Oleanolic Acid: Extraction, Characterization and Biological Activity

29 Páginas.-- 1 Tabla.-- 4 Figuras

Detalles Bibliográficos
Autores: Castellano, José María, Ramos-Romero, Sara, Perona, Javier S.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/263657
Acceso en línea:http://hdl.handle.net/10261/263657
https://api.elsevier.com/content/abstract/scopus_id/85123638341
Access Level:acceso abierto
Palabra clave:Biological activities
Characterization
Diseases
Mechanisms
Oleanolic acid
Structure
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spelling Oleanolic Acid: Extraction, Characterization and Biological ActivityCastellano, José MaríaRamos-Romero, SaraPerona, Javier S.Biological activitiesCharacterizationDiseasesMechanismsOleanolic acidStructure29 Páginas.-- 1 Tabla.-- 4 FigurasOleanolic acid, a pentacyclic triterpenoid ubiquitously present in the plant kingdom, is receiving outstanding attention from the scientific community due to its biological activity against multiple diseases. Oleanolic acid is endowed with a wide range of biological activities with therapeutic potential by means of complex and multifactorial mechanisms. There is evidence suggesting that oleanolic acid might be effective against dyslipidemia, diabetes and metabolic syndrome, through enhancing insulin response, preserving the functionality and survival of β-cells and pro-tecting against diabetes complications. In addition, several other functions have been proposed, in-cluding antiviral, anti-HIV, antibacterial, antifungal, anticarcinogenic, anti-inflammatory, hepato-protective, gastroprotective, hypolipidemic and anti-atherosclerotic activities, as well as interfering in several stages of the development of different types of cancer; however, due to its hydrophobic nature, oleanolic acid is almost insoluble in water, which has led to a number of approaches to enhance its biopharmaceutical properties. In this scenario, the present review aimed to summarize the current knowledge and the research progress made in the last years on the extraction and characterization of oleanolic acid and its biological activities and the underlying mechanisms of action.This research was funded by the Spanish National Research Agency, grant number PID2019-107837RB-I00, AGL2017-83599-R, PID2020-117009RB-I00.Peer reviewedMultidisciplinary Digital Publishing InstituteAgencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/263657https://api.elsevier.com/content/abstract/scopus_id/85123638341reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107837RB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-83599-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117009RB-I00Nutrientshttp://dx.doi.org/10.3390/nu14030623Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2636572026-05-22T06:33:51Z
dc.title.none.fl_str_mv Oleanolic Acid: Extraction, Characterization and Biological Activity
title Oleanolic Acid: Extraction, Characterization and Biological Activity
spellingShingle Oleanolic Acid: Extraction, Characterization and Biological Activity
Castellano, José María
Biological activities
Characterization
Diseases
Mechanisms
Oleanolic acid
Structure
title_short Oleanolic Acid: Extraction, Characterization and Biological Activity
title_full Oleanolic Acid: Extraction, Characterization and Biological Activity
title_fullStr Oleanolic Acid: Extraction, Characterization and Biological Activity
title_full_unstemmed Oleanolic Acid: Extraction, Characterization and Biological Activity
title_sort Oleanolic Acid: Extraction, Characterization and Biological Activity
dc.creator.none.fl_str_mv Castellano, José María
Ramos-Romero, Sara
Perona, Javier S.
author Castellano, José María
author_facet Castellano, José María
Ramos-Romero, Sara
Perona, Javier S.
author_role author
author2 Ramos-Romero, Sara
Perona, Javier S.
author2_role author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Biological activities
Characterization
Diseases
Mechanisms
Oleanolic acid
Structure
topic Biological activities
Characterization
Diseases
Mechanisms
Oleanolic acid
Structure
description 29 Páginas.-- 1 Tabla.-- 4 Figuras
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/263657
https://api.elsevier.com/content/abstract/scopus_id/85123638341
url http://hdl.handle.net/10261/263657
https://api.elsevier.com/content/abstract/scopus_id/85123638341
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107837RB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-83599-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117009RB-I00
Nutrients
http://dx.doi.org/10.3390/nu14030623
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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