Laponite nanoclays for the sustained delivery of therapeutic proteins

Protein therapeutics hold immense promise for treating a wide array of diseases. However, their efficacy is often compromised by rapid degradation and clearance. The synthetic smectite clay Laponite emerges as a promising candidate for their sustained delivery. Despite its unique properties allow to...

Descripción completa

Detalles Bibliográficos
Autores: González Pujana, Ainhoa, Igartua Olaechea, Manuela, Hernández Martín, Rosa María, Santos Vizcaíno, Edorta
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/69173
Acceso en línea:http://hdl.handle.net/10810/69173
Access Level:acceso abierto
Palabra clave:laponite
nanoclay
drug delivery
protein
hydrogel
id ES_53a2ef5cf3418c7e1306f828b75dd2e9
oai_identifier_str oai:addi.ehu.eus:10810/69173
network_acronym_str ES
network_name_str España
repository_id_str
spelling Laponite nanoclays for the sustained delivery of therapeutic proteinsGonzález Pujana, AinhoaIgartua Olaechea, ManuelaHernández Martín, Rosa MaríaSantos Vizcaíno, Edortalaponitenanoclaydrug deliveryproteinhydrogelProtein therapeutics hold immense promise for treating a wide array of diseases. However, their efficacy is often compromised by rapid degradation and clearance. The synthetic smectite clay Laponite emerges as a promising candidate for their sustained delivery. Despite its unique properties allow to load and release proteins mitigating burst release and extending their effects, precise control over Laponite-protein interactions remains challenging since it depends on a complex interplay of factors whose implication is not fully understood yet. The aim of this review article is to shed light on this issue, providing a comprehensive discussion of the factors influencing protein loading and release, including the physicochemical properties of the nanoclay and proteins, pH, dispersion buffer, clay/protein concentration and Laponite degradation. Furthermore, we thoroughly revise the array of bioactive proteins that have been delivered from formulations containing the nanoclay, highlighting Laponite-polymer nanocomposite hydrogels, a promising avenue currently under extensive investigation.This work was supported by MCIU-Proyectos de Investigación Orientada (PID2021-122577OB-I00) and Eusko Jaurlaritza (Grupos Consolidados IT1448-22). Authors thank ICTS “NANBIOSIS” (Drug Formulation Unit, U10). A. Gonzalez-Pujana thanks the University of the Basque Country (UPV/EHU) for the postdoctoral grant (ESPDOC20/119). Fig. 1 was created with BioRender.com. Open Access funding provided by University of Basque Country (UPV/EHU).Elsevier202420242024info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/69173reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MICINN/PID2021-122577OB-I00/https://www.sciencedirect.com/science/article/pii/S0928098724001702info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/3.0/es/© 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC license.Atribución-NoComercial 3.0 Españaoai:addi.ehu.eus:10810/691732026-06-18T09:23:17Z
dc.title.none.fl_str_mv Laponite nanoclays for the sustained delivery of therapeutic proteins
title Laponite nanoclays for the sustained delivery of therapeutic proteins
spellingShingle Laponite nanoclays for the sustained delivery of therapeutic proteins
González Pujana, Ainhoa
laponite
nanoclay
drug delivery
protein
hydrogel
title_short Laponite nanoclays for the sustained delivery of therapeutic proteins
title_full Laponite nanoclays for the sustained delivery of therapeutic proteins
title_fullStr Laponite nanoclays for the sustained delivery of therapeutic proteins
title_full_unstemmed Laponite nanoclays for the sustained delivery of therapeutic proteins
title_sort Laponite nanoclays for the sustained delivery of therapeutic proteins
dc.creator.none.fl_str_mv González Pujana, Ainhoa
Igartua Olaechea, Manuela
Hernández Martín, Rosa María
Santos Vizcaíno, Edorta
author González Pujana, Ainhoa
author_facet González Pujana, Ainhoa
Igartua Olaechea, Manuela
Hernández Martín, Rosa María
Santos Vizcaíno, Edorta
author_role author
author2 Igartua Olaechea, Manuela
Hernández Martín, Rosa María
Santos Vizcaíno, Edorta
author2_role author
author
author
dc.subject.none.fl_str_mv laponite
nanoclay
drug delivery
protein
hydrogel
topic laponite
nanoclay
drug delivery
protein
hydrogel
description Protein therapeutics hold immense promise for treating a wide array of diseases. However, their efficacy is often compromised by rapid degradation and clearance. The synthetic smectite clay Laponite emerges as a promising candidate for their sustained delivery. Despite its unique properties allow to load and release proteins mitigating burst release and extending their effects, precise control over Laponite-protein interactions remains challenging since it depends on a complex interplay of factors whose implication is not fully understood yet. The aim of this review article is to shed light on this issue, providing a comprehensive discussion of the factors influencing protein loading and release, including the physicochemical properties of the nanoclay and proteins, pH, dispersion buffer, clay/protein concentration and Laponite degradation. Furthermore, we thoroughly revise the array of bioactive proteins that have been delivered from formulations containing the nanoclay, highlighting Laponite-polymer nanocomposite hydrogels, a promising avenue currently under extensive investigation.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/69173
url http://hdl.handle.net/10810/69173
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN/PID2021-122577OB-I00/
https://www.sciencedirect.com/science/article/pii/S0928098724001702
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/3.0/es/
Atribución-NoComercial 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/3.0/es/
Atribución-NoComercial 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408130088042496
score 15.811543

Similares en LA Referencia