Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties

Metabolic Syndrome (MS) is related to increased risk of early death due to cardiovascular complications, among others. Dietary intervention has been suggested as the safest and most cost‐effective alternative for treatment of those alterations in patients with MS. The aim of this study was to invest...

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Autores: Garcés-Rimón, Marta, Cristina González, Raquel Hernanz, Esperanza Herradón, Angela Martín, Roberto Palacios, María Jesús Alonso, Uranga, Jose Antonio, López Miranda, Visitación, Miguel, Marta
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Rey Juan Carlos
Repositorio:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
OAI Identifier:oai:burjcdigital.urjc.es:10115/31884
Acceso en línea:https://hdl.handle.net/10115/31884
Access Level:acceso abierto
Palabra clave:cardiovascular diseases
egg white proteins
enzymatic hydrolysis
metabolic syndrome
Zucker rats
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spelling Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant propertiesGarcés-Rimón, MartaCristina GonzálezRaquel HernanzEsperanza HerradónAngela MartínRoberto PalaciosMaría Jesús AlonsoUranga, Jose AntonioLópez Miranda, VisitaciónMiguel, Martacardiovascular diseasesegg white proteinsenzymatic hydrolysismetabolic syndromeZucker ratsMetabolic Syndrome (MS) is related to increased risk of early death due to cardiovascular complications, among others. Dietary intervention has been suggested as the safest and most cost‐effective alternative for treatment of those alterations in patients with MS. The aim of this study was to investigate the effects of different egg white hydrolysates (HEW1 and HEW2) in obese Zucker rats, focus on the development of cardiovascular complications. Blood pressure, heart rate, basal cardiac function and vascular reactivity in aorta and mesenteric resistance arteries were evaluated. Reactive oxygen species production by dihydroethidium‐emitted fluorescence, NOX‐1 mRNA levels by qRT‐PCR, angiotensin‐converting enzyme activity by fluorimetry and kidney histopathology were also analysed. Both hydrolysates improve the endothelial dysfunction occurring in resistance arteries. Additionally, HEW2 reduced vascular oxidative stress. Practical applications Egg white is a good source of bioactive peptides, some of them with high antioxidant activity. They may be used as functional foods ingredients and could serve as an alternative therapeutic option to decrease some Metabolic Syndrome‐related complications. This study suggests that these hydrolysates could be an interesting nonpharmacological tool to control cardiovascular complications related to Metabolic Syndrome.Wiley Online Library202420242019info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10115/31884reponame:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlosinstname:Universidad Rey Juan CarlosInglésinfo:eu-repo/semantics/openAccessoai:burjcdigital.urjc.es:10115/318842026-06-24T12:48:17Z
dc.title.none.fl_str_mv Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties
title Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties
spellingShingle Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties
Garcés-Rimón, Marta
cardiovascular diseases
egg white proteins
enzymatic hydrolysis
metabolic syndrome
Zucker rats
title_short Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties
title_full Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties
title_fullStr Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties
title_full_unstemmed Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties
title_sort Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties
dc.creator.none.fl_str_mv Garcés-Rimón, Marta
Cristina González
Raquel Hernanz
Esperanza Herradón
Angela Martín
Roberto Palacios
María Jesús Alonso
Uranga, Jose Antonio
López Miranda, Visitación
Miguel, Marta
author Garcés-Rimón, Marta
author_facet Garcés-Rimón, Marta
Cristina González
Raquel Hernanz
Esperanza Herradón
Angela Martín
Roberto Palacios
María Jesús Alonso
Uranga, Jose Antonio
López Miranda, Visitación
Miguel, Marta
author_role author
author2 Cristina González
Raquel Hernanz
Esperanza Herradón
Angela Martín
Roberto Palacios
María Jesús Alonso
Uranga, Jose Antonio
López Miranda, Visitación
Miguel, Marta
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv cardiovascular diseases
egg white proteins
enzymatic hydrolysis
metabolic syndrome
Zucker rats
topic cardiovascular diseases
egg white proteins
enzymatic hydrolysis
metabolic syndrome
Zucker rats
description Metabolic Syndrome (MS) is related to increased risk of early death due to cardiovascular complications, among others. Dietary intervention has been suggested as the safest and most cost‐effective alternative for treatment of those alterations in patients with MS. The aim of this study was to investigate the effects of different egg white hydrolysates (HEW1 and HEW2) in obese Zucker rats, focus on the development of cardiovascular complications. Blood pressure, heart rate, basal cardiac function and vascular reactivity in aorta and mesenteric resistance arteries were evaluated. Reactive oxygen species production by dihydroethidium‐emitted fluorescence, NOX‐1 mRNA levels by qRT‐PCR, angiotensin‐converting enzyme activity by fluorimetry and kidney histopathology were also analysed. Both hydrolysates improve the endothelial dysfunction occurring in resistance arteries. Additionally, HEW2 reduced vascular oxidative stress. Practical applications Egg white is a good source of bioactive peptides, some of them with high antioxidant activity. They may be used as functional foods ingredients and could serve as an alternative therapeutic option to decrease some Metabolic Syndrome‐related complications. This study suggests that these hydrolysates could be an interesting nonpharmacological tool to control cardiovascular complications related to Metabolic Syndrome.
publishDate 2019
dc.date.none.fl_str_mv 2019
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10115/31884
url https://hdl.handle.net/10115/31884
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley Online Library
publisher.none.fl_str_mv Wiley Online Library
dc.source.none.fl_str_mv reponame:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
instname:Universidad Rey Juan Carlos
instname_str Universidad Rey Juan Carlos
reponame_str BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
collection BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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