Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trial
Aim: To assess the effectiveness of two interventions of knowledge transfer and behavior modification to improve medication adherence in patients with depressive disorders. Methods: An open, multicenter, three-arm clinical trial with random allocation by cluster to usual care or to one of the two in...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad de La Laguna (ULL) |
| Repositorio: | RIULL. Repositorio Institucional de la Universidad de La Laguna |
| OAI Identifier: | oai:riull.ull.es:915/41091 |
| Acceso en línea: | http://riull.ull.es/xmlui/handle/915/41091 |
| Access Level: | acceso abierto |
| Palabra clave: | Depression Treatment adherence and compliance Antidepressive agents Spain Randomized controlled trial |
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Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trialPino-Sedeño, Tasmania delGonzález-Pacheco, HimarGonzález de León, BeatrizSerrano-Pérez, PedroAcosta Artiles, Francisco JavierValcarcel-Nazco, CristinaHurtado-Navarro, IsabelTrujillo-Martín, María M.Rodríguez Álvarez, CristobalinaDepressionTreatment adherence and complianceAntidepressive agentsSpainRandomized controlled trialAim: To assess the effectiveness of two interventions of knowledge transfer and behavior modification to improve medication adherence in patients with depressive disorders. Methods: An open, multicenter, three-arm clinical trial with random allocation by cluster to usual care or to one of the two interventions. The intervention for psychiatrists (PsI) included an educational program based on a patient-centered care model. The intervention for patients and relatives (PtI) included a collaborative care program plus a reminder system that works using an already available medication reminder application. The primary outcome was patient adherence to antidepressant treatment assessed through the Sidorkiewicz Adherence Instrument. Secondary measures were depression severity, comorbid anxiety and health-related quality of life. Mixed regression models with repeated measures were used for data analysis. Results: Ten psychiatrists and 150 patients diagnosed with depressive disorder from eight Community Mental Health Units in the Canary Islands (Spain) were included. Compared with usual care, no differences in long-term adherence were observed in either group PsI or PtI. The PsI group had significantly improved depression symptoms (B = −0.39; 95%CI: −0.65, −0.12; p = 0.004) during the follow-up period. The PtI group presented improved depression symptoms (B = −0.63; 95%CI: −0.96, −0.30; p < 0.001) and mental quality of life (B = 0.08; 95%CI: 0.004, 0.15; p = 0.039) during the follow-up period. Conclusion: The assessed interventions to improve adherence in patients with depressive disorder were effective for depression symptoms and mental quality of life, even over the long term. However, no effect on antidepressant adherence was observed.Obstetricia y Ginecología, Pediatría, Medicina Preventiva y Salud Pública, Toxicología y Medicina Legal y Forense y Parasitología202520252024info:eu-repo/semantics/articleapplication/pdfhttp://riull.ull.es/xmlui/handle/915/41091reponame:RIULL. Repositorio Institucional de la Universidad de La Lagunainstname:Universidad de La Laguna (ULL)InglésFrontiers in Public Health v.12, 2024Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ESoai:riull.ull.es:915/410912026-06-22T13:13:57Z |
| dc.title.none.fl_str_mv |
Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trial |
| title |
Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trial |
| spellingShingle |
Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trial Pino-Sedeño, Tasmania del Depression Treatment adherence and compliance Antidepressive agents Spain Randomized controlled trial |
| title_short |
Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trial |
| title_full |
Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trial |
| title_fullStr |
Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trial |
| title_full_unstemmed |
Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trial |
| title_sort |
Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trial |
| dc.creator.none.fl_str_mv |
Pino-Sedeño, Tasmania del González-Pacheco, Himar González de León, Beatriz Serrano-Pérez, Pedro Acosta Artiles, Francisco Javier Valcarcel-Nazco, Cristina Hurtado-Navarro, Isabel Trujillo-Martín, María M. Rodríguez Álvarez, Cristobalina |
| author |
Pino-Sedeño, Tasmania del |
| author_facet |
Pino-Sedeño, Tasmania del González-Pacheco, Himar González de León, Beatriz Serrano-Pérez, Pedro Acosta Artiles, Francisco Javier Valcarcel-Nazco, Cristina Hurtado-Navarro, Isabel Trujillo-Martín, María M. Rodríguez Álvarez, Cristobalina |
| author_role |
author |
| author2 |
González-Pacheco, Himar González de León, Beatriz Serrano-Pérez, Pedro Acosta Artiles, Francisco Javier Valcarcel-Nazco, Cristina Hurtado-Navarro, Isabel Trujillo-Martín, María M. Rodríguez Álvarez, Cristobalina |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Obstetricia y Ginecología, Pediatría, Medicina Preventiva y Salud Pública, Toxicología y Medicina Legal y Forense y Parasitología |
| dc.subject.none.fl_str_mv |
Depression Treatment adherence and compliance Antidepressive agents Spain Randomized controlled trial |
| topic |
Depression Treatment adherence and compliance Antidepressive agents Spain Randomized controlled trial |
| description |
Aim: To assess the effectiveness of two interventions of knowledge transfer and behavior modification to improve medication adherence in patients with depressive disorders. Methods: An open, multicenter, three-arm clinical trial with random allocation by cluster to usual care or to one of the two interventions. The intervention for psychiatrists (PsI) included an educational program based on a patient-centered care model. The intervention for patients and relatives (PtI) included a collaborative care program plus a reminder system that works using an already available medication reminder application. The primary outcome was patient adherence to antidepressant treatment assessed through the Sidorkiewicz Adherence Instrument. Secondary measures were depression severity, comorbid anxiety and health-related quality of life. Mixed regression models with repeated measures were used for data analysis. Results: Ten psychiatrists and 150 patients diagnosed with depressive disorder from eight Community Mental Health Units in the Canary Islands (Spain) were included. Compared with usual care, no differences in long-term adherence were observed in either group PsI or PtI. The PsI group had significantly improved depression symptoms (B = −0.39; 95%CI: −0.65, −0.12; p = 0.004) during the follow-up period. The PtI group presented improved depression symptoms (B = −0.63; 95%CI: −0.96, −0.30; p < 0.001) and mental quality of life (B = 0.08; 95%CI: 0.004, 0.15; p = 0.039) during the follow-up period. Conclusion: The assessed interventions to improve adherence in patients with depressive disorder were effective for depression symptoms and mental quality of life, even over the long term. However, no effect on antidepressant adherence was observed. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://riull.ull.es/xmlui/handle/915/41091 |
| url |
http://riull.ull.es/xmlui/handle/915/41091 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Frontiers in Public Health v.12, 2024 |
| dc.rights.none.fl_str_mv |
Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional) info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES |
| rights_invalid_str_mv |
Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional) https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES |
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openAccess |
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application/pdf |
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reponame:RIULL. Repositorio Institucional de la Universidad de La Laguna instname:Universidad de La Laguna (ULL) |
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Universidad de La Laguna (ULL) |
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RIULL. Repositorio Institucional de la Universidad de La Laguna |
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RIULL. Repositorio Institucional de la Universidad de La Laguna |
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