Endothelial vascularization, HUVEC monolayer coating of a microchannel under flow conditions
Microfluidic devices have been studied and developed over the last decades due to their multiple biology applications. One of their fields of most interest is the organ-on-a-chip technology, which consists in emulating an organ on a microchip. This technology presents several advantages, from ethica...
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| Tipo de recurso: | tesis de maestría |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/403847 |
| Acceso en línea: | https://hdl.handle.net/2117/403847 |
| Access Level: | acceso embargado |
| Palabra clave: | Microfluidics Endothelines lab-on-a-chip endothelialization microchannels shear stress Microfluídica Endotelines Àrees temàtiques de la UPC::Física::Física de fluids |
| Sumario: | Microfluidic devices have been studied and developed over the last decades due to their multiple biology applications. One of their fields of most interest is the organ-on-a-chip technology, which consists in emulating an organ on a microchip. This technology presents several advantages, from ethical aspects for stop experimenting with animals to the control of many parameters while performing an experiment. This master?s thesis explores new microfluidic devices designs in order to study the malaria?s parasite \textit{Plasmodium vivax}, which is one of the main parasites that spread the disease. The parasite enters into the human body through the circulatory system, so the designs are focused on emulate blood vessels and the aim of this project is to search the best ways to ease the formation of a monolayer of endothelial cells over the walls of the channels of the microdevice under flow conditions. In concrete, the project studies the relation between the microdevices material PDMS and fluids as well as the interaction with microdevices walls when fluid is flowing through it in order to better the signs and achieve suitable parameters. |
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