christian Kani, Haluk Tarik Francque, Sven\|\|\|0000-0002-7527-4714 Ryder, Stephen David\|\|\|0000-0001-9649-4444 Nahon, Pierre\|\|\|0000-0003-2489-0768 Romero-Gómez, Manuel\|\|\|0000-0001-8494-8947 Van Vlierberghe, Hans\|\|\|0000-0003-0647-9238 Francoz, Claire\|\|\|0000-0001-7391-8507 Manns, Michael\|\|\|0000-0002-4485-8856 Garcia-Lopez, Elisabet Tufoni, Manuel\|\|\|0000-0002-8588-193X Amoros, Alex Pavesi, Marco Sanchez, Cristina Praktiknjo, Michael\|\|\|0000-0001-7033-9956 Curto, Anna\|\|\|0000-0002-6625-3639 Pitarch, Carla\|\|\|0000-0002-6015-244X Putignano, Antonella\|\|\|0000-0002-4083-2405 Moreno, Esau Bernal, William\|\|\|0000-0002-6508-3287 Aguilar Parera, Ferran\|\|\|0000-0002-4367-8095 Claria, Joan\|\|\|0000-0003-4333-7749 Ponzo, Paola Vitalis, Zsuzsanna\|\|\|0000-0001-8198-5312 Zaccherini, Giacomo\|\|\|0000-0002-3219-6963 Balogh, Boglarka\|\|\|0000-0002-5670-1063 Gerbes, Alexander L.\|\|\|0000-0003-0440-7417 Vargas Blasco, Víctor\|\|\|0000-0002-7190-6948 Alessandria, Carlo\|\|\|0000-0001-5468-694X Bernardi, Mauro\|\|\|0000-0002-1308-5440 Ginès, Pere\|\|\|0000-0003-4657-4504 Moreau, Richard\|\|\|0000-0003-0862-403X Angeli, Paolo\|\|\|0000-0002-1913-0716 Jalan, Rajiv Arroyo, Vicente\|\|\|0000-0002-2728-1848 Maschmeier, Miriam Semela, David Elkrief, Laure\|\|\|0000-0003-2843-1710 Elsharkawy, Ahmed Tornai, Tamas Tornai, Istvan Altorjay, Istvan Antognoli, Agnese Baldassarre, Maurizio\|\|\|0000-0001-7865-394X Gagliardi, Martina Bertoli, Eleonora Mareso, Sara Brocca, Alessandra Campion, Daniela Saracco, Giorgio Maria\|\|\|0000-0001-5310-4143 Rizzo, Martina Lehmann, Jennifer Pohlmann, Alessandra Brol, Maximilian Joseph\|\|\|0000-0003-2879-7560 Chang, Johannes Schierwagen, Robert Solà, Elsa\|\|\|0000-0001-6897-2760 Amari, Nesrine Rodriguez, Miguel Nevens, Frederik\|\|\|0000-0003-2905-5112 Clemente, Ana Janicko, Martin\|\|\|0000-0002-3329-3968 Markwardt, Daniel Mandorfer, Mattias\|\|\|0000-0003-2330-0017 Welsch, Christoph Welzel, Tanja M. Ciraci, Emanuela Patel, Vish Ripoll, Cristina Herber, Adam Horn, Paul\|\|\|0000-0002-8755-7703 Bendtsen, Flemming Gluud, Lise Lotte\|\|\|0000-0002-9462-4468 Schaapman, Jelte Riggio, Oliviero Rainer, Florian Moritz, Jörg Tobiasch Mesquita, Mónica\|\|\|0000-0002-9490-7919 Alvarado-Tapias, Edilmar\|\|\|0000-0003-2036-6133 Akpata, Osagie Aamann, Luise Samuel, Didier Tresson, Sylvie Strnad, Pavel Amathieu, Roland Simón Talero, Macarena\|\|\|0000-0002-1409-3936 Smits, Francois van den Ende, Natalie Martinez González, Javier\|\|\|0000-0002-0094-7291 Garcia, Rita Rupprechter, Harald Engelmann, Cornelius Özdogan, Osman Cavit
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv	Chronic liver disease Non-elective admission Acute complications Outcome Risk factors
topic	Chronic liver disease Non-elective admission Acute complications Outcome Risk factors
description	Background & Aims: Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading to both of these AD phenotypes. Methods: The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients with AD (No ACLF = 1,071; ACLF = 202). Medical history, clinical data and laboratory data were collected at enrolment and during 90-day follow-up, with particular attention given to the following characteristics of precipitants: induction of organ dysfunction or failure, systemic inflammation, chronology, intensity, and relationship to outcome. Results: Among various clinical events, 4 distinct events were precipitants consistently related to AD: proven bacterial infections, severe alcoholic hepatitis, gastrointestinal bleeding with shock and toxic encephalopathy. Among patients with precipitants in the AD-No ACLF cohort and the AD-ACLF cohort (38% and 71%, respectively), almost all (96% and 97%, respectively) showed proven bacterial infection and severe alcoholic hepatitis, either alone or in combination with other events. Survival was similar in patients with proven bacterial infections or severe alcoholic hepatitis in both AD phenotypes. The number of precipitants was associated with significantly increased 90-day mortality and was paralleled by increasing levels of surrogates for systemic inflammation. Importantly, adequate first-line antibiotic treatment of proven bacterial infections was associated with a lower ACLF development rate and lower 90-day mortality. Conclusions: This study identified precipitants that are significantly associated with a distinct clinical course and prognosis in patients with AD. Specific preventive and therapeutic strategies targeting these events may improve outcomes in patients with decompensated cirrhosis. Lay summary: Acute decompensation (AD) of cirrhosis is characterized by a rapid deterioration in patient health. Herein, we aimed to analyze the precipitating events that cause AD in patients with cirrhosis. Proven bacterial infections and severe alcoholic hepatitis, either alone or in combination, accounted for almost all (96-97%) cases of AD and acute-on-chronic liver failure. Whilst the type of precipitant was not associated with mortality, the number of precipitant(s) was. This study identified precipitants that are significantly associated with a distinct clinical course and prognosis of patients with AD. Specific preventive and therapeutic strategies targeting these events may improve patient outcomes.
publishDate	2021
dc.date.none.fl_str_mv	2 2021-01-01 2021 2021-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/272001 https://dx.doi.org/urn:doi:10.1016/j.jhep.2020.11.019
url	https://ddd.uab.cat/record/272001 https://dx.doi.org/urn:doi:10.1016/j.jhep.2020.11.019
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling	PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosisTrebicka, Jonel\|\|\|0000-0002-7028-3881Fernández, Javier\|\|\|0000-0002-5622-0489Papp, Maria\|\|\|0000-0003-3662-4010Caraceni, Paolo\|\|\|0000-0002-1439-056XLaleman, Wim\|\|\|0000-0002-0842-7813Gambino, Carmine\|\|\|0000-0001-9376-1527Giovo, Ilaria\|\|\|0000-0002-6368-2964Uschner, Frank ErhardJansen, ChristianJiménez, Cesar\|\|\|0000-0003-2455-2048Mookerjee, Rajeshwar Prosad\|\|\|0000-0002-6275-9384Gustot, Thierry\|\|\|0000-0002-5537-9607Albillos, Agustín\|\|\|0000-0001-9131-2592Bañares, Rafael\|\|\|0000-0002-0412-8437Jarcuska, Peter\|\|\|0000-0001-6169-9984Steib, Christian\|\|\|0000-0002-4748-8248Reiberger, Thomas\|\|\|0000-0002-4590-3583Acevedo, Juan\|\|\|0000-0003-4507-2422Gatti, Pietro\|\|\|0000-0003-0368-7509Shawcross, Debbie\|\|\|0000-0001-6133-4619Zeuzem, Stefan\|\|\|0000-0002-0845-6833Zipprich, Alexander\|\|\|0000-0001-8403-7983Piano, Salvatore\|\|\|0000-0002-9356-5830Berg, Thomas\|\|\|0000-0003-0003-6241Bruns, Tony\|\|\|0000-0002-5576-6914Danielsen, Karen Vagner\|\|\|0000-0001-7194-4541Coenraad, Minneke\|\|\|0000-0002-3434-4421Merli, Manuela\|\|\|0000-0003-3173-9767Stauber, Rudolf\|\|\|0000-0002-3687-9331Zoller, Heinz\|\|\|0000-0003-1794-422XPresa Ramos, JoséSolé Martí, Cristina\|\|\|0000-0002-6104-8345Soriano, German\|\|\|0000-0002-9267-6811De Gottardi, Andrea\|\|\|0000-0002-4401-2340Gronbaek, Henning\|\|\|0000-0001-8998-7910Saliba, Faouzi\|\|\|0000-0002-2058-9217Trautwein, ChristianKani, Haluk TarikFrancque, Sven\|\|\|0000-0002-7527-4714Ryder, Stephen David\|\|\|0000-0001-9649-4444Nahon, Pierre\|\|\|0000-0003-2489-0768Romero-Gómez, Manuel\|\|\|0000-0001-8494-8947Van Vlierberghe, Hans\|\|\|0000-0003-0647-9238Francoz, Claire\|\|\|0000-0001-7391-8507Manns, Michael\|\|\|0000-0002-4485-8856Garcia-Lopez, ElisabetTufoni, Manuel\|\|\|0000-0002-8588-193XAmoros, AlexPavesi, MarcoSanchez, CristinaPraktiknjo, Michael\|\|\|0000-0001-7033-9956Curto, Anna\|\|\|0000-0002-6625-3639Pitarch, Carla\|\|\|0000-0002-6015-244XPutignano, Antonella\|\|\|0000-0002-4083-2405Moreno, EsauBernal, William\|\|\|0000-0002-6508-3287Aguilar Parera, Ferran\|\|\|0000-0002-4367-8095Claria, Joan\|\|\|0000-0003-4333-7749Ponzo, PaolaVitalis, Zsuzsanna\|\|\|0000-0001-8198-5312Zaccherini, Giacomo\|\|\|0000-0002-3219-6963Balogh, Boglarka\|\|\|0000-0002-5670-1063Gerbes, Alexander L.\|\|\|0000-0003-0440-7417Vargas Blasco, Víctor\|\|\|0000-0002-7190-6948Alessandria, Carlo\|\|\|0000-0001-5468-694XBernardi, Mauro\|\|\|0000-0002-1308-5440Ginès, Pere\|\|\|0000-0003-4657-4504Moreau, Richard\|\|\|0000-0003-0862-403XAngeli, Paolo\|\|\|0000-0002-1913-0716Jalan, RajivArroyo, Vicente\|\|\|0000-0002-2728-1848Maschmeier, MiriamSemela, DavidElkrief, Laure\|\|\|0000-0003-2843-1710Elsharkawy, AhmedTornai, TamasTornai, IstvanAltorjay, IstvanAntognoli, AgneseBaldassarre, Maurizio\|\|\|0000-0001-7865-394XGagliardi, MartinaBertoli, EleonoraMareso, SaraBrocca, AlessandraCampion, DanielaSaracco, Giorgio Maria\|\|\|0000-0001-5310-4143Rizzo, MartinaLehmann, JenniferPohlmann, AlessandraBrol, Maximilian Joseph\|\|\|0000-0003-2879-7560Chang, JohannesSchierwagen, RobertSolà, Elsa\|\|\|0000-0001-6897-2760Amari, NesrineRodriguez, MiguelNevens, Frederik\|\|\|0000-0003-2905-5112Clemente, AnaJanicko, Martin\|\|\|0000-0002-3329-3968Markwardt, DanielMandorfer, Mattias\|\|\|0000-0003-2330-0017Welsch, ChristophWelzel, Tanja M.Ciraci, EmanuelaPatel, VishRipoll, CristinaHerber, AdamHorn, Paul\|\|\|0000-0002-8755-7703Bendtsen, FlemmingGluud, Lise Lotte\|\|\|0000-0002-9462-4468Schaapman, JelteRiggio, OlivieroRainer, FlorianMoritz, Jörg TobiaschMesquita, Mónica\|\|\|0000-0002-9490-7919Alvarado-Tapias, Edilmar\|\|\|0000-0003-2036-6133Akpata, OsagieAamann, LuiseSamuel, DidierTresson, SylvieStrnad, PavelAmathieu, RolandSimón Talero, Macarena\|\|\|0000-0002-1409-3936Smits, Francoisvan den Ende, NatalieMartinez González, Javier\|\|\|0000-0002-0094-7291Garcia, RitaRupprechter, HaraldEngelmann, CorneliusÖzdogan, Osman CavitChronic liver diseaseNon-elective admissionAcute complicationsOutcomeRisk factorsBackground & Aims: Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading to both of these AD phenotypes. Methods: The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients with AD (No ACLF = 1,071; ACLF = 202). Medical history, clinical data and laboratory data were collected at enrolment and during 90-day follow-up, with particular attention given to the following characteristics of precipitants: induction of organ dysfunction or failure, systemic inflammation, chronology, intensity, and relationship to outcome. Results: Among various clinical events, 4 distinct events were precipitants consistently related to AD: proven bacterial infections, severe alcoholic hepatitis, gastrointestinal bleeding with shock and toxic encephalopathy. Among patients with precipitants in the AD-No ACLF cohort and the AD-ACLF cohort (38% and 71%, respectively), almost all (96% and 97%, respectively) showed proven bacterial infection and severe alcoholic hepatitis, either alone or in combination with other events. Survival was similar in patients with proven bacterial infections or severe alcoholic hepatitis in both AD phenotypes. The number of precipitants was associated with significantly increased 90-day mortality and was paralleled by increasing levels of surrogates for systemic inflammation. Importantly, adequate first-line antibiotic treatment of proven bacterial infections was associated with a lower ACLF development rate and lower 90-day mortality. Conclusions: This study identified precipitants that are significantly associated with a distinct clinical course and prognosis in patients with AD. Specific preventive and therapeutic strategies targeting these events may improve outcomes in patients with decompensated cirrhosis. Lay summary: Acute decompensation (AD) of cirrhosis is characterized by a rapid deterioration in patient health. Herein, we aimed to analyze the precipitating events that cause AD in patients with cirrhosis. Proven bacterial infections and severe alcoholic hepatitis, either alone or in combination, accounted for almost all (96-97%) cases of AD and acute-on-chronic liver failure. Whilst the type of precipitant was not associated with mortality, the number of precipitant(s) was. This study identified precipitants that are significantly associated with a distinct clinical course and prognosis of patients with AD. Specific preventive and therapeutic strategies targeting these events may improve patient outcomes.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/272001https://dx.doi.org/urn:doi:10.1016/j.jhep.2020.11.019reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2720012026-06-06T12:50:31Z
score	15,300724

PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

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