Comparison of Migration Disturbance Potency of Epigallocatechin Gallate (EGCG) Synthetic Analogs and EGCG PEGylated PLGA Nanoparticles in Rat Neurospheres
Epigallocatechin gallate (EGCG), the main catechin of green tea, is described to have potential health benefits in several fields like oncology, neurology or cardiology. Currently, it is also under pre-clinical investigation as a potential therapeutic or preventive treatment during pregnancy against...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/167697 |
| Acceso en línea: | https://hdl.handle.net/2445/167697 |
| Access Level: | acceso abierto |
| Palabra clave: | Suplements nutritius Neurotoxicologia Embriologia Dietary supplements Neurotoxicology Embryology |
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Comparison of Migration Disturbance Potency of Epigallocatechin Gallate (EGCG) Synthetic Analogs and EGCG PEGylated PLGA Nanoparticles in Rat NeurospheresKühne, Britta A.Puig i Miquel, TeresaRuiz-Martínez, SantiagoCrous-Masó, JoanPlanas, MartaFeliu, LidiaCano Fernández, AmandaGarcía, Maria LuisaFritsche, EllenLlobet Mallafré, Joan M. (Joan Maria)Gómez Catalán, JesúsBarenys Espadaler, MartaSuplements nutritiusNeurotoxicologiaEmbriologiaDietary supplementsNeurotoxicologyEmbryologyEpigallocatechin gallate (EGCG), the main catechin of green tea, is described to have potential health benefits in several fields like oncology, neurology or cardiology. Currently, it is also under pre-clinical investigation as a potential therapeutic or preventive treatment during pregnancy against developmental adverse effects induced by toxic substances. However, the safety of EGCG during pregnancy is unclear due to its proven adverse effects on neural progenitor cells' (NPCs) migration. As lately several strategies have arisen to generate new therapeutic agents derived from EGCG, we have used the rat 'Neurosphere Assay' to characterize and compare the effects of EGCG structurally related compounds and EGCG PEGylated PLGA nanoparticles on a neurodevelopmental key event: NPCs migration. Compounds structurally-related to EGCG induce the same pattern of NPCs migration alterations (decreased migration distance, decreased formation of migration corona, chaotic orientation of cellular processes and decreased migration of neurons at higher concentrations). The potency of the compounds does not depend on the number of galloyl groups, and small structure variations can imply large potency differences. Due to their lower toxicity observed in vitro in NPCs, 4,4′-bis[(3,4,5-trihydroxybenzoyl)oxy]-1,1′-biphenyl and EGCG PEGylated PLGA nanoparticles are suggested as potential future therapeutic or preventive alternatives to EGCG during prenatal periodElsevier Ltd2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/167697Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.fct.2018.10.055Food and Chemical Toxicology, 2019, vol. 123, p. 195-204https://doi.org/10.1016/j.fct.2018.10.055cc-by-nc-nd (c) Elsevier Ltd, 2019http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1676972026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Comparison of Migration Disturbance Potency of Epigallocatechin Gallate (EGCG) Synthetic Analogs and EGCG PEGylated PLGA Nanoparticles in Rat Neurospheres |
| title |
Comparison of Migration Disturbance Potency of Epigallocatechin Gallate (EGCG) Synthetic Analogs and EGCG PEGylated PLGA Nanoparticles in Rat Neurospheres |
| spellingShingle |
Comparison of Migration Disturbance Potency of Epigallocatechin Gallate (EGCG) Synthetic Analogs and EGCG PEGylated PLGA Nanoparticles in Rat Neurospheres Kühne, Britta A. Suplements nutritius Neurotoxicologia Embriologia Dietary supplements Neurotoxicology Embryology |
| title_short |
Comparison of Migration Disturbance Potency of Epigallocatechin Gallate (EGCG) Synthetic Analogs and EGCG PEGylated PLGA Nanoparticles in Rat Neurospheres |
| title_full |
Comparison of Migration Disturbance Potency of Epigallocatechin Gallate (EGCG) Synthetic Analogs and EGCG PEGylated PLGA Nanoparticles in Rat Neurospheres |
| title_fullStr |
Comparison of Migration Disturbance Potency of Epigallocatechin Gallate (EGCG) Synthetic Analogs and EGCG PEGylated PLGA Nanoparticles in Rat Neurospheres |
| title_full_unstemmed |
Comparison of Migration Disturbance Potency of Epigallocatechin Gallate (EGCG) Synthetic Analogs and EGCG PEGylated PLGA Nanoparticles in Rat Neurospheres |
| title_sort |
Comparison of Migration Disturbance Potency of Epigallocatechin Gallate (EGCG) Synthetic Analogs and EGCG PEGylated PLGA Nanoparticles in Rat Neurospheres |
| dc.creator.none.fl_str_mv |
Kühne, Britta A. Puig i Miquel, Teresa Ruiz-Martínez, Santiago Crous-Masó, Joan Planas, Marta Feliu, Lidia Cano Fernández, Amanda García, Maria Luisa Fritsche, Ellen Llobet Mallafré, Joan M. (Joan Maria) Gómez Catalán, Jesús Barenys Espadaler, Marta |
| author |
Kühne, Britta A. |
| author_facet |
Kühne, Britta A. Puig i Miquel, Teresa Ruiz-Martínez, Santiago Crous-Masó, Joan Planas, Marta Feliu, Lidia Cano Fernández, Amanda García, Maria Luisa Fritsche, Ellen Llobet Mallafré, Joan M. (Joan Maria) Gómez Catalán, Jesús Barenys Espadaler, Marta |
| author_role |
author |
| author2 |
Puig i Miquel, Teresa Ruiz-Martínez, Santiago Crous-Masó, Joan Planas, Marta Feliu, Lidia Cano Fernández, Amanda García, Maria Luisa Fritsche, Ellen Llobet Mallafré, Joan M. (Joan Maria) Gómez Catalán, Jesús Barenys Espadaler, Marta |
| author2_role |
author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Suplements nutritius Neurotoxicologia Embriologia Dietary supplements Neurotoxicology Embryology |
| topic |
Suplements nutritius Neurotoxicologia Embriologia Dietary supplements Neurotoxicology Embryology |
| description |
Epigallocatechin gallate (EGCG), the main catechin of green tea, is described to have potential health benefits in several fields like oncology, neurology or cardiology. Currently, it is also under pre-clinical investigation as a potential therapeutic or preventive treatment during pregnancy against developmental adverse effects induced by toxic substances. However, the safety of EGCG during pregnancy is unclear due to its proven adverse effects on neural progenitor cells' (NPCs) migration. As lately several strategies have arisen to generate new therapeutic agents derived from EGCG, we have used the rat 'Neurosphere Assay' to characterize and compare the effects of EGCG structurally related compounds and EGCG PEGylated PLGA nanoparticles on a neurodevelopmental key event: NPCs migration. Compounds structurally-related to EGCG induce the same pattern of NPCs migration alterations (decreased migration distance, decreased formation of migration corona, chaotic orientation of cellular processes and decreased migration of neurons at higher concentrations). The potency of the compounds does not depend on the number of galloyl groups, and small structure variations can imply large potency differences. Due to their lower toxicity observed in vitro in NPCs, 4,4′-bis[(3,4,5-trihydroxybenzoyl)oxy]-1,1′-biphenyl and EGCG PEGylated PLGA nanoparticles are suggested as potential future therapeutic or preventive alternatives to EGCG during prenatal period |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/167697 |
| url |
https://hdl.handle.net/2445/167697 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Versió postprint del document publicat a: https://doi.org/10.1016/j.fct.2018.10.055 Food and Chemical Toxicology, 2019, vol. 123, p. 195-204 https://doi.org/10.1016/j.fct.2018.10.055 |
| dc.rights.none.fl_str_mv |
cc-by-nc-nd (c) Elsevier Ltd, 2019 http://creativecommons.org/licenses/by-nc-nd/3.0/es info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by-nc-nd (c) Elsevier Ltd, 2019 http://creativecommons.org/licenses/by-nc-nd/3.0/es |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier Ltd |
| publisher.none.fl_str_mv |
Elsevier Ltd |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
| instname_str |
Universidad de Barcelona |
| reponame_str |
Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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1869408153484918784 |
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15.300724 |