HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort

The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocardi...

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Autores: Chambers, Stephen T., Murdoch, David, Morris, Arthur, Holland, David, Pappas, Paul, Almela, M. (Manel), Fernández Hidalgo, Nuria, Almirante, Benito, Bouza, Emilio, Forno, Davide, Rio, Ana del, Hannan, Margaret M., Harkness, Jonh, Kanafani, Zeinha A., Lalani, Tahaniyat, Lang, Selwyn, Raymond, Nigel, Read, Kerry, Vinogradova, Tatiana, Woods, Christopher W, Wray, Dannah, Corey, G. Ralph, Chu, Vivian H., Sitges Carreño, Marta, Miró Meda, José M. (José María), 1956-, Moreno Camacho, Ma. Asunción, Anguera Camós, Ignasi, International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/147838
Acceso en línea:https://hdl.handle.net/2445/147838
Access Level:acceso abierto
Palabra clave:Endocarditis
Control d'infeccions
Infection control
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spelling HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohortChambers, Stephen T.Murdoch, DavidMorris, ArthurHolland, DavidPappas, PaulAlmela, M. (Manel)Fernández Hidalgo, NuriaAlmirante, BenitoBouza, EmilioForno, DavideRio, Ana delHannan, Margaret M.Harkness, JonhKanafani, Zeinha A.Lalani, TahaniyatLang, SelwynRaymond, NigelRead, KerryVinogradova, TatianaWoods, Christopher WWray, DannahCorey, G. RalphChu, Vivian H.Sitges Carreño, MartaMiró Meda, José M. (José María), 1956-Moreno Camacho, Ma. AsunciónAnguera Camós, IgnasiInternational Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) InvestigatorsEndocarditisControl d'infeccionsEndocarditisInfection controlThe HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p<0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p<0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p<0.01) and younger age (OR 0.62; CI 0.49-0.90; p<0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p<0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences.Public Library of Science (PLoS)2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/147838Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0063181PLoS One, 2013, vol. 8, num. 5, p. e63181https://doi.org/10.1371/journal.pone.0063181cc-by (c) Chambers, Stephen T. et al., 2013http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1478382026-05-27T06:46:51Z
dc.title.none.fl_str_mv HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort
title HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort
spellingShingle HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort
Chambers, Stephen T.
Endocarditis
Control d'infeccions
Endocarditis
Infection control
title_short HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort
title_full HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort
title_fullStr HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort
title_full_unstemmed HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort
title_sort HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort
dc.creator.none.fl_str_mv Chambers, Stephen T.
Murdoch, David
Morris, Arthur
Holland, David
Pappas, Paul
Almela, M. (Manel)
Fernández Hidalgo, Nuria
Almirante, Benito
Bouza, Emilio
Forno, Davide
Rio, Ana del
Hannan, Margaret M.
Harkness, Jonh
Kanafani, Zeinha A.
Lalani, Tahaniyat
Lang, Selwyn
Raymond, Nigel
Read, Kerry
Vinogradova, Tatiana
Woods, Christopher W
Wray, Dannah
Corey, G. Ralph
Chu, Vivian H.
Sitges Carreño, Marta
Miró Meda, José M. (José María), 1956-
Moreno Camacho, Ma. Asunción
Anguera Camós, Ignasi
International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators
author Chambers, Stephen T.
author_facet Chambers, Stephen T.
Murdoch, David
Morris, Arthur
Holland, David
Pappas, Paul
Almela, M. (Manel)
Fernández Hidalgo, Nuria
Almirante, Benito
Bouza, Emilio
Forno, Davide
Rio, Ana del
Hannan, Margaret M.
Harkness, Jonh
Kanafani, Zeinha A.
Lalani, Tahaniyat
Lang, Selwyn
Raymond, Nigel
Read, Kerry
Vinogradova, Tatiana
Woods, Christopher W
Wray, Dannah
Corey, G. Ralph
Chu, Vivian H.
Sitges Carreño, Marta
Miró Meda, José M. (José María), 1956-
Moreno Camacho, Ma. Asunción
Anguera Camós, Ignasi
International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators
author_role author
author2 Murdoch, David
Morris, Arthur
Holland, David
Pappas, Paul
Almela, M. (Manel)
Fernández Hidalgo, Nuria
Almirante, Benito
Bouza, Emilio
Forno, Davide
Rio, Ana del
Hannan, Margaret M.
Harkness, Jonh
Kanafani, Zeinha A.
Lalani, Tahaniyat
Lang, Selwyn
Raymond, Nigel
Read, Kerry
Vinogradova, Tatiana
Woods, Christopher W
Wray, Dannah
Corey, G. Ralph
Chu, Vivian H.
Sitges Carreño, Marta
Miró Meda, José M. (José María), 1956-
Moreno Camacho, Ma. Asunción
Anguera Camós, Ignasi
International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Endocarditis
Control d'infeccions
Endocarditis
Infection control
topic Endocarditis
Control d'infeccions
Endocarditis
Infection control
description The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p<0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p<0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p<0.01) and younger age (OR 0.62; CI 0.49-0.90; p<0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p<0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/147838
url https://hdl.handle.net/2445/147838
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0063181
PLoS One, 2013, vol. 8, num. 5, p. e63181
https://doi.org/10.1371/journal.pone.0063181
dc.rights.none.fl_str_mv cc-by (c) Chambers, Stephen T. et al., 2013
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Chambers, Stephen T. et al., 2013
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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