Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study)

Moya, Pedro; Soriano-Irigaray, Leticia; Manuel Ramirez, Jose; Garcea, Alessandro; Blasco, Olga; Javier Blanco, Francisco; Brugiotti, Carlo; Miranda, Elena; Arroyo, Antonio

Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study)

To compare immunonutrition versus standard high calorie nutrition in patients undergoing elective colorectal resection within an Enhanced Recovery After Surgery (ERAS) program.Despite progress in recent years in the surgical management of patients with colorectal cancer (ERAS programs), postoperativ...

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Autores:	Moya, Pedro, Soriano-Irigaray, Leticia, Manuel Ramirez, Jose, Garcea, Alessandro, Blasco, Olga, Javier Blanco, Francisco, Brugiotti, Carlo, Miranda, Elena, Arroyo, Antonio
Tipo de recurso:	artículo
Fecha de publicación:	2016
País:	España
Institución:	Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:	Docusalut
Idioma:	inglés
OAI Identifier:	oai:docusalut.com:20.500.13003/15251
Acceso en línea:	https://hdl.handle.net/20.500.13003/15251
Access Level:	acceso abierto
Palabra clave:	Prospective Studies Male Middle Aged Colorectal Surgery Aged, 80 and over Perioperative Care Aged Clinical Protocols Dietary Supplements Surgical Wound Infection Colorectal Neoplasms Female Spain Postoperative Complications Humans Length of Stay Adult Complicaciones Posoperatorias España Suplementos Dietéticos Adulto Cirugía Colorrectal Anciano de 80 o más Años Atención Perioperativa Anciano Estudios Prospectivos Protocolos Clínicos Persona de Mediana Edad Humanos Tiempo de Internación Masculino Femenino Infección de la Herida Quirúrgica Neoplasias Colorrectales

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spelling	Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study)Moya, PedroSoriano-Irigaray, LeticiaManuel Ramirez, JoseGarcea, AlessandroBlasco, OlgaJavier Blanco, FranciscoBrugiotti, CarloMiranda, ElenaArroyo, AntonioProspective StudiesMaleMiddle AgedColorectal SurgeryAged, 80 and overPerioperative CareAgedClinical ProtocolsDietary SupplementsSurgical Wound InfectionColorectal NeoplasmsFemaleSpainPostoperative ComplicationsHumansLength of StayAdultAged, 80 and overComplicaciones PosoperatoriasEspañaSuplementos DietéticosAdultoCirugía ColorrectalAnciano de 80 o más AñosAtención PerioperativaAncianoEstudios ProspectivosProtocolos ClínicosPersona de Mediana EdadHumanosTiempo de InternaciónMasculinoFemeninoInfección de la Herida QuirúrgicaNeoplasias ColorrectalesTo compare immunonutrition versus standard high calorie nutrition in patients undergoing elective colorectal resection within an Enhanced Recovery After Surgery (ERAS) program.Despite progress in recent years in the surgical management of patients with colorectal cancer (ERAS programs), postoperative complications are frequent. Nutritional supplements enriched with immunonutrients have recently been introduced into clinical practice. However, the extent to which the combination of ERAS protocols and immunonutrition benefits patients undergoing colorectal cancer surgery is unknown.The SONVI study is a prospective, multicenter, randomized trial with 2 parallel treatment groups receiving either the study product (an immune-enhancing feed) or the control supplement (a hypercaloric hypernitrogenous supplement) for 7 days before colorectal resection and 5 days postoperatively.A total of 264 patients were randomized. At baseline, both groups were comparable in regards to age, sex, surgical risk, comorbidity, and analytical and nutritional parameters. The median length of the postoperative hospital stay was 5 days with no differences between the groups. A decrease in the total number of complications was observed in the immunonutrition group compared with the control group, primarily due to a significant decrease in infectious complications (23.8% vs. 10.7%, P=0.0007). Of the infectious complications, wound infection differed significantly between the groups (16.4% vs. 5.7%, P=0.0008). Other infectious complications were lower in the immunonutrition group but were not statistically significantly different.The implementation of ERAS protocols including immunonutrient-enriched supplements reduces the complications of patients undergoing colorectal resection.This study is registered with ClinicalTrial.gov: NCT02393976.Lippincott Williams & Wilkins20162016-05-0120162016-05-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/15251reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/152512026-06-22T12:44:07Z
dc.title.none.fl_str_mv	Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study)
title	Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study)
spellingShingle	Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study) Moya, Pedro Prospective Studies Male Middle Aged Colorectal Surgery Aged, 80 and over Perioperative Care Aged Clinical Protocols Dietary Supplements Surgical Wound Infection Colorectal Neoplasms Female Spain Postoperative Complications Humans Length of Stay Adult Aged, 80 and over Complicaciones Posoperatorias España Suplementos Dietéticos Adulto Cirugía Colorrectal Anciano de 80 o más Años Atención Perioperativa Anciano Estudios Prospectivos Protocolos Clínicos Persona de Mediana Edad Humanos Tiempo de Internación Masculino Femenino Infección de la Herida Quirúrgica Neoplasias Colorrectales
title_short	Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study)
title_full	Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study)
title_fullStr	Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study)
title_full_unstemmed	Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study)
title_sort	Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study)
dc.creator.none.fl_str_mv	Moya, Pedro Soriano-Irigaray, Leticia Manuel Ramirez, Jose Garcea, Alessandro Blasco, Olga Javier Blanco, Francisco Brugiotti, Carlo Miranda, Elena Arroyo, Antonio
author	Moya, Pedro
author_facet	Moya, Pedro Soriano-Irigaray, Leticia Manuel Ramirez, Jose Garcea, Alessandro Blasco, Olga Javier Blanco, Francisco Brugiotti, Carlo Miranda, Elena Arroyo, Antonio
author_role	author
author2	Soriano-Irigaray, Leticia Manuel Ramirez, Jose Garcea, Alessandro Blasco, Olga Javier Blanco, Francisco Brugiotti, Carlo Miranda, Elena Arroyo, Antonio
author2_role	author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Prospective Studies Male Middle Aged Colorectal Surgery Aged, 80 and over Perioperative Care Aged Clinical Protocols Dietary Supplements Surgical Wound Infection Colorectal Neoplasms Female Spain Postoperative Complications Humans Length of Stay Adult Aged, 80 and over Complicaciones Posoperatorias España Suplementos Dietéticos Adulto Cirugía Colorrectal Anciano de 80 o más Años Atención Perioperativa Anciano Estudios Prospectivos Protocolos Clínicos Persona de Mediana Edad Humanos Tiempo de Internación Masculino Femenino Infección de la Herida Quirúrgica Neoplasias Colorrectales
topic	Prospective Studies Male Middle Aged Colorectal Surgery Aged, 80 and over Perioperative Care Aged Clinical Protocols Dietary Supplements Surgical Wound Infection Colorectal Neoplasms Female Spain Postoperative Complications Humans Length of Stay Adult Aged, 80 and over Complicaciones Posoperatorias España Suplementos Dietéticos Adulto Cirugía Colorrectal Anciano de 80 o más Años Atención Perioperativa Anciano Estudios Prospectivos Protocolos Clínicos Persona de Mediana Edad Humanos Tiempo de Internación Masculino Femenino Infección de la Herida Quirúrgica Neoplasias Colorrectales
description	To compare immunonutrition versus standard high calorie nutrition in patients undergoing elective colorectal resection within an Enhanced Recovery After Surgery (ERAS) program.Despite progress in recent years in the surgical management of patients with colorectal cancer (ERAS programs), postoperative complications are frequent. Nutritional supplements enriched with immunonutrients have recently been introduced into clinical practice. However, the extent to which the combination of ERAS protocols and immunonutrition benefits patients undergoing colorectal cancer surgery is unknown.The SONVI study is a prospective, multicenter, randomized trial with 2 parallel treatment groups receiving either the study product (an immune-enhancing feed) or the control supplement (a hypercaloric hypernitrogenous supplement) for 7 days before colorectal resection and 5 days postoperatively.A total of 264 patients were randomized. At baseline, both groups were comparable in regards to age, sex, surgical risk, comorbidity, and analytical and nutritional parameters. The median length of the postoperative hospital stay was 5 days with no differences between the groups. A decrease in the total number of complications was observed in the immunonutrition group compared with the control group, primarily due to a significant decrease in infectious complications (23.8% vs. 10.7%, P=0.0007). Of the infectious complications, wound infection differed significantly between the groups (16.4% vs. 5.7%, P=0.0008). Other infectious complications were lower in the immunonutrition group but were not statistically significantly different.The implementation of ERAS protocols including immunonutrient-enriched supplements reduces the complications of patients undergoing colorectal resection.This study is registered with ClinicalTrial.gov: NCT02393976.
publishDate	2016
dc.date.none.fl_str_mv	2016 2016-05-01 2016 2016-05-01
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.13003/15251
url	https://hdl.handle.net/20.500.13003/15251
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Lippincott Williams & Wilkins
publisher.none.fl_str_mv	Lippincott Williams & Wilkins
dc.source.none.fl_str_mv	reponame:Docusalut instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str	Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str	Docusalut
collection	Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study)

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