Influence of sex on the timing of coronary angiography and the prescription of antiplatelet therapy in patients with nonST-segment elevation myocardial infarction

Objective. To assess differences in the clinical management of nonST-segment elevation myocardial infarction (NSTEMI), including in-hospital events, according to biological sex. Methods. Prospective observational multicenter study of patients diagnosed with NSTEMI and atherosclerosis who underwent c...

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Autores: Martínez-Guisado, A, Cepas-Guillén, P, Díez-Villanueva, P, Lluva, MTL, Jurado-Román, A, Bazal-Chacón, P, Negreira-Caamaño, M, Olavarri-Miguel, I, Elorriaga, A, Rivera-López, R, Escribano, D, Salinas, P, Vaquero-Luna, J, Prieto, A, Pérez-Cebey, L, Carrasquer, A, Llaó, I, Mezcúa, FJT, Giralt-Borrell, T, Matute-Blanco, L, Fernández-Cordón, C, González, C, Arbas-Redondo, E, Aritza-Conty, D, Díez-Delhoyo, F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p17825
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/17825
Access Level:acceso abierto
Palabra clave:Ischemic heart disease
Acute coronary syndrome
Acute myocardial infarction
NonST-segment elevation
Antiplatelet therapy
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spelling Influence of sex on the timing of coronary angiography and the prescription of antiplatelet therapy in patients with nonST-segment elevation myocardial infarctionMartínez-Guisado, ACepas-Guillén, PDíez-Villanueva, PLluva, MTLJurado-Román, ABazal-Chacón, PNegreira-Caamaño, MOlavarri-Miguel, IElorriaga, ARivera-López, REscribano, DSalinas, PVaquero-Luna, JPrieto, APérez-Cebey, LCarrasquer, ALlaó, IMezcúa, FJTGiralt-Borrell, TMatute-Blanco, LFernández-Cordón, CGonzález, CArbas-Redondo, EAritza-Conty, DDíez-Delhoyo, FIschemic heart diseaseAcute coronary syndromeAcute myocardial infarctionNonST-segment elevationAntiplatelet therapyObjective. To assess differences in the clinical management of nonST-segment elevation myocardial infarction (NSTEMI), including in-hospital events, according to biological sex. Methods. Prospective observational multicenter study of patients diagnosed with NSTEMI and atherosclerosis who underwent coronary angiography. Results. We enrolled 1020 patients in April and May 2022; 240 (23.5%) were women. Women were older than men on average (72.6 vs 66.5 years, P <.001), and more women were frail (17.1% vs 5.6%, P <.001). No difference was observed in pretreatment with any P2Y12 inhibitor (prescribed in 68.8% of women vs 70.2% of men, P =.67); however, more women than men were prescribed clopidogrel (56% vs 44%, P =.009). Women prescribed clopidogrel were more often under the age of 75 years and not frail. Coronary angiography was performed within 24 hours less often in women (29.8% vs 36.9%, P =.03) even when high risk was recognized. Frailty was independently associated with deferring coronary angiography in the adjusted analysis; biological sex by itself was not related. The frequency and type of revascularization were the same in both sexes, and there were no differences in in-hospital cardiovascular events. Conclusions. Women were more often prescribed less potent antithrombotic therapy than men. Frailty, but not sex, correlated independently with deferral of coronary angiography. However, we detected no differences in the frequency of coronary revascularization or in-hospital events according to sex.Soc Espanola Medicina Urgencias & Emergencias-SEMES2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/17825EmergenciasISSN: 11376821ISSNe: 23865857reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Españolinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p178252026-06-11T12:45:17Z
dc.title.none.fl_str_mv Influence of sex on the timing of coronary angiography and the prescription of antiplatelet therapy in patients with nonST-segment elevation myocardial infarction
title Influence of sex on the timing of coronary angiography and the prescription of antiplatelet therapy in patients with nonST-segment elevation myocardial infarction
spellingShingle Influence of sex on the timing of coronary angiography and the prescription of antiplatelet therapy in patients with nonST-segment elevation myocardial infarction
Martínez-Guisado, A
Ischemic heart disease
Acute coronary syndrome
Acute myocardial infarction
NonST-segment elevation
Antiplatelet therapy
title_short Influence of sex on the timing of coronary angiography and the prescription of antiplatelet therapy in patients with nonST-segment elevation myocardial infarction
title_full Influence of sex on the timing of coronary angiography and the prescription of antiplatelet therapy in patients with nonST-segment elevation myocardial infarction
title_fullStr Influence of sex on the timing of coronary angiography and the prescription of antiplatelet therapy in patients with nonST-segment elevation myocardial infarction
title_full_unstemmed Influence of sex on the timing of coronary angiography and the prescription of antiplatelet therapy in patients with nonST-segment elevation myocardial infarction
title_sort Influence of sex on the timing of coronary angiography and the prescription of antiplatelet therapy in patients with nonST-segment elevation myocardial infarction
dc.creator.none.fl_str_mv Martínez-Guisado, A
Cepas-Guillén, P
Díez-Villanueva, P
Lluva, MTL
Jurado-Román, A
Bazal-Chacón, P
Negreira-Caamaño, M
Olavarri-Miguel, I
Elorriaga, A
Rivera-López, R
Escribano, D
Salinas, P
Vaquero-Luna, J
Prieto, A
Pérez-Cebey, L
Carrasquer, A
Llaó, I
Mezcúa, FJT
Giralt-Borrell, T
Matute-Blanco, L
Fernández-Cordón, C
González, C
Arbas-Redondo, E
Aritza-Conty, D
Díez-Delhoyo, F
author Martínez-Guisado, A
author_facet Martínez-Guisado, A
Cepas-Guillén, P
Díez-Villanueva, P
Lluva, MTL
Jurado-Román, A
Bazal-Chacón, P
Negreira-Caamaño, M
Olavarri-Miguel, I
Elorriaga, A
Rivera-López, R
Escribano, D
Salinas, P
Vaquero-Luna, J
Prieto, A
Pérez-Cebey, L
Carrasquer, A
Llaó, I
Mezcúa, FJT
Giralt-Borrell, T
Matute-Blanco, L
Fernández-Cordón, C
González, C
Arbas-Redondo, E
Aritza-Conty, D
Díez-Delhoyo, F
author_role author
author2 Cepas-Guillén, P
Díez-Villanueva, P
Lluva, MTL
Jurado-Román, A
Bazal-Chacón, P
Negreira-Caamaño, M
Olavarri-Miguel, I
Elorriaga, A
Rivera-López, R
Escribano, D
Salinas, P
Vaquero-Luna, J
Prieto, A
Pérez-Cebey, L
Carrasquer, A
Llaó, I
Mezcúa, FJT
Giralt-Borrell, T
Matute-Blanco, L
Fernández-Cordón, C
González, C
Arbas-Redondo, E
Aritza-Conty, D
Díez-Delhoyo, F
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ischemic heart disease
Acute coronary syndrome
Acute myocardial infarction
NonST-segment elevation
Antiplatelet therapy
topic Ischemic heart disease
Acute coronary syndrome
Acute myocardial infarction
NonST-segment elevation
Antiplatelet therapy
description Objective. To assess differences in the clinical management of nonST-segment elevation myocardial infarction (NSTEMI), including in-hospital events, according to biological sex. Methods. Prospective observational multicenter study of patients diagnosed with NSTEMI and atherosclerosis who underwent coronary angiography. Results. We enrolled 1020 patients in April and May 2022; 240 (23.5%) were women. Women were older than men on average (72.6 vs 66.5 years, P <.001), and more women were frail (17.1% vs 5.6%, P <.001). No difference was observed in pretreatment with any P2Y12 inhibitor (prescribed in 68.8% of women vs 70.2% of men, P =.67); however, more women than men were prescribed clopidogrel (56% vs 44%, P =.009). Women prescribed clopidogrel were more often under the age of 75 years and not frail. Coronary angiography was performed within 24 hours less often in women (29.8% vs 36.9%, P =.03) even when high risk was recognized. Frailty was independently associated with deferring coronary angiography in the adjusted analysis; biological sex by itself was not related. The frequency and type of revascularization were the same in both sexes, and there were no differences in in-hospital cardiovascular events. Conclusions. Women were more often prescribed less potent antithrombotic therapy than men. Frailty, but not sex, correlated independently with deferral of coronary angiography. However, we detected no differences in the frequency of coronary revascularization or in-hospital events according to sex.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/17825
url https://fisabio.portalinvestigacion.com/publicaciones/17825
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Soc Espanola Medicina Urgencias & Emergencias-SEMES
publisher.none.fl_str_mv Soc Espanola Medicina Urgencias & Emergencias-SEMES
dc.source.none.fl_str_mv Emergencias
ISSN: 11376821
ISSNe: 23865857
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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