Role of Galectin-1 in pancreatic cancer stroma, a small but mischievous protein with a novel nuclear function
Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive tumors; mostly due to its lack of symptoms, resulting in late diagnosis, and also due to the presence of an aggressive tumor microenvironment. Importantly, Galectin-1 (Gal-1) exerts a crucial role in modulating tumor-stroma crossta...
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| Formato: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Recursos: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/666580 |
| Acesso em linha: | http://hdl.handle.net/10803/666580 |
| Access Level: | acceso abierto |
| Palavra-chave: | Pancreatic ductal anedocarcinoma Human pancreatic stellate cells Galectin-1 Stroma Extracellular matrix Càncer de pàncrees Cèl.lules estelades pancreàtiques humanes Galectina-1 Estroma Matriu extracel.lular 616.3 |
| Resumo: | Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive tumors; mostly due to its lack of symptoms, resulting in late diagnosis, and also due to the presence of an aggressive tumor microenvironment. Importantly, Galectin-1 (Gal-1) exerts a crucial role in modulating tumor-stroma crosstalk in this disease. In particular, our group has demonstrated that Gal-1 promotes tumor proliferation, metastasis, angiogenesis and immune evasion in PDA. This protein is mainly produced by PDA stellate cells (PSC), however the intrinsic role of this protein in PSC biology is poorly understood. In the present study, we determine the impact of Gal-1 in HPSC proliferation, migration, invasion, activation and extracellular matrix organization. Using high throughput analysis (microarrays) we have defined the molecular mechanisms underlying Gal-1 functions in HPSC. Finally, considering that Gal-1 is highly expressed in HPSC nuclei, we elucidate the involvement of nuclear Gal-1 in the regulation of gene expression in these cells. |
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