Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study

Background/Objectives: This study aimed to examine the association between leukocyte telomere length (TL) measured at ages 4 and 8 and emotional and behavioral problems at age 8. We also explored whether changes in leukocyte TL between ages 4 and 8 were associated with outcomes. Methods: Data were o...

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Autores: Campos Sánchez, Irene, Navarrete-Muñoz, Eva María, Barber-Valles, Josep Xavier, Martens, Dries, Riaño-Galan, Isolina, Irizar, Amaia, Llop, Sabrina, Guxens, Mònica, Rodríguez-Dehli, Ana Cristina, Babarro, Izaro, Lozano, Manuel, Vrijheid, Martine, Nawrot, Tim, Valera-Gran, Desirée
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/38984
Acceso en línea:https://hdl.handle.net/11000/38984
Access Level:acceso abierto
Palabra clave:telomere length
emotional problems
behavioral problems
internalizing problems
externalizing problems
childhood
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spelling Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) StudyCampos Sánchez, IreneNavarrete-Muñoz, Eva MaríaBarber-Valles, Josep XavierMartens, DriesRiaño-Galan, IsolinaIrizar, AmaiaLlop, SabrinaGuxens, MònicaRodríguez-Dehli, Ana CristinaBabarro, IzaroLozano, ManuelVrijheid, MartineNawrot, TimValera-Gran, Desiréetelomere lengthemotional problemsbehavioral problemsinternalizing problemsexternalizing problemschildhoodBackground/Objectives: This study aimed to examine the association between leukocyte telomere length (TL) measured at ages 4 and 8 and emotional and behavioral problems at age 8. We also explored whether changes in leukocyte TL between ages 4 and 8 were associated with outcomes. Methods: Data were obtained from a population-based birth cohort and included 647 children with TL at age 4 and emotional and behavioral assessments at age 8, 673 with TL and outcomes at age 8, and 315 with TL measured at both ages. TL was determined using quantitative PCR on blood samples and converted into z-scores for analysis. Emotional and behavioral problems-including internalizing, externalizing, and total difficulties-were assessed using the Strengths and Difficulties Questionnaire. Regression models were conducted using zero-inflated and negative binomial, adjusting for sociodemographic and lifestyle covariates. Results: No statistically significant associations were observed between leukocyte TL at ages 4 or 8, or TL changes over this period, and emotional and behavioral outcomes at age 8. Conclusions: Although no significant associations were found, further longitudinal research is warranted to clarify the role of TL as a potential psychobiomarker of emotional and behavioral disorders in childhood.MDPIDepartamentos de la UMH::Patología y Cirugía202620262025info:eu-repo/semantics/articleapplication/pdf14application/pdfhttps://hdl.handle.net/11000/38984reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheInglés10.3390/children12070875info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/389842026-05-27T13:36:21Z
dc.title.none.fl_str_mv Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study
title Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study
spellingShingle Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study
Campos Sánchez, Irene
telomere length
emotional problems
behavioral problems
internalizing problems
externalizing problems
childhood
title_short Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study
title_full Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study
title_fullStr Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study
title_full_unstemmed Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study
title_sort Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study
dc.creator.none.fl_str_mv Campos Sánchez, Irene
Navarrete-Muñoz, Eva María
Barber-Valles, Josep Xavier
Martens, Dries
Riaño-Galan, Isolina
Irizar, Amaia
Llop, Sabrina
Guxens, Mònica
Rodríguez-Dehli, Ana Cristina
Babarro, Izaro
Lozano, Manuel
Vrijheid, Martine
Nawrot, Tim
Valera-Gran, Desirée
author Campos Sánchez, Irene
author_facet Campos Sánchez, Irene
Navarrete-Muñoz, Eva María
Barber-Valles, Josep Xavier
Martens, Dries
Riaño-Galan, Isolina
Irizar, Amaia
Llop, Sabrina
Guxens, Mònica
Rodríguez-Dehli, Ana Cristina
Babarro, Izaro
Lozano, Manuel
Vrijheid, Martine
Nawrot, Tim
Valera-Gran, Desirée
author_role author
author2 Navarrete-Muñoz, Eva María
Barber-Valles, Josep Xavier
Martens, Dries
Riaño-Galan, Isolina
Irizar, Amaia
Llop, Sabrina
Guxens, Mònica
Rodríguez-Dehli, Ana Cristina
Babarro, Izaro
Lozano, Manuel
Vrijheid, Martine
Nawrot, Tim
Valera-Gran, Desirée
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Patología y Cirugía
dc.subject.none.fl_str_mv telomere length
emotional problems
behavioral problems
internalizing problems
externalizing problems
childhood
topic telomere length
emotional problems
behavioral problems
internalizing problems
externalizing problems
childhood
description Background/Objectives: This study aimed to examine the association between leukocyte telomere length (TL) measured at ages 4 and 8 and emotional and behavioral problems at age 8. We also explored whether changes in leukocyte TL between ages 4 and 8 were associated with outcomes. Methods: Data were obtained from a population-based birth cohort and included 647 children with TL at age 4 and emotional and behavioral assessments at age 8, 673 with TL and outcomes at age 8, and 315 with TL measured at both ages. TL was determined using quantitative PCR on blood samples and converted into z-scores for analysis. Emotional and behavioral problems-including internalizing, externalizing, and total difficulties-were assessed using the Strengths and Difficulties Questionnaire. Regression models were conducted using zero-inflated and negative binomial, adjusting for sociodemographic and lifestyle covariates. Results: No statistically significant associations were observed between leukocyte TL at ages 4 or 8, or TL changes over this period, and emotional and behavioral outcomes at age 8. Conclusions: Although no significant associations were found, further longitudinal research is warranted to clarify the role of TL as a potential psychobiomarker of emotional and behavioral disorders in childhood.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/38984
url https://hdl.handle.net/11000/38984
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 10.3390/children12070875
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
14
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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