Influence of impairment in renal function on the accuracy of high-sensitivity cardiac troponin T for the diagnosis of perioperative myocardial infarction after heart valve surgery

Producción Científica

Bibliographic Details
Authors: Cubero Gallego, Héctor, Heredia Rodríguez, María, Tamayo Gómez, Eduardo
Format: article
Status:Published version
Publication Date:2018
Country:España
Institution:Universidad de Valladolid
Repository:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/45726
Online Access:https://doi.org/10.1093/icvts/ivy066
http://uvadoc.uva.es/handle/10324/45726
Access Level:Open access
Keyword:Cardiac troponin T
Troponina T cardiaca
Renal dysfunction
Disfunción renal
Myocardial infarction
Infarto de miocardio
3213.07 Cirugía del Corazón
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spelling Influence of impairment in renal function on the accuracy of high-sensitivity cardiac troponin T for the diagnosis of perioperative myocardial infarction after heart valve surgeryCubero Gallego, HéctorHeredia Rodríguez, MaríaTamayo Gómez, EduardoCardiac troponin TTroponina T cardiacaRenal dysfunctionDisfunción renalMyocardial infarctionInfarto de miocardio3213.07 Cirugía del CorazónProducción CientíficaWe aimed to assess the influence of impairment in renal function over the high-sensitivity cardiac troponin T (hs-cTnT) accuracy to diagnose perioperative myocardial infarction (MI) after heart valve surgery. Heart valve surgery was performed in 805 patients from June 2012 to January 2016. Patients with enzymatic curves of hs-cTnT suggestive of myocardial necrosis and electrocardiogram and/or transthoracic echocardiogram criteria were identified as patients with perioperative MI. Impairment in renal function was defined as a postoperative creatinine clearance <50 ml/min at 16 h after surgery and for at least 48 h. Patients included were divided into 2 groups at 16 h: (i) patients with normal renal function (creatinine clearance >50 ml/min) and (ii) patients with impairment in renal function (creatinine clearance <50 ml/min). From a total of 805 patients undergoing heart valve surgery, 88 patients developed perioperative MI. When comparing receiver operating characteristic curves in patients with perioperative MI according to renal function, the optimal threshold of hs-cTnT at 16 h differed in patients with impairment in renal function (1303 vs 1095 pg/ml, P < 0.001). The diagnostic accuracy of hs-cTnT at 16 h was 93.4% [95% confidence interval (CI) 89.98–96.86], with an area under receiver operating characteristic curve (0.993, 95% CI 0.988–0.999 vs 0.972, 95% CI 0.952–0.992; P < 0.001). Renal function might influence in hs-cTnT levels. However, a hs-cTnT threshold of 1303 pg/ml at 16 h may be applied according to renal function to diagnose perioperative MI after cardiac surgery.Oxford University Press2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1093/icvts/ivy066http://uvadoc.uva.es/handle/10324/45726reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://academic.oup.com/icvts/article/27/2/234/4929834info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/457262026-06-13T12:44:47Z
dc.title.none.fl_str_mv Influence of impairment in renal function on the accuracy of high-sensitivity cardiac troponin T for the diagnosis of perioperative myocardial infarction after heart valve surgery
title Influence of impairment in renal function on the accuracy of high-sensitivity cardiac troponin T for the diagnosis of perioperative myocardial infarction after heart valve surgery
spellingShingle Influence of impairment in renal function on the accuracy of high-sensitivity cardiac troponin T for the diagnosis of perioperative myocardial infarction after heart valve surgery
Cubero Gallego, Héctor
Cardiac troponin T
Troponina T cardiaca
Renal dysfunction
Disfunción renal
Myocardial infarction
Infarto de miocardio
3213.07 Cirugía del Corazón
title_short Influence of impairment in renal function on the accuracy of high-sensitivity cardiac troponin T for the diagnosis of perioperative myocardial infarction after heart valve surgery
title_full Influence of impairment in renal function on the accuracy of high-sensitivity cardiac troponin T for the diagnosis of perioperative myocardial infarction after heart valve surgery
title_fullStr Influence of impairment in renal function on the accuracy of high-sensitivity cardiac troponin T for the diagnosis of perioperative myocardial infarction after heart valve surgery
title_full_unstemmed Influence of impairment in renal function on the accuracy of high-sensitivity cardiac troponin T for the diagnosis of perioperative myocardial infarction after heart valve surgery
title_sort Influence of impairment in renal function on the accuracy of high-sensitivity cardiac troponin T for the diagnosis of perioperative myocardial infarction after heart valve surgery
dc.creator.none.fl_str_mv Cubero Gallego, Héctor
Heredia Rodríguez, María
Tamayo Gómez, Eduardo
author Cubero Gallego, Héctor
author_facet Cubero Gallego, Héctor
Heredia Rodríguez, María
Tamayo Gómez, Eduardo
author_role author
author2 Heredia Rodríguez, María
Tamayo Gómez, Eduardo
author2_role author
author
dc.subject.none.fl_str_mv Cardiac troponin T
Troponina T cardiaca
Renal dysfunction
Disfunción renal
Myocardial infarction
Infarto de miocardio
3213.07 Cirugía del Corazón
topic Cardiac troponin T
Troponina T cardiaca
Renal dysfunction
Disfunción renal
Myocardial infarction
Infarto de miocardio
3213.07 Cirugía del Corazón
description Producción Científica
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1093/icvts/ivy066
http://uvadoc.uva.es/handle/10324/45726
url https://doi.org/10.1093/icvts/ivy066
http://uvadoc.uva.es/handle/10324/45726
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://academic.oup.com/icvts/article/27/2/234/4929834
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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