Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review

The efficacy of current standard chemotherapy is suboptimal due to the poor solubility and short half-lives of chemotherapeutic agents, as well as their high toxicity and lack of specificity which may result in severe side effects, noncompliance and patient inconvenience. The application of nanotech...

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Detalhes bibliográficos
Autores: Haider, Mohamed, Abdin, Shifaa M., Kamal, Leena, Orive Arroyo, Gorka
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/42770
Acesso em linha:http://hdl.handle.net/10810/42770
Access Level:acceso abierto
Palavra-chave:nanostructured lipid carriers
chemotherapeutic agents
drug delivery systems
drug targeting
lipid-based nanoparticles
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spelling Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A ReviewHaider, MohamedAbdin, Shifaa M.Kamal, LeenaOrive Arroyo, Gorkananostructured lipid carrierschemotherapeutic agentsdrug delivery systemsdrug targetinglipid-based nanoparticlesThe efficacy of current standard chemotherapy is suboptimal due to the poor solubility and short half-lives of chemotherapeutic agents, as well as their high toxicity and lack of specificity which may result in severe side effects, noncompliance and patient inconvenience. The application of nanotechnology has revolutionized the pharmaceutical industry and attracted increasing attention as a significant means for optimizing the delivery of chemotherapeutic agents and enhancing their efficiency and safety profiles. Nanostructured lipid carriers (NLCs) are lipid-based formulations that have been broadly studied as drug delivery systems. They have a solid matrix at room temperature and are considered superior to many other traditional lipid-based nanocarriers such as nanoemulsions, liposomes and solid lipid nanoparticles (SLNs) due to their enhanced physical stability, improved drug loading capacity, and biocompatibility. This review focuses on the latest advances in the use of NLCs as drug delivery systems and their preparation and characterization techniques with special emphasis on their applications as delivery systems for chemotherapeutic agents and different strategies for their use in tumor targeting.This research was funded by Aljalila foundation, grant number AJF201777.MDPI2020202020202020info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/42770reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.mdpi.com/1999-4923/12/3/288info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).oai:addi.ehu.eus:10810/427702026-06-18T09:23:17Z
dc.title.none.fl_str_mv Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review
title Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review
spellingShingle Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review
Haider, Mohamed
nanostructured lipid carriers
chemotherapeutic agents
drug delivery systems
drug targeting
lipid-based nanoparticles
title_short Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review
title_full Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review
title_fullStr Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review
title_full_unstemmed Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review
title_sort Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review
dc.creator.none.fl_str_mv Haider, Mohamed
Abdin, Shifaa M.
Kamal, Leena
Orive Arroyo, Gorka
author Haider, Mohamed
author_facet Haider, Mohamed
Abdin, Shifaa M.
Kamal, Leena
Orive Arroyo, Gorka
author_role author
author2 Abdin, Shifaa M.
Kamal, Leena
Orive Arroyo, Gorka
author2_role author
author
author
dc.subject.none.fl_str_mv nanostructured lipid carriers
chemotherapeutic agents
drug delivery systems
drug targeting
lipid-based nanoparticles
topic nanostructured lipid carriers
chemotherapeutic agents
drug delivery systems
drug targeting
lipid-based nanoparticles
description The efficacy of current standard chemotherapy is suboptimal due to the poor solubility and short half-lives of chemotherapeutic agents, as well as their high toxicity and lack of specificity which may result in severe side effects, noncompliance and patient inconvenience. The application of nanotechnology has revolutionized the pharmaceutical industry and attracted increasing attention as a significant means for optimizing the delivery of chemotherapeutic agents and enhancing their efficiency and safety profiles. Nanostructured lipid carriers (NLCs) are lipid-based formulations that have been broadly studied as drug delivery systems. They have a solid matrix at room temperature and are considered superior to many other traditional lipid-based nanocarriers such as nanoemulsions, liposomes and solid lipid nanoparticles (SLNs) due to their enhanced physical stability, improved drug loading capacity, and biocompatibility. This review focuses on the latest advances in the use of NLCs as drug delivery systems and their preparation and characterization techniques with special emphasis on their applications as delivery systems for chemotherapeutic agents and different strategies for their use in tumor targeting.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/42770
url http://hdl.handle.net/10810/42770
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/1999-4923/12/3/288
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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