Epigenetic regulation of gfi1 in endocrine-related cancers

Ashour, Nadia; Angulo, Javier C|||0000-0002-1735-8792; González-Corpas, Ana|||0000-0002-2644-756X; Orea, María Jesús; Lobo, M. V. T.|||0000-0001-7222-8096; Colomer, Ramon|||0000-0002-6393-3444; Colás Escudero, Begoña|||0000-0001-7913-3006; Esteller, M.|||0000-0003-4490-6093; Ropero, Santiago|||0000-0003-3522-8104

Epigenetic regulation of gfi1 in endocrine-related cancers

Prostate and breast cancer constitute the most common cancers among men and women worldwide. The aging population is one of the main risk factors for prostate and breast cancer development and accumulating studies link aging with epigenetic changes. Growth factor independence-1 (Gfi1) is a transcrip...

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Autores:	Ashour, Nadia, Angulo, Javier C\|\|\|0000-0002-1735-8792, González-Corpas, Ana\|\|\|0000-0002-2644-756X, Orea, María Jesús, Lobo, M. V. T.\|\|\|0000-0001-7222-8096, Colomer, Ramon\|\|\|0000-0002-6393-3444, Colás Escudero, Begoña\|\|\|0000-0001-7913-3006, Esteller, M.\|\|\|0000-0003-4490-6093, Ropero, Santiago\|\|\|0000-0003-3522-8104
Tipo de recurso:	artículo
Fecha de publicación:	2020
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:236624
Acceso en línea:	https://ddd.uab.cat/record/236624 https://dx.doi.org/urn:doi:10.3390/ijms21134687
Access Level:	acceso abierto
Palabra clave:	Prostate cancer Breast cancer Gfi1 DNA methylation

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spelling	Epigenetic regulation of gfi1 in endocrine-related cancersA role regulating tumor growthAshour, NadiaAngulo, Javier C\|\|\|0000-0002-1735-8792González-Corpas, Ana\|\|\|0000-0002-2644-756XOrea, María JesúsLobo, M. V. T.\|\|\|0000-0001-7222-8096Colomer, Ramon\|\|\|0000-0002-6393-3444Colás Escudero, Begoña\|\|\|0000-0001-7913-3006Esteller, M.\|\|\|0000-0003-4490-6093Ropero, Santiago\|\|\|0000-0003-3522-8104Prostate cancerBreast cancerGfi1DNA methylationProstate and breast cancer constitute the most common cancers among men and women worldwide. The aging population is one of the main risk factors for prostate and breast cancer development and accumulating studies link aging with epigenetic changes. Growth factor independence-1 (Gfi1) is a transcriptional repressor with an important role in human malignancies, including leukemia, colorectal carcinoma, and lung cancer, but its role in prostate and breast cancer is unknown. We have found that Gfi1 epigenetic silencing is a common event in prostate and breast cancer. Gfi1 re-expression in prostate and breast cancer cell lines displaying Gfi1 epigenetic silencing decreases cell proliferation, reduced colony formation density, and tumor growth in nude mice xenografts. In addition, we found that Gfi1 repress alpha 1-anti-trypsin (AAT) and alpha 1-anti-chymotrypsin (ACT) expression, two genes with important functions in cancer development, suggesting that Gfi1 silencing promotes tumor growth by increasing AAT and ACT expression in our system. Finally, Gfi1 epigenetic silencing could be a promising biomarker for prostate cancer progression because it is associated with shorter disease-free survival. In conclusion, our findings strongly indicate that Gfi1 epigenetic silencing in prostate and breast cancer could be a crucial step in the development of these two-well characterized endocrine related tumors.Universitat Autònoma de Barcelona 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/236624https://dx.doi.org/urn:doi:10.3390/ijms21134687reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI16-594Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI11-608open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2366242026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Epigenetic regulation of gfi1 in endocrine-related cancers A role regulating tumor growth
title	Epigenetic regulation of gfi1 in endocrine-related cancers
spellingShingle	Epigenetic regulation of gfi1 in endocrine-related cancers Ashour, Nadia Prostate cancer Breast cancer Gfi1 DNA methylation
title_short	Epigenetic regulation of gfi1 in endocrine-related cancers
title_full	Epigenetic regulation of gfi1 in endocrine-related cancers
title_fullStr	Epigenetic regulation of gfi1 in endocrine-related cancers
title_full_unstemmed	Epigenetic regulation of gfi1 in endocrine-related cancers
title_sort	Epigenetic regulation of gfi1 in endocrine-related cancers
dc.creator.none.fl_str_mv	Ashour, Nadia Angulo, Javier C\|\|\|0000-0002-1735-8792 González-Corpas, Ana\|\|\|0000-0002-2644-756X Orea, María Jesús Lobo, M. V. T.\|\|\|0000-0001-7222-8096 Colomer, Ramon\|\|\|0000-0002-6393-3444 Colás Escudero, Begoña\|\|\|0000-0001-7913-3006 Esteller, M.\|\|\|0000-0003-4490-6093 Ropero, Santiago\|\|\|0000-0003-3522-8104
author	Ashour, Nadia
author_facet	Ashour, Nadia Angulo, Javier C\|\|\|0000-0002-1735-8792 González-Corpas, Ana\|\|\|0000-0002-2644-756X Orea, María Jesús Lobo, M. V. T.\|\|\|0000-0001-7222-8096 Colomer, Ramon\|\|\|0000-0002-6393-3444 Colás Escudero, Begoña\|\|\|0000-0001-7913-3006 Esteller, M.\|\|\|0000-0003-4490-6093 Ropero, Santiago\|\|\|0000-0003-3522-8104
author_role	author
author2	Angulo, Javier C\|\|\|0000-0002-1735-8792 González-Corpas, Ana\|\|\|0000-0002-2644-756X Orea, María Jesús Lobo, M. V. T.\|\|\|0000-0001-7222-8096 Colomer, Ramon\|\|\|0000-0002-6393-3444 Colás Escudero, Begoña\|\|\|0000-0001-7913-3006 Esteller, M.\|\|\|0000-0003-4490-6093 Ropero, Santiago\|\|\|0000-0003-3522-8104
author2_role	author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv	Prostate cancer Breast cancer Gfi1 DNA methylation
topic	Prostate cancer Breast cancer Gfi1 DNA methylation
description	Prostate and breast cancer constitute the most common cancers among men and women worldwide. The aging population is one of the main risk factors for prostate and breast cancer development and accumulating studies link aging with epigenetic changes. Growth factor independence-1 (Gfi1) is a transcriptional repressor with an important role in human malignancies, including leukemia, colorectal carcinoma, and lung cancer, but its role in prostate and breast cancer is unknown. We have found that Gfi1 epigenetic silencing is a common event in prostate and breast cancer. Gfi1 re-expression in prostate and breast cancer cell lines displaying Gfi1 epigenetic silencing decreases cell proliferation, reduced colony formation density, and tumor growth in nude mice xenografts. In addition, we found that Gfi1 repress alpha 1-anti-trypsin (AAT) and alpha 1-anti-chymotrypsin (ACT) expression, two genes with important functions in cancer development, suggesting that Gfi1 silencing promotes tumor growth by increasing AAT and ACT expression in our system. Finally, Gfi1 epigenetic silencing could be a promising biomarker for prostate cancer progression because it is associated with shorter disease-free survival. In conclusion, our findings strongly indicate that Gfi1 epigenetic silencing in prostate and breast cancer could be a crucial step in the development of these two-well characterized endocrine related tumors.
publishDate	2020
dc.date.none.fl_str_mv	2 2020-01-01 2020 2020-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/236624 https://dx.doi.org/urn:doi:10.3390/ijms21134687
url	https://ddd.uab.cat/record/236624 https://dx.doi.org/urn:doi:10.3390/ijms21134687
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI16-594 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI11-608
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
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Epigenetic regulation of gfi1 in endocrine-related cancers

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