Remyelination varies between and within lesions in multiple sclerosis following bexarotene

In multiple sclerosis chronic demyelination is associated with axonal loss, and ultimately contributes to irreversible progressive disability. Enhancing remyelination may slow, or even reverse, disability. We recently trialled bexarotene versus placebo in 49 people with multiple sclerosis. While the...

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Autores: Brown, William, Prados Carrasco, Ferran, Altmann, Daniel, Kanber, Baris, Stutters, Jonathan, Cunniffe, Nick, Jones, Joanne, Georgieva, Zoya, Needham, Edward, Daruwalla, Cyrus, Gandini Wheeler-Kingshott, Claudia A.M., Connick, Peter, Chandran, Siddharthan, Franklin, Robin, MacManus, David, Samson, Rebecca, Coles, Alasdair, Chard, Declan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universitat Oberta de Catalunya (UOC)
Repositorio:O2, repositorio institucional de la UOC
OAI Identifier:oai:openaccess.uoc.edu:10609/147057
Acceso en línea:https://hdl.handle.net/10609/147057
http://doi.org/10.1002/acn3.51662
Access Level:acceso abierto
Palabra clave:multiple sclerosis
esclerosi múltiple
esclerosis múltiple
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spelling Remyelination varies between and within lesions in multiple sclerosis following bexaroteneBrown, WilliamPrados Carrasco, FerranAltmann, DanielKanber, BarisStutters, JonathanCunniffe, NickJones, JoanneGeorgieva, ZoyaNeedham, EdwardDaruwalla, CyrusGandini Wheeler-Kingshott, Claudia A.M.Connick, PeterChandran, SiddharthanFranklin, RobinMacManus, DavidSamson, RebeccaColes, AlasdairChard, Declanmultiple sclerosisesclerosi múltipleesclerosis múltipleIn multiple sclerosis chronic demyelination is associated with axonal loss, and ultimately contributes to irreversible progressive disability. Enhancing remyelination may slow, or even reverse, disability. We recently trialled bexarotene versus placebo in 49 people with multiple sclerosis. While the primary MRI outcome was negative, there was converging neurophysiological and MRI evidence of efficacy. Multiple factors influence lesion remyelination. In this study we undertook a systematic exploratory analysis to determine whether treatment response – measured by change in magnetisation transfer ratio – is influenced by location (tissue type and proximity to CSF) or the degree of abnormality (using baseline magnetisation transfer ratio and T1 values).WileyUniversity of CambridgeUniversity College London (UCL)University of MelbourneUniversitat Oberta de Catalunya (UOC)London School of Hygiene and Tropical MedicineUniversity of PaviaUniversity of Edinburgh202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10609/147057http://doi.org/10.1002/acn3.51662reponame:O2, repositorio institucional de la UOCinstname:Universitat Oberta de Catalunya (UOC)InglésAnnals of Clinical and Translational Neurology, 2022, 10 (9)Annals of Clinical and Translational Neurology, 2022, 10 (9)https://onlinelibrary.wiley.com/doi/10.1002/acn3.51662CC BY 4.0https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:openaccess.uoc.edu:10609/1470572026-05-28T12:42:01Z
dc.title.none.fl_str_mv Remyelination varies between and within lesions in multiple sclerosis following bexarotene
title Remyelination varies between and within lesions in multiple sclerosis following bexarotene
spellingShingle Remyelination varies between and within lesions in multiple sclerosis following bexarotene
Brown, William
multiple sclerosis
esclerosi múltiple
esclerosis múltiple
title_short Remyelination varies between and within lesions in multiple sclerosis following bexarotene
title_full Remyelination varies between and within lesions in multiple sclerosis following bexarotene
title_fullStr Remyelination varies between and within lesions in multiple sclerosis following bexarotene
title_full_unstemmed Remyelination varies between and within lesions in multiple sclerosis following bexarotene
title_sort Remyelination varies between and within lesions in multiple sclerosis following bexarotene
dc.creator.none.fl_str_mv Brown, William
Prados Carrasco, Ferran
Altmann, Daniel
Kanber, Baris
Stutters, Jonathan
Cunniffe, Nick
Jones, Joanne
Georgieva, Zoya
Needham, Edward
Daruwalla, Cyrus
Gandini Wheeler-Kingshott, Claudia A.M.
Connick, Peter
Chandran, Siddharthan
Franklin, Robin
MacManus, David
Samson, Rebecca
Coles, Alasdair
Chard, Declan
author Brown, William
author_facet Brown, William
Prados Carrasco, Ferran
Altmann, Daniel
Kanber, Baris
Stutters, Jonathan
Cunniffe, Nick
Jones, Joanne
Georgieva, Zoya
Needham, Edward
Daruwalla, Cyrus
Gandini Wheeler-Kingshott, Claudia A.M.
Connick, Peter
Chandran, Siddharthan
Franklin, Robin
MacManus, David
Samson, Rebecca
Coles, Alasdair
Chard, Declan
author_role author
author2 Prados Carrasco, Ferran
Altmann, Daniel
Kanber, Baris
Stutters, Jonathan
Cunniffe, Nick
Jones, Joanne
Georgieva, Zoya
Needham, Edward
Daruwalla, Cyrus
Gandini Wheeler-Kingshott, Claudia A.M.
Connick, Peter
Chandran, Siddharthan
Franklin, Robin
MacManus, David
Samson, Rebecca
Coles, Alasdair
Chard, Declan
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv University of Cambridge
University College London (UCL)
University of Melbourne
Universitat Oberta de Catalunya (UOC)
London School of Hygiene and Tropical Medicine
University of Pavia
University of Edinburgh
dc.subject.none.fl_str_mv multiple sclerosis
esclerosi múltiple
esclerosis múltiple
topic multiple sclerosis
esclerosi múltiple
esclerosis múltiple
description In multiple sclerosis chronic demyelination is associated with axonal loss, and ultimately contributes to irreversible progressive disability. Enhancing remyelination may slow, or even reverse, disability. We recently trialled bexarotene versus placebo in 49 people with multiple sclerosis. While the primary MRI outcome was negative, there was converging neurophysiological and MRI evidence of efficacy. Multiple factors influence lesion remyelination. In this study we undertook a systematic exploratory analysis to determine whether treatment response – measured by change in magnetisation transfer ratio – is influenced by location (tissue type and proximity to CSF) or the degree of abnormality (using baseline magnetisation transfer ratio and T1 values).
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10609/147057
http://doi.org/10.1002/acn3.51662
url https://hdl.handle.net/10609/147057
http://doi.org/10.1002/acn3.51662
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Annals of Clinical and Translational Neurology, 2022, 10 (9)
Annals of Clinical and Translational Neurology, 2022, 10 (9)
https://onlinelibrary.wiley.com/doi/10.1002/acn3.51662
dc.rights.none.fl_str_mv CC BY 4.0
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC BY 4.0
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:O2, repositorio institucional de la UOC
instname:Universitat Oberta de Catalunya (UOC)
instname_str Universitat Oberta de Catalunya (UOC)
reponame_str O2, repositorio institucional de la UOC
collection O2, repositorio institucional de la UOC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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