Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort
Objectives: We aimed to assess the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and factors associated with seropositivity and asymptomatic coronavirus disease 2019 (COVID-19) among people with HIV (PWH). Methods: This was a cross-sectional study carried out within the...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/181864 |
| Acceso en línea: | https://hdl.handle.net/2445/181864 |
| Access Level: | acceso abierto |
| Palabra clave: | SARS-CoV-2 COVID-19 VIH (Virus) Serodiagnòstic HIV (Viruses) Serodiagnosis |
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Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network CohortBerenguer, JuanDíez, CristinaMartín Vicente, MaríaMicán, RafaelPérez Elías, María JesúsGarcía Fraile Fraile, Lucio JesúsVidal, FranciscoSuárez García, InésPodzamczer Palter, DanielRomero, Jorge delPulido, FedericoIribarren, José A.Gutiérrez, FélixPoveda, EvaGalera, CarlosIzquierdo, RebecaAsensi, VictorPortilla, JoaquínLópez, Juan C.Arribas, José RamónMoreno, SantiagoGonzález García, JuanResino, SalvadorJarrín, InmaculadaSARS-CoV-2COVID-19VIH (Virus)SerodiagnòsticSARS-CoV-2COVID-19HIV (Viruses)SerodiagnosisObjectives: We aimed to assess the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and factors associated with seropositivity and asymptomatic coronavirus disease 2019 (COVID-19) among people with HIV (PWH). Methods: This was a cross-sectional study carried out within the cohort of the Spanish HIV Research Network. Participants were consecutive PWH with plasma collected from 1st April to 30th September 2020. We determined SARS-CoV-2 antibodies (Abs) in plasma. Illness severity (NIH criteria) was assessed by a review of medical records and, if needed, participant interviews. Multivariable logistic regression analysis was used to identify predictors of seropositivity among the following variables: sex, age, country of birth, education level, comorbidities (hypertension, chronic heart disease, diabetes mellitus, non-AIDS-related cancer, chronic kidney disease, cirrhosis), route of HIV acquisition, prior AIDS, CD4+ cell count, HIV viral load, nucleoside/nucleotide reverse transcriptase inhibitor (N [t]RTI) backbone, type of third antiretroviral drug, and month of sample collection. Results: Of 1076 PWH (88.0% males, median age 43 years, 97.7% on antiretroviral therapy, median CD4+ 688 cells/mm3, 91.4% undetectable HIV viral load), SARS-CoV-2 Abs were detected in 91 PWH, a seroprevalence of 8.5% (95%CI 6.9-10.3%). Forty-five infections (45.0%) were asymptomatic. Variables independently associated with SARS-CoV-2 seropositivity were birth in Latin American countries versus Spain (adjusted odds ratio (aOR) 2.30, 95%CI 1.41-3.76, p 0.001), and therapy with tenofovir disoproxil fumarate plus emtricitabine (TDF/FTC) versus tenofovir alafenamide (TAF)/FTC as the N(t)RTI backbone (aOR 0.49, 95%CI 0.26-0.94, p 0.031). Conclusions: Many SARS-CoV-2 infections among PWH were asymptomatic, and birth in Latin American countries increased the risk of SARS-CoV-2 seropositivity. Our analysis, adjusted by comorbidities and other variables, suggests that TDF/FTC may prevent SARS-CoV-2 infection among PWH.Elsevier BV2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/181864Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.cmi.2021.06.023Clinical Microbiology and Infection, 2021, vol. 27, núm. 11, p. 1678-1684https://doi.org/10.1016/j.cmi.2021.06.023cc by-nc-nd (c) Berenguer, Juan et al., 2021http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1818642026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort |
| title |
Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort |
| spellingShingle |
Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort Berenguer, Juan SARS-CoV-2 COVID-19 VIH (Virus) Serodiagnòstic SARS-CoV-2 COVID-19 HIV (Viruses) Serodiagnosis |
| title_short |
Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort |
| title_full |
Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort |
| title_fullStr |
Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort |
| title_full_unstemmed |
Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort |
| title_sort |
Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort |
| dc.creator.none.fl_str_mv |
Berenguer, Juan Díez, Cristina Martín Vicente, María Micán, Rafael Pérez Elías, María Jesús García Fraile Fraile, Lucio Jesús Vidal, Francisco Suárez García, Inés Podzamczer Palter, Daniel Romero, Jorge del Pulido, Federico Iribarren, José A. Gutiérrez, Félix Poveda, Eva Galera, Carlos Izquierdo, Rebeca Asensi, Victor Portilla, Joaquín López, Juan C. Arribas, José Ramón Moreno, Santiago González García, Juan Resino, Salvador Jarrín, Inmaculada |
| author |
Berenguer, Juan |
| author_facet |
Berenguer, Juan Díez, Cristina Martín Vicente, María Micán, Rafael Pérez Elías, María Jesús García Fraile Fraile, Lucio Jesús Vidal, Francisco Suárez García, Inés Podzamczer Palter, Daniel Romero, Jorge del Pulido, Federico Iribarren, José A. Gutiérrez, Félix Poveda, Eva Galera, Carlos Izquierdo, Rebeca Asensi, Victor Portilla, Joaquín López, Juan C. Arribas, José Ramón Moreno, Santiago González García, Juan Resino, Salvador Jarrín, Inmaculada |
| author_role |
author |
| author2 |
Díez, Cristina Martín Vicente, María Micán, Rafael Pérez Elías, María Jesús García Fraile Fraile, Lucio Jesús Vidal, Francisco Suárez García, Inés Podzamczer Palter, Daniel Romero, Jorge del Pulido, Federico Iribarren, José A. Gutiérrez, Félix Poveda, Eva Galera, Carlos Izquierdo, Rebeca Asensi, Victor Portilla, Joaquín López, Juan C. Arribas, José Ramón Moreno, Santiago González García, Juan Resino, Salvador Jarrín, Inmaculada |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
SARS-CoV-2 COVID-19 VIH (Virus) Serodiagnòstic SARS-CoV-2 COVID-19 HIV (Viruses) Serodiagnosis |
| topic |
SARS-CoV-2 COVID-19 VIH (Virus) Serodiagnòstic SARS-CoV-2 COVID-19 HIV (Viruses) Serodiagnosis |
| description |
Objectives: We aimed to assess the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and factors associated with seropositivity and asymptomatic coronavirus disease 2019 (COVID-19) among people with HIV (PWH). Methods: This was a cross-sectional study carried out within the cohort of the Spanish HIV Research Network. Participants were consecutive PWH with plasma collected from 1st April to 30th September 2020. We determined SARS-CoV-2 antibodies (Abs) in plasma. Illness severity (NIH criteria) was assessed by a review of medical records and, if needed, participant interviews. Multivariable logistic regression analysis was used to identify predictors of seropositivity among the following variables: sex, age, country of birth, education level, comorbidities (hypertension, chronic heart disease, diabetes mellitus, non-AIDS-related cancer, chronic kidney disease, cirrhosis), route of HIV acquisition, prior AIDS, CD4+ cell count, HIV viral load, nucleoside/nucleotide reverse transcriptase inhibitor (N [t]RTI) backbone, type of third antiretroviral drug, and month of sample collection. Results: Of 1076 PWH (88.0% males, median age 43 years, 97.7% on antiretroviral therapy, median CD4+ 688 cells/mm3, 91.4% undetectable HIV viral load), SARS-CoV-2 Abs were detected in 91 PWH, a seroprevalence of 8.5% (95%CI 6.9-10.3%). Forty-five infections (45.0%) were asymptomatic. Variables independently associated with SARS-CoV-2 seropositivity were birth in Latin American countries versus Spain (adjusted odds ratio (aOR) 2.30, 95%CI 1.41-3.76, p 0.001), and therapy with tenofovir disoproxil fumarate plus emtricitabine (TDF/FTC) versus tenofovir alafenamide (TAF)/FTC as the N(t)RTI backbone (aOR 0.49, 95%CI 0.26-0.94, p 0.031). Conclusions: Many SARS-CoV-2 infections among PWH were asymptomatic, and birth in Latin American countries increased the risk of SARS-CoV-2 seropositivity. Our analysis, adjusted by comorbidities and other variables, suggests that TDF/FTC may prevent SARS-CoV-2 infection among PWH. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021 2021 2021 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/181864 |
| url |
https://hdl.handle.net/2445/181864 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1016/j.cmi.2021.06.023 Clinical Microbiology and Infection, 2021, vol. 27, núm. 11, p. 1678-1684 https://doi.org/10.1016/j.cmi.2021.06.023 |
| dc.rights.none.fl_str_mv |
cc by-nc-nd (c) Berenguer, Juan et al., 2021 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess |
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cc by-nc-nd (c) Berenguer, Juan et al., 2021 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
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openAccess |
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7 p. application/pdf |
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Elsevier BV |
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Elsevier BV |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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