Péptidos helicoidales y derivados de chalcona en la búsqueda de moduladores de canales iónicos

Ion channels are key elements of the plasmatic membranes. They are constituted as homo- or heteromeric protein complexes and selectively mediate the ion flux through the lipid bilayer to keep a gradient between both sides of the membrane. Cells make use of this gradient to regulate basic functions a...

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Detalles Bibliográficos
Autor: Balsera Paredes, Beatriz
Tipo de recurso: tesis doctoral
Fecha de publicación:2016
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:español
OAI Identifier:oai:docta.ucm.es:20.500.14352/26856
Acceso en línea:https://hdl.handle.net/20.500.14352/26856
Access Level:acceso abierto
Palabra clave:577.112.6(043.2)
Peptidos
Peptides
Química orgánica (Farmacia)
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spelling Péptidos helicoidales y derivados de chalcona en la búsqueda de moduladores de canales iónicosBalsera Paredes, Beatriz577.112.6(043.2)PeptidosPeptidesQuímica orgánica (Farmacia)Ion channels are key elements of the plasmatic membranes. They are constituted as homo- or heteromeric protein complexes and selectively mediate the ion flux through the lipid bilayer to keep a gradient between both sides of the membrane. Cells make use of this gradient to regulate basic functions and, as a consequence, deregulation or abnormal functioning of ion channels are responsible for severe pathologies. Thus, and as a general approach, the modulation of such ion channels is crucial to treat several pathologies. Many of the explored strategies have been focused on the design of agonists and antagonists. However, alternative methodologies are required to overcome adverse effects associated to the classic design of substrate analogs. In this regard, the design of protein-protein interaction (PPI) and allosteric modulators are current powerful strategies..Universidad Complutense de MadridPérez de Vega, Mª JesúsGonzález Muñiz, RosarioUniversidad Complutense de Madrid20162016-03-0420162016-03-04doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/26856reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Españolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/268562026-06-02T12:44:21Z
dc.title.none.fl_str_mv Péptidos helicoidales y derivados de chalcona en la búsqueda de moduladores de canales iónicos
title Péptidos helicoidales y derivados de chalcona en la búsqueda de moduladores de canales iónicos
spellingShingle Péptidos helicoidales y derivados de chalcona en la búsqueda de moduladores de canales iónicos
Balsera Paredes, Beatriz
577.112.6(043.2)
Peptidos
Peptides
Química orgánica (Farmacia)
title_short Péptidos helicoidales y derivados de chalcona en la búsqueda de moduladores de canales iónicos
title_full Péptidos helicoidales y derivados de chalcona en la búsqueda de moduladores de canales iónicos
title_fullStr Péptidos helicoidales y derivados de chalcona en la búsqueda de moduladores de canales iónicos
title_full_unstemmed Péptidos helicoidales y derivados de chalcona en la búsqueda de moduladores de canales iónicos
title_sort Péptidos helicoidales y derivados de chalcona en la búsqueda de moduladores de canales iónicos
dc.creator.none.fl_str_mv Balsera Paredes, Beatriz
author Balsera Paredes, Beatriz
author_facet Balsera Paredes, Beatriz
author_role author
dc.contributor.none.fl_str_mv Pérez de Vega, Mª Jesús
González Muñiz, Rosario
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.112.6(043.2)
Peptidos
Peptides
Química orgánica (Farmacia)
topic 577.112.6(043.2)
Peptidos
Peptides
Química orgánica (Farmacia)
description Ion channels are key elements of the plasmatic membranes. They are constituted as homo- or heteromeric protein complexes and selectively mediate the ion flux through the lipid bilayer to keep a gradient between both sides of the membrane. Cells make use of this gradient to regulate basic functions and, as a consequence, deregulation or abnormal functioning of ion channels are responsible for severe pathologies. Thus, and as a general approach, the modulation of such ion channels is crucial to treat several pathologies. Many of the explored strategies have been focused on the design of agonists and antagonists. However, alternative methodologies are required to overcome adverse effects associated to the classic design of substrate analogs. In this regard, the design of protein-protein interaction (PPI) and allosteric modulators are current powerful strategies..
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-03-04
2016
2016-03-04
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/26856
url https://hdl.handle.net/20.500.14352/26856
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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