Biosurfactant complexed with arginine has antibiofilm activity against methicillin-resistant Staphylococcus aureus

Aim: The present study investigated the antimicrobial effectiveness of a rhamnolipid complexed with arginine (RLMIX_Arg) against planktonic cells and biofilms of methicillin-resistant Staphylococcus aureus (MRSA). Methodology: Susceptibility testing was performed using the Clinical & Laboratory...

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Detalles Bibliográficos
Autores: Dias Barroso, Fatima Daiana, da Silva, Lisandra Juvêncio, Queiroz, Helaine Almeida, do Amaral Valente Sá, Lívia Gurgel, da Silva, Anderson Ramos, da Silva, Cecília Rocha, de Andrade Neto, João Batista, Cavalcanti, Bruno Coêlho, de Moraes, Manoel Odorico, Pinazo, Aurora, Pérez, Lourdes, Nobre Júnior, Hélio Vitoriano
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/382344
Acceso en línea:http://hdl.handle.net/10261/382344
https://api.elsevier.com/content/abstract/scopus_id/85195646358
Access Level:acceso abierto
Palabra clave:Surfactants
MRSA
Staphylococcus aureus
Biofilms
Medical catheter
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Descripción
Sumario:Aim: The present study investigated the antimicrobial effectiveness of a rhamnolipid complexed with arginine (RLMIX_Arg) against planktonic cells and biofilms of methicillin-resistant Staphylococcus aureus (MRSA). Methodology: Susceptibility testing was performed using the Clinical & Laboratory Standards Institute protocol: M07-A10, checkerboard test, biofilm in plates and catheters and flow cytometry were used. Result: RLMIX_Arg has bactericidal and synergistic activity with oxacillin. RLMIX_Arg inhibits the formation of MRSA biofilms on plates at sub-inhibitory concentrations and has antibiofilm action against MRSA in peripheral venous catheters. Catheters impregnated with RLMIX_Arg reduce the formation of MRSA biofilms. Conclusion: RLMIX_Arg exhibits potential for application in preventing infections related to methicillin-resistant S. aureus biofilms.

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