Natural products, PGC-1 alpha, and Duchenne muscular dystrophy

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a transcriptional coactivator that binds to a diverse range of transcription factors. PPAR gamma coactivator 1 (PGC-1) coactivators possess an extensive range of biological effects in different tissues, and play a key part in the regul...

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Autores: Suntar, Ipek, Soldevila Verdeguer, Carla, Belwal, Tarun, Sanches Silva, Ana, Vacca, Rosa Anna, Tewari, Devesh, Sobarzo-Sanchez, Eduardo, Nabavi, Seyed Fazel, Shirooie, Samira, Dehpour, Ahmad Reza, Xu, Suowen, Yousefi, Bahman, Majidinia, Maryam, Daglia, Maria, D'Antona, Giuseppe, Nabavi, Seyed Mohammad
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/17243
Acceso en línea:https://hdl.handle.net/20.500.13003/17243
Access Level:acceso abierto
Palabra clave:Muscular dystrophy
Natural product
Peroxisome proliferatoractivated receptor gamma coactivator 1 alpha
PPAR gamma activation
Reactive oxygen species
Mitochondrial oxidative phosphorylation
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spelling Natural products, PGC-1 alpha, and Duchenne muscular dystrophySuntar, IpekSoldevila Verdeguer, CarlaBelwal, TarunSanches Silva, AnaVacca, Rosa AnnaTewari, DeveshSobarzo-Sanchez, EduardoNabavi, Seyed FazelShirooie, SamiraDehpour, Ahmad RezaXu, SuowenYousefi, BahmanMajidinia, MaryamDaglia, MariaD'Antona, GiuseppeNabavi, Seyed MohammadMuscular dystrophyNatural productPeroxisome proliferatoractivated receptor gamma coactivator 1 alphaPPAR gamma activationReactive oxygen speciesMitochondrial oxidative phosphorylationPeroxisome proliferator-activated receptor gamma (PPAR gamma) is a transcriptional coactivator that binds to a diverse range of transcription factors. PPAR gamma coactivator 1 (PGC-1) coactivators possess an extensive range of biological effects in different tissues, and play a key part in the regulation of the oxidative metabolism, consequently modulating the production of reactive oxygen species, autophagy, and mitochondrial biogenesis. Owing to these findings, a large body of studies, aiming to establish the role of PGC-1 in the neuromuscular system, has shown that PGC-1 could be a promising target for therapies targeting neuromuscular diseases. Among these, some evidence has shown that various signaling pathways linked to PGC-1 alpha are deregulated in muscular dystrophy, leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species (ROS) production. In the light of these results, any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular dystrophies. PGC-1 alpha is influenced by different patho-physiological/pharmacological stimuli. Natural products have been reported to display modulatory effects on PPAR gamma activation with fewer side effects in comparison to synthetic drugs. Taken together, this review summarizes the current knowledge on Duchenne muscular dystrophy, focusing on the potential effects of natural compounds, acting as regulators of PGC-1 alpha.Inst Materia Medica, Chinese Acad Medical Sciences20202020-05-0120202020-05-01review articlehttp://purl.org/coar/resource_type/c_dcae04bcinfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/17243reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/172432026-06-22T12:44:07Z
dc.title.none.fl_str_mv Natural products, PGC-1 alpha, and Duchenne muscular dystrophy
title Natural products, PGC-1 alpha, and Duchenne muscular dystrophy
spellingShingle Natural products, PGC-1 alpha, and Duchenne muscular dystrophy
Suntar, Ipek
Muscular dystrophy
Natural product
Peroxisome proliferatoractivated receptor gamma coactivator 1 alpha
PPAR gamma activation
Reactive oxygen species
Mitochondrial oxidative phosphorylation
title_short Natural products, PGC-1 alpha, and Duchenne muscular dystrophy
title_full Natural products, PGC-1 alpha, and Duchenne muscular dystrophy
title_fullStr Natural products, PGC-1 alpha, and Duchenne muscular dystrophy
title_full_unstemmed Natural products, PGC-1 alpha, and Duchenne muscular dystrophy
title_sort Natural products, PGC-1 alpha, and Duchenne muscular dystrophy
dc.creator.none.fl_str_mv Suntar, Ipek
Soldevila Verdeguer, Carla
Belwal, Tarun
Sanches Silva, Ana
Vacca, Rosa Anna
Tewari, Devesh
Sobarzo-Sanchez, Eduardo
Nabavi, Seyed Fazel
Shirooie, Samira
Dehpour, Ahmad Reza
Xu, Suowen
Yousefi, Bahman
Majidinia, Maryam
Daglia, Maria
D'Antona, Giuseppe
Nabavi, Seyed Mohammad
author Suntar, Ipek
author_facet Suntar, Ipek
Soldevila Verdeguer, Carla
Belwal, Tarun
Sanches Silva, Ana
Vacca, Rosa Anna
Tewari, Devesh
Sobarzo-Sanchez, Eduardo
Nabavi, Seyed Fazel
Shirooie, Samira
Dehpour, Ahmad Reza
Xu, Suowen
Yousefi, Bahman
Majidinia, Maryam
Daglia, Maria
D'Antona, Giuseppe
Nabavi, Seyed Mohammad
author_role author
author2 Soldevila Verdeguer, Carla
Belwal, Tarun
Sanches Silva, Ana
Vacca, Rosa Anna
Tewari, Devesh
Sobarzo-Sanchez, Eduardo
Nabavi, Seyed Fazel
Shirooie, Samira
Dehpour, Ahmad Reza
Xu, Suowen
Yousefi, Bahman
Majidinia, Maryam
Daglia, Maria
D'Antona, Giuseppe
Nabavi, Seyed Mohammad
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Muscular dystrophy
Natural product
Peroxisome proliferatoractivated receptor gamma coactivator 1 alpha

PPAR gamma activation
Reactive oxygen species
Mitochondrial oxidative phosphorylation
topic Muscular dystrophy
Natural product
Peroxisome proliferatoractivated receptor gamma coactivator 1 alpha
PPAR gamma activation
Reactive oxygen species
Mitochondrial oxidative phosphorylation
description Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a transcriptional coactivator that binds to a diverse range of transcription factors. PPAR gamma coactivator 1 (PGC-1) coactivators possess an extensive range of biological effects in different tissues, and play a key part in the regulation of the oxidative metabolism, consequently modulating the production of reactive oxygen species, autophagy, and mitochondrial biogenesis. Owing to these findings, a large body of studies, aiming to establish the role of PGC-1 in the neuromuscular system, has shown that PGC-1 could be a promising target for therapies targeting neuromuscular diseases. Among these, some evidence has shown that various signaling pathways linked to PGC-1 alpha are deregulated in muscular dystrophy, leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species (ROS) production. In the light of these results, any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular dystrophies. PGC-1 alpha is influenced by different patho-physiological/pharmacological stimuli. Natural products have been reported to display modulatory effects on PPAR gamma activation with fewer side effects in comparison to synthetic drugs. Taken together, this review summarizes the current knowledge on Duchenne muscular dystrophy, focusing on the potential effects of natural compounds, acting as regulators of PGC-1 alpha.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-05-01
2020
2020-05-01
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/17243
url https://hdl.handle.net/20.500.13003/17243
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Inst Materia Medica, Chinese Acad Medical Sciences
publisher.none.fl_str_mv Inst Materia Medica, Chinese Acad Medical Sciences
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408000042598400
score 15,811543

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