Emerging Role of MDSCS as Novel Biomarkers and Therapeutic Targets for Cancer Immunotherapy

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that accumulate under pathological conditions such as cancer, where they contribute to immune evasion, tumor progression, and resistance to therapy. These cells exert potent immunosuppressive effects by...

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Autores: Silva-Romeiro, S, Flores-Campos, Rocío, Sánchez-León, María L., Sánchez-Margalet, Víctor, Cruz-Merino, Luis de la
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/412919
Acesso em linha:http://hdl.handle.net/10261/412919
https://api.elsevier.com/content/abstract/scopus_id/105021397245
Access Level:Acceso aberto
Palavra-chave:Immune biomarkers
Immunotherapy
Myeloid-derived suppressor cells
Tumor microenvironment
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spelling Emerging Role of MDSCS as Novel Biomarkers and Therapeutic Targets for Cancer ImmunotherapySilva-Romeiro, SFlores-Campos, RocíoSánchez-León, María L.Sánchez-Margalet, VíctorCruz-Merino, Luis de laImmune biomarkersImmunotherapyMyeloid-derived suppressor cellsTumor microenvironmentMyeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that accumulate under pathological conditions such as cancer, where they contribute to immune evasion, tumor progression, and resistance to therapy. These cells exert potent immunosuppressive effects by inhibiting T cell activation, inducing regulatory T cells, modulating antigen-presenting cells, and shaping an immunosuppressive tumor microenvironment (TME). Their suppressive functions involve multiple mechanisms, including amino acid depletion, production of reactive oxygen and nitrogen species, expression of immune checkpoint ligands, and secretion of immunoregulatory cytokines such as IL-10 and TGF-β. Besides these immune-related roles, MDSCs also promote tumor growth through non-immunological mechanisms, including the stimulation of angiogenesis and undergoing metabolic reprogramming. These adaptations support their survival and function in the hostile TME. Given their multifaceted role in cancer, MDSCs represent a promising target for therapeutic intervention. Furthermore, their abundance and dynamic modulation during treatment confer them tremendous potential as biomarkers to monitor therapy efficacy and stratify patients. This review provides a comprehensive overview of MDSC biology, their mechanisms of action, and their emerging clinical relevance as biomarkers and therapeutic targets. We also explore current strategies aimed at targeting MDSCs, including their depletion, inhibition of recruitment, functional blockade, and promotion of their differentiation into mature myeloid cells. Integrating these approaches with existing cancer therapies holds great promise for enhancing antitumor immunity and overcoming resistance in both solid tumors and hematologic malignancies.Peer reviewedTaylor & FrancisDove PressSánchez-Margalet, Víctor [0000-0001-8638-8680]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/412919https://api.elsevier.com/content/abstract/scopus_id/105021397245reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.2147/ITT.S485642Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4129192026-05-22T06:33:51Z
dc.title.none.fl_str_mv Emerging Role of MDSCS as Novel Biomarkers and Therapeutic Targets for Cancer Immunotherapy
title Emerging Role of MDSCS as Novel Biomarkers and Therapeutic Targets for Cancer Immunotherapy
spellingShingle Emerging Role of MDSCS as Novel Biomarkers and Therapeutic Targets for Cancer Immunotherapy
Silva-Romeiro, S
Immune biomarkers
Immunotherapy
Myeloid-derived suppressor cells
Tumor microenvironment
title_short Emerging Role of MDSCS as Novel Biomarkers and Therapeutic Targets for Cancer Immunotherapy
title_full Emerging Role of MDSCS as Novel Biomarkers and Therapeutic Targets for Cancer Immunotherapy
title_fullStr Emerging Role of MDSCS as Novel Biomarkers and Therapeutic Targets for Cancer Immunotherapy
title_full_unstemmed Emerging Role of MDSCS as Novel Biomarkers and Therapeutic Targets for Cancer Immunotherapy
title_sort Emerging Role of MDSCS as Novel Biomarkers and Therapeutic Targets for Cancer Immunotherapy
dc.creator.none.fl_str_mv Silva-Romeiro, S
Flores-Campos, Rocío
Sánchez-León, María L.
Sánchez-Margalet, Víctor
Cruz-Merino, Luis de la
author Silva-Romeiro, S
author_facet Silva-Romeiro, S
Flores-Campos, Rocío
Sánchez-León, María L.
Sánchez-Margalet, Víctor
Cruz-Merino, Luis de la
author_role author
author2 Flores-Campos, Rocío
Sánchez-León, María L.
Sánchez-Margalet, Víctor
Cruz-Merino, Luis de la
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Sánchez-Margalet, Víctor [0000-0001-8638-8680]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Immune biomarkers
Immunotherapy
Myeloid-derived suppressor cells
Tumor microenvironment
topic Immune biomarkers
Immunotherapy
Myeloid-derived suppressor cells
Tumor microenvironment
description Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that accumulate under pathological conditions such as cancer, where they contribute to immune evasion, tumor progression, and resistance to therapy. These cells exert potent immunosuppressive effects by inhibiting T cell activation, inducing regulatory T cells, modulating antigen-presenting cells, and shaping an immunosuppressive tumor microenvironment (TME). Their suppressive functions involve multiple mechanisms, including amino acid depletion, production of reactive oxygen and nitrogen species, expression of immune checkpoint ligands, and secretion of immunoregulatory cytokines such as IL-10 and TGF-β. Besides these immune-related roles, MDSCs also promote tumor growth through non-immunological mechanisms, including the stimulation of angiogenesis and undergoing metabolic reprogramming. These adaptations support their survival and function in the hostile TME. Given their multifaceted role in cancer, MDSCs represent a promising target for therapeutic intervention. Furthermore, their abundance and dynamic modulation during treatment confer them tremendous potential as biomarkers to monitor therapy efficacy and stratify patients. This review provides a comprehensive overview of MDSC biology, their mechanisms of action, and their emerging clinical relevance as biomarkers and therapeutic targets. We also explore current strategies aimed at targeting MDSCs, including their depletion, inhibition of recruitment, functional blockade, and promotion of their differentiation into mature myeloid cells. Integrating these approaches with existing cancer therapies holds great promise for enhancing antitumor immunity and overcoming resistance in both solid tumors and hematologic malignancies.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/412919
https://api.elsevier.com/content/abstract/scopus_id/105021397245
url http://hdl.handle.net/10261/412919
https://api.elsevier.com/content/abstract/scopus_id/105021397245
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.2147/ITT.S485642
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
Dove Press
publisher.none.fl_str_mv Taylor & Francis
Dove Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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