DNA methylation patterns and epigenetic aging associated with suicide attempts in bipolar disorder.

BACKGROUND: Suicidal thoughts and behaviors (STBs) are a public health issue highly prevalent in bipolar disorder (BD). Multiple factors contribute to STBs, and new evidence highlights the significant role of epigenetics, specifically DNA methylation (DNAm). Additionally, recent studies found accele...

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Autores: Mitjans M, Acosta-Díez M, Giménez-Palomo A, Zafrilla-López M, Saiz PA, Barrot-Feixat C, Jiménez E, Papiol S, Defez J, Xifró-Collsamata A, Ortega-Sánchez M, Ruiz V, Gavín P, García-Portilla MP, González-Blanco L, Bobes J, Schulze TG, Vieta E, Benabarre A, Arias B
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p29066
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29066
Access Level:acceso abierto
Palabra clave:Bipolar disorder
DNA methylation
EWAS
Epigenetic aging
Epigenetic clocks
Suicide attempts
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spelling DNA methylation patterns and epigenetic aging associated with suicide attempts in bipolar disorder.Mitjans MAcosta-Díez MGiménez-Palomo AZafrilla-López MSaiz PABarrot-Feixat CJiménez EPapiol SDefez JXifró-Collsamata AOrtega-Sánchez MRuiz VGavín PGarcía-Portilla MPGonzález-Blanco LBobes JSchulze TGVieta EBenabarre AArias BBipolar disorderDNA methylationEWASEpigenetic agingEpigenetic clocksSuicide attemptsBACKGROUND: Suicidal thoughts and behaviors (STBs) are a public health issue highly prevalent in bipolar disorder (BD). Multiple factors contribute to STBs, and new evidence highlights the significant role of epigenetics, specifically DNA methylation (DNAm). Additionally, recent studies found accelerated epigenetic aging (EA) in both BD and STBs. This study aimed to detect epigenetic risk factors for STBs, particularly for suicide attempts (SAs), comparing DNAm patterns and EA between BD patients with (BD/SA) and without (BD/non-SA) a history of SAs. Moreover, EA was calculated to explore age acceleration (AgeAccel) in the BD/SA group. METHODS: Genome-wide DNAm patterns of blood samples from 46 BD/SA and 32 BD/non-SA were assessed using Infinium HumanMethylationEPIC v1.0 BeadChip (Illumina). Differentially methylated positions (DMPs) and regions (DMRs) were compared between groups. Gene network analysis was performed using genes mapped to DMPs and DMRs. Lastly, EA from different epigenetic clocks was estimated and compared between groups. RESULTS: We identified 18 DMPs and 2 DMRs (adjusted p-value < 0.05) between BD/SA and BD/non-SA. Among the 18 genes mapped to DMPs and DMRs, the MAD1L1 gene was previously associated with severe SAs. Trends of AgeAccel using the GrimAge and GrimAge2 clocks (p-value = 0.022; adjusted p-value > 0.05) were found in BD/SA. LIMITATIONS: Relatively small sample size, cross-sectional design, and use of peripheral blood. CONCLUSIONS: Our findings highlight the importance of considering epigenetic markers when studying SAs in mental disorders. These results may contribute to a better understanding of the biological basis of SAs in BD, which could ultimately help identify at-risk individuals for SAs.ELSEVIER2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29066JOURNAL OF AFFECTIVE DISORDERSISSN: 01650327ISSNe: 15732517reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p290662026-05-27T12:37:41Z
dc.title.none.fl_str_mv DNA methylation patterns and epigenetic aging associated with suicide attempts in bipolar disorder.
title DNA methylation patterns and epigenetic aging associated with suicide attempts in bipolar disorder.
spellingShingle DNA methylation patterns and epigenetic aging associated with suicide attempts in bipolar disorder.
Mitjans M
Bipolar disorder
DNA methylation
EWAS
Epigenetic aging
Epigenetic clocks
Suicide attempts
title_short DNA methylation patterns and epigenetic aging associated with suicide attempts in bipolar disorder.
title_full DNA methylation patterns and epigenetic aging associated with suicide attempts in bipolar disorder.
title_fullStr DNA methylation patterns and epigenetic aging associated with suicide attempts in bipolar disorder.
title_full_unstemmed DNA methylation patterns and epigenetic aging associated with suicide attempts in bipolar disorder.
title_sort DNA methylation patterns and epigenetic aging associated with suicide attempts in bipolar disorder.
dc.creator.none.fl_str_mv Mitjans M
Acosta-Díez M
Giménez-Palomo A
Zafrilla-López M
Saiz PA
Barrot-Feixat C
Jiménez E
Papiol S
Defez J
Xifró-Collsamata A
Ortega-Sánchez M
Ruiz V
Gavín P
García-Portilla MP
González-Blanco L
Bobes J
Schulze TG
Vieta E
Benabarre A
Arias B
author Mitjans M
author_facet Mitjans M
Acosta-Díez M
Giménez-Palomo A
Zafrilla-López M
Saiz PA
Barrot-Feixat C
Jiménez E
Papiol S
Defez J
Xifró-Collsamata A
Ortega-Sánchez M
Ruiz V
Gavín P
García-Portilla MP
González-Blanco L
Bobes J
Schulze TG
Vieta E
Benabarre A
Arias B
author_role author
author2 Acosta-Díez M
Giménez-Palomo A
Zafrilla-López M
Saiz PA
Barrot-Feixat C
Jiménez E
Papiol S
Defez J
Xifró-Collsamata A
Ortega-Sánchez M
Ruiz V
Gavín P
García-Portilla MP
González-Blanco L
Bobes J
Schulze TG
Vieta E
Benabarre A
Arias B
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bipolar disorder
DNA methylation
EWAS
Epigenetic aging
Epigenetic clocks
Suicide attempts
topic Bipolar disorder
DNA methylation
EWAS
Epigenetic aging
Epigenetic clocks
Suicide attempts
description BACKGROUND: Suicidal thoughts and behaviors (STBs) are a public health issue highly prevalent in bipolar disorder (BD). Multiple factors contribute to STBs, and new evidence highlights the significant role of epigenetics, specifically DNA methylation (DNAm). Additionally, recent studies found accelerated epigenetic aging (EA) in both BD and STBs. This study aimed to detect epigenetic risk factors for STBs, particularly for suicide attempts (SAs), comparing DNAm patterns and EA between BD patients with (BD/SA) and without (BD/non-SA) a history of SAs. Moreover, EA was calculated to explore age acceleration (AgeAccel) in the BD/SA group. METHODS: Genome-wide DNAm patterns of blood samples from 46 BD/SA and 32 BD/non-SA were assessed using Infinium HumanMethylationEPIC v1.0 BeadChip (Illumina). Differentially methylated positions (DMPs) and regions (DMRs) were compared between groups. Gene network analysis was performed using genes mapped to DMPs and DMRs. Lastly, EA from different epigenetic clocks was estimated and compared between groups. RESULTS: We identified 18 DMPs and 2 DMRs (adjusted p-value < 0.05) between BD/SA and BD/non-SA. Among the 18 genes mapped to DMPs and DMRs, the MAD1L1 gene was previously associated with severe SAs. Trends of AgeAccel using the GrimAge and GrimAge2 clocks (p-value = 0.022; adjusted p-value > 0.05) were found in BD/SA. LIMITATIONS: Relatively small sample size, cross-sectional design, and use of peripheral blood. CONCLUSIONS: Our findings highlight the importance of considering epigenetic markers when studying SAs in mental disorders. These results may contribute to a better understanding of the biological basis of SAs in BD, which could ultimately help identify at-risk individuals for SAs.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29066
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29066
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER
publisher.none.fl_str_mv ELSEVIER
dc.source.none.fl_str_mv JOURNAL OF AFFECTIVE DISORDERS
ISSN: 01650327
ISSNe: 15732517
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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