Use of nicergoline as adjunctive treatment of neurotrophic keratitis in routine clinical practice: a case series
Purpose: To describe the effectiveness and safety of nicergoline in patients with epithelial corneal defect or corneal ulcer due to neurotrophic keratitis. Methods: A prospective case series review was performed in 14 patients (14 eyes) with neurotrophic keratopathy who started treatment with nicerg...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/160157 |
| Acceso en línea: | https://hdl.handle.net/11441/160157 https://doi.org/10.1080/09273948.2021.1976214 |
| Access Level: | acceso abierto |
| Palabra clave: | Nicergoline Neurotrophic keratitis Persistent corneal epithelial defect Corneal ulcer |
| Sumario: | Purpose: To describe the effectiveness and safety of nicergoline in patients with epithelial corneal defect or corneal ulcer due to neurotrophic keratitis. Methods: A prospective case series review was performed in 14 patients (14 eyes) with neurotrophic keratopathy who started treatment with nicergoline as an off-label prescription from January to November of 2020. Patients with a epithelial defect or corneal ulcer due to neurotrophic keratitis were treated with 10 mg of oral nicergoline twice daily. Results/Serial cases: Complete corneal healing was observed in 10 (71.4%) of the 14 patients after 25.6 ± 26.60 days (range 7-90) with nicergoline. In three (21.5%) patients the wound healing was not achieved (all of them with autoimmune disease), and one patient (7.1%) was lost to follow-up. Eleven patients (79%) were females; the average age at consultation was 69 years (44-96). The mean time between diagnosis and the starting of nicergoline was 10.92 ± 8.85 days (0-28). No adverse effects of nicergoline were observed in any subject. Conclusion: Nicergoline as an adjunctive treatment for neurotrophic keratitis showed a potential use in the healing of epithelial defect with a good tolerance in real-life clinical practice. Introduction: |
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