Tailoring the self-assembly of a tripeptide for the formation of antimicrobial surfaces
The accumulation of bacteria on surfaces is currently one of the greatest concerns f or the supply of proper health, water and energy. Here, we describe the mechanism by which a single peptide forms two pH-dependent supramolecular particles that resist bacterial contamination. By using NMR and molec...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/172264 |
| Acceso en línea: | https://hdl.handle.net/2117/172264 https://dx.doi.org/10.1039/c8nr10043h |
| Access Level: | acceso abierto |
| Palabra clave: | Bacteria Peptides Molecular dynamics Surfaces (Technology) Nanotechnology Bacteris Pèptids Dinàmica molecular Superfícies (Tecnologia) Nanotecnologia Àrees temàtiques de la UPC::Enginyeria biomèdica |
| Sumario: | The accumulation of bacteria on surfaces is currently one of the greatest concerns f or the supply of proper health, water and energy. Here, we describe the mechanism by which a single peptide forms two pH-dependent supramolecular particles that resist bacterial contamination. By using NMR and molecular dynamics ( MD), we determined the structures of the peptide monomers and showed the forces directing the self-assembly of each structure under different conditions. These peptide assemblies change the characteristics of bare gla s and confer it with the ability to prevent biofilm formation. Furthermore, they can adsorb and re ease active compounds as demonstrated with an anticancer drug, antibiotic and enzyme. This synergism and the detailed understanding of the proces ses are necessary for developing new sterile surfaces for health-care systems, water puri ication devices, food packaging or any environment that suffers from biocontamination. |
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