Polyethylene Glycol 35 as a perfusate additive for mitochondrial and glycocalyx protection in HOPE liver preservation

Organ transplantation is a multifactorial process in which proper graft preservation is a mandatory step for the success of the transplantation. Hypothermic preservation of abdominal organs is mostly based on the use of several commercial solutions, including UW, Celsior, HTK and IGL-1. The presence...

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Autores: Panisello Roselló, Arnau, Teixeira da Silva, Rui, Castro Benítez, Carlos, Bardallo, Raquel G., Calvo Ademuz, Maria, Folch i Puy, Emma, Carbonell i Camós, Teresa, Palmeira, Carlos M., Roselló Catafau, Juan, Adam, R. (René)
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/170561
Acceso en línea:https://hdl.handle.net/2445/170561
Access Level:acceso abierto
Palabra clave:Trasplantament d'òrgans
Transplantation of organs
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spelling Polyethylene Glycol 35 as a perfusate additive for mitochondrial and glycocalyx protection in HOPE liver preservationPanisello Roselló, ArnauTeixeira da Silva, RuiCastro Benítez, CarlosBardallo, Raquel G.Calvo Ademuz, MariaFolch i Puy, EmmaCarbonell i Camós, TeresaPalmeira, Carlos M.Roselló Catafau, JuanAdam, R. (René)Trasplantament d'òrgansTransplantation of organsOrgan transplantation is a multifactorial process in which proper graft preservation is a mandatory step for the success of the transplantation. Hypothermic preservation of abdominal organs is mostly based on the use of several commercial solutions, including UW, Celsior, HTK and IGL-1. The presence of the oncotic agents HES (in UW) and PEG35 (in IGL-1) characterize both solution compositions, while HTK and Celsior do not contain any type of oncotic agent. Polyethylene glycols (PEGs) are non-immunogenic, non-toxic and water-soluble polymers, which present a combination of properties of particular interest in the clinical context of ischemia-reperfusion injury (IRI): they limit edema and nitric oxide induction and modulate immunogenicity. Besides static cold storage (SCS), there are other strategies to preserve the organ, such as the use of machine perfusion (MP) in dynamic preservation strategies, which increase graft function and survival as compared to the conventional static hypothermic preservation. Here we report some considerations about using PEG35 as a component of perfusates for MP strategies (such as hypothermic oxygenated perfusion, HOPE) and its benefits for liver graft preservation. Improved liver preservation is closely related to mitochondria integrity, making this organelle a good target to increase graft viability, especially in marginal organs (e.g., steatotic livers). The final goal is to increase the pool of suitable organs, and thereby shorten patient waiting lists, a crucial problem in liver transplantation.MDPI2020202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion16 p.application/pdfhttps://hdl.handle.net/2445/170561Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/ijms21165703International Journal of Molecular Sciences, 2020, vol. 21, num. 16, p. 5703https://doi.org/10.3390/ijms21165703info:eu-repo/grantAgreement/EC/H2020/722619cc-by (c) Panisello Rosello, Arnau et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1705612026-05-29T05:05:01Z
dc.title.none.fl_str_mv Polyethylene Glycol 35 as a perfusate additive for mitochondrial and glycocalyx protection in HOPE liver preservation
title Polyethylene Glycol 35 as a perfusate additive for mitochondrial and glycocalyx protection in HOPE liver preservation
spellingShingle Polyethylene Glycol 35 as a perfusate additive for mitochondrial and glycocalyx protection in HOPE liver preservation
Panisello Roselló, Arnau
Trasplantament d'òrgans
Transplantation of organs
title_short Polyethylene Glycol 35 as a perfusate additive for mitochondrial and glycocalyx protection in HOPE liver preservation
title_full Polyethylene Glycol 35 as a perfusate additive for mitochondrial and glycocalyx protection in HOPE liver preservation
title_fullStr Polyethylene Glycol 35 as a perfusate additive for mitochondrial and glycocalyx protection in HOPE liver preservation
title_full_unstemmed Polyethylene Glycol 35 as a perfusate additive for mitochondrial and glycocalyx protection in HOPE liver preservation
title_sort Polyethylene Glycol 35 as a perfusate additive for mitochondrial and glycocalyx protection in HOPE liver preservation
dc.creator.none.fl_str_mv Panisello Roselló, Arnau
Teixeira da Silva, Rui
Castro Benítez, Carlos
Bardallo, Raquel G.
Calvo Ademuz, Maria
Folch i Puy, Emma
Carbonell i Camós, Teresa
Palmeira, Carlos M.
Roselló Catafau, Juan
Adam, R. (René)
author Panisello Roselló, Arnau
author_facet Panisello Roselló, Arnau
Teixeira da Silva, Rui
Castro Benítez, Carlos
Bardallo, Raquel G.
Calvo Ademuz, Maria
Folch i Puy, Emma
Carbonell i Camós, Teresa
Palmeira, Carlos M.
Roselló Catafau, Juan
Adam, R. (René)
author_role author
author2 Teixeira da Silva, Rui
Castro Benítez, Carlos
Bardallo, Raquel G.
Calvo Ademuz, Maria
Folch i Puy, Emma
Carbonell i Camós, Teresa
Palmeira, Carlos M.
Roselló Catafau, Juan
Adam, R. (René)
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trasplantament d'òrgans
Transplantation of organs
topic Trasplantament d'òrgans
Transplantation of organs
description Organ transplantation is a multifactorial process in which proper graft preservation is a mandatory step for the success of the transplantation. Hypothermic preservation of abdominal organs is mostly based on the use of several commercial solutions, including UW, Celsior, HTK and IGL-1. The presence of the oncotic agents HES (in UW) and PEG35 (in IGL-1) characterize both solution compositions, while HTK and Celsior do not contain any type of oncotic agent. Polyethylene glycols (PEGs) are non-immunogenic, non-toxic and water-soluble polymers, which present a combination of properties of particular interest in the clinical context of ischemia-reperfusion injury (IRI): they limit edema and nitric oxide induction and modulate immunogenicity. Besides static cold storage (SCS), there are other strategies to preserve the organ, such as the use of machine perfusion (MP) in dynamic preservation strategies, which increase graft function and survival as compared to the conventional static hypothermic preservation. Here we report some considerations about using PEG35 as a component of perfusates for MP strategies (such as hypothermic oxygenated perfusion, HOPE) and its benefits for liver graft preservation. Improved liver preservation is closely related to mitochondria integrity, making this organelle a good target to increase graft viability, especially in marginal organs (e.g., steatotic livers). The final goal is to increase the pool of suitable organs, and thereby shorten patient waiting lists, a crucial problem in liver transplantation.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/170561
url https://hdl.handle.net/2445/170561
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms21165703
International Journal of Molecular Sciences, 2020, vol. 21, num. 16, p. 5703
https://doi.org/10.3390/ijms21165703
info:eu-repo/grantAgreement/EC/H2020/722619
dc.rights.none.fl_str_mv cc-by (c) Panisello Rosello, Arnau et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Panisello Rosello, Arnau et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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