Reviewing Pseudoloma neurophilia infections in the popular zebrafish model

12 pages, 2 figures, 1 table.-- Data Availability Statement: Data openly available in a public repository that issues datasets with DOIs

Bibliographic Details
Authors: Caballero-Huertas, Marta, Soto, Manu, Ribas, Laia
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/250305
Online Access:http://hdl.handle.net/10261/250305
Access Level:Open access
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spelling Reviewing Pseudoloma neurophilia infections in the popular zebrafish modelCaballero-Huertas, MartaSoto, ManuRibas, Laia12 pages, 2 figures, 1 table.-- Data Availability Statement: Data openly available in a public repository that issues datasets with DOIsZebrafish is a worldwide used animal model to better understand cultured fish species; thus, in the last two decades, zebrafish facilities have been created in many aquaculture research centres. However, and despite the attempts of rigorous aseptic conditions for animal husbandry in wet laboratory facilities, the presence of parasites cannot be underestimated. The microsporidium Pseudoloma neurophilia, which mostly affects the central nervous system, has been listed as the most prevalent parasite in reared zebrafish. The emergence of P. neurophilia is usually detected when the individual presents irreversible morphological and/or behavioural symptoms, and consequently, the spread of the disease is inevitable, indicating that the infection is expanded across rearing tanks. This review attempts, for the first time, to collect and discuss the current information on P. neurophilia life cycle, target tissues and symptomatology of the infection occurred in zebrafish. Due to its vertical transmission together with the increasing presence of zebrafish as a model in reproduction-related problems found in aquaculture, it is highlighted, among others, the sexual dimorphism of the pathogenic effects and the possible transgenerational implications of parasitic infections. Further, to date none effective treatments have been described, so here we provide in detail available diagnostic methods, discussing the importance of the early detection, giving safety-rearing recommendations to decrease the presence of P. neurophilia. Our intention is to minimize parasite outbreaks in zebrafish facilities, which, on the one hand, can compromise zebrafish welfare, and on the other hand, could interfere furtively in the resulting research previously designed for improving aquaculture production but also other biomedical-related researchAuthors' research funding is supported by the Spanish Ministry of Science and Innovation grants AGL2015-73864-JIN ‘Ambisex’ and RYC2018-024017-I and by Spanish National Research Council (CSIC) grant 202030E004 ‘Interomics’ to LRWith the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S)Peer reviewedJohn Wiley & SonsMinisterio de Ciencia e Innovación (España)Ministerio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Ministerio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/250305reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-73864-JINinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RYC2018-024017-Ihttps://doi.org/10.1111/raq.12545Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2503052026-05-22T06:33:51Z
dc.title.none.fl_str_mv Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
title Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
spellingShingle Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
Caballero-Huertas, Marta
title_short Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
title_full Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
title_fullStr Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
title_full_unstemmed Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
title_sort Reviewing Pseudoloma neurophilia infections in the popular zebrafish model
dc.creator.none.fl_str_mv Caballero-Huertas, Marta
Soto, Manu
Ribas, Laia
author Caballero-Huertas, Marta
author_facet Caballero-Huertas, Marta
Soto, Manu
Ribas, Laia
author_role author
author2 Soto, Manu
Ribas, Laia
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description 12 pages, 2 figures, 1 table.-- Data Availability Statement: Data openly available in a public repository that issues datasets with DOIs
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/250305
url http://hdl.handle.net/10261/250305
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-73864-JIN
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RYC2018-024017-I
https://doi.org/10.1111/raq.12545
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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