FISH analysis of hematological neoplasias with 1p36 rearrangements allows the definition of a cluster of 2.5 Mb included in the minimal region deleted in 1p36 deletion syndrome

Rearrangements in the distal region of the short arm of chromosome 1 are recurrent aberrations in a broad spectrum of human neoplasias. However, neither the location of the breakpoints (BP) on 1p36 nor the candidate genes have been fully determined. We have characterized, by fluorescence in situ hyb...

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Detalles Bibliográficos
Autores: Lahortiga, I. (Idoya)|||/items/bbdc8a60-fd2b-4f10-b51a-5b3e7a7897f7, Vazquez, I. (Iria)|||/items/302ec002-2422-4542-b373-6cc8b03418a4, Belloni, E. (E.)|||/items/02ddc7e9-287a-405d-a35f-68529086b931, Roman, J.P. (José P.)|||/items/63ee2210-9cad-4469-b4c6-694bba36caba, Gasparini, P. (P.)|||/items/a0e6c487-b45c-4cc4-af37-a5cbabe9f67b, Novo-Villaverde, F. J. (Francisco Javier)|||/items/703bb2c3-c163-4a9b-a218-5cb3837f1b84, Zudaire, I. (Isabel)|||/items/f15675dd-7003-44b2-89a0-bd4e3cae8551, Pelicci, P.G. (Pier G.)|||/items/25743caf-3173-4856-ae71-a4e6e2731ecc, Hernandez, J.M. (J. M.)|||/items/1355edb0-0024-4fb3-a667-9f0e8a4b6b31, Calasanz-Abinzano, M.J. (Maria Jose)|||/items/a1f10f5c-06ce-47eb-bfd8-91fb972d8086, Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251
Tipo de recurso: artículo
Fecha de publicación:2005
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/19455
Acceso en línea:https://hdl.handle.net/10171/19455
Access Level:acceso abierto
Palabra clave:Hematologic Neoplasms/genetics
Chromosome Aberrations
Chromosome Breakage
Chromosome Deletion
Chromosomes, Human, Pair 1
Descripción
Sumario:Rearrangements in the distal region of the short arm of chromosome 1 are recurrent aberrations in a broad spectrum of human neoplasias. However, neither the location of the breakpoints (BP) on 1p36 nor the candidate genes have been fully determined. We have characterized, by fluorescence in situ hybridization (FISH), the BP in 26 patients with hematological neoplasias and 1p36 rearrangements in the G-banding karyotype. FISH allowed a better characterization of all samples analyzed. Nine cases (35%) showed reciprocal translocations, 15 (58%) unbalanced rearrangements, and two (7%) deletions. We describe two new recurrent aberrations. In 18 of the 26 cases analyzed the BP were located in band 1p36, which is 25.5 Mb long. In 14 of these 18 cases (78%) and without distinction between myeloid and lymphoid neoplasias, the BP clustered in a 2.5 Mb region located between 1p36.32 and the telomere. Interestingly, this region is contained in the 10.5 Mb cluster on 1p36.22-1pter defined in cases with 1p36 deletion syndrome. The 2.5 Mb region, located on 1p36.32-1pter, has a higher frequency of occurrence of tandem repeats and segmental duplications larger than 1 kb, when compared with the 25.5 Mb of the complete 1p36 band. This could explain its proneness for involvement in chromosomal rearrangements in hematological neoplasias.

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