Efectivitat del cribratge bioquimic de segon trimestre i de l'ecografia de les 20 setmanes en el diagnòstic prenatal de les anomalies cromosòmiques i morfològiques fetals en una població general de gestants
Congenital anomalies are currently the second cause of perinatal and infantile morbidity and mortality in Catalonia.The Catalan Programme of Prenatal Diagnosis of Congenital Anomalies, implemented in 1997, recommends: 1) biochemical screening using the double test (alpha-fetoprotein and β-h...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2008 |
| País: | España |
| Institución: | Universitat Rovira i virgili (URV) |
| Repositorio: | Repositori Institucional de la Universitat Rovira i Virgili |
| OAI Identifier: | oai:urv.cat:TDX:637 |
| Acceso en línea: | https://hdl.handle.net/20.500.11797/TDX637 http://hdl.handle.net/10803/8859 |
| Access Level: | acceso abierto |
| Palabra clave: | 618 - Ginecologia. Obstetricia 61 - Medicina |
| Sumario: | Congenital anomalies are currently the second cause of perinatal and infantile morbidity and mortality in Catalonia.The Catalan Programme of Prenatal Diagnosis of Congenital Anomalies, implemented in 1997, recommends: 1) biochemical screening using the double test (alpha-fetoprotein and β-hCG) to estimate the risks for both trisomy 21(T21) and open neural tube defects (NTD); 2) ultrasound screening by means of the anomaly scan at 20 weeks' gestation and 3) offering an invasive procedure to pregnant women with a high risk for chromosomal anomalies.Objective Evaluate the effectiveness of the Catalan Programme of Prenatal Diagnosis of Congenital Anomalies applied in the Health Plan for 1996-98 in a general population of pregnant women.HypothesisSecond trimester biochemical screening together with the anomaly scan at 20 weeks allow for the prenatal diagnosis of more than 60% of T21 and more than 50 % of detectable structural anomalies.Material and MethodsThis is a prospective cohort including all the fetuses screened by biochemistry or ultrasound in the public health system during a 3-year period.This is a population-based study, in which the study population was formed by the pregnant women attending the 5 health basic areas (ABS) assigned to the Hospital de Sant Pau i Santa Tecla of Tarragona.The fetal anomalies included in the study were all: 1.Clinically relevant chromosomal anomalies, in which termination of pregnancy may be considered as a means of secondary prevention to improve the perinatal and infantile morbidity and mortality;2.Detectable structural anomalies at the 20 weeks' scan (adopting the EUROCAT classification established by this European network of population-based registries for the epidemiologic surveillance of congenital anomalies)Structural anom |
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