Hepatocellular carcinoma risk-stratification based on ASGR1 in circulating epithelial cells for cancer interception

[Purpose] Lack of diagnostic and prognostic biomarkers in hepatocellular carcinoma impedes stratifying patients based on their risk of developing cancer. The aim of this study was to evaluate phenotypic and genetic heterogeneity of circulating epithelial cells (CECs) based on asialoglycoprotein rece...

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Detalles Bibliográficos
Autores: Roa-Colomo, Amparo, López-Garrido, Ángeles, Molina-Vallejo, Pilar, Rojas, Ángela, González-Sanchez, Mercedes, Aranda-García, Violeta, Salmerón, Javier, Romero Aguilar, Manuel, Muntané, Jordi, Padillo-Ruíz, Javier, Álamo-Martinez, José M., Lorente, José Antonio, Serrano, María José, Garrido-Navas, M. Carmen
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/306123
Acceso en línea:http://hdl.handle.net/10261/306123
https://api.elsevier.com/content/abstract/scopus_id/85143984811
Access Level:acceso abierto
Palabra clave:Cancer interception
Circulating tumor cells
Hepatocellular carcinoma
Liver cirrhosis
Precision medicine
Descripción
Sumario:[Purpose] Lack of diagnostic and prognostic biomarkers in hepatocellular carcinoma impedes stratifying patients based on their risk of developing cancer. The aim of this study was to evaluate phenotypic and genetic heterogeneity of circulating epithelial cells (CECs) based on asialoglycoprotein receptor 1 (ASGR1) and miR-122-5p expression as potential diagnostic and prognostic tools in patients with hepatocellular carcinoma (HCC) and liver cirrhosis (LC).

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