Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer

Advanced stage; Endometrial cancer; Outcome

Detalles Bibliográficos
Autores: Lombaers, Marike, Cornel, Karlijn M. C., Visser, Nicole, Bulten, Johan, Küsters-Vandevelde, Heidi V. N., Amant, Frédéric, Colás Ortega, Eva, Gil-Moreno, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/9575
Acceso en línea:https://hdl.handle.net/11351/9575
http://hdl.handle.net/11351/9575
Access Level:acceso abierto
Palabra clave:Endometri - Càncer
Marcadors tumorals
CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor
DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Female::Uterine Neoplasms::Endometrial Neoplasms
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales femeninos::neoplasias uterinas::neoplasias endometriales
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oai_identifier_str oai:recercat.cat:11351/9575
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
title Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
spellingShingle Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
Lombaers, Marike
Endometri - Càncer
Marcadors tumorals
CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor
DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Female::Uterine Neoplasms::Endometrial Neoplasms
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales femeninos::neoplasias uterinas::neoplasias endometriales
title_short Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
title_full Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
title_fullStr Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
title_full_unstemmed Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
title_sort Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
dc.creator.none.fl_str_mv Lombaers, Marike
Cornel, Karlijn M. C.
Visser, Nicole
Bulten, Johan
Küsters-Vandevelde, Heidi V. N.
Amant, Frédéric
Colás Ortega, Eva
Gil-Moreno, Antonio
author Lombaers, Marike
author_facet Lombaers, Marike
Cornel, Karlijn M. C.
Visser, Nicole
Bulten, Johan
Küsters-Vandevelde, Heidi V. N.
Amant, Frédéric
Colás Ortega, Eva
Gil-Moreno, Antonio
author_role author
author2 Cornel, Karlijn M. C.
Visser, Nicole
Bulten, Johan
Küsters-Vandevelde, Heidi V. N.
Amant, Frédéric
Colás Ortega, Eva
Gil-Moreno, Antonio
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Lombaers MS] Department of Obstetrics and Gynaecology, Radboud University Medical Center, GA Nijmegen, The Netherlands. Radboud Institute of Health Sciences, GA Nijmegen, The Netherlands. [Cornel KMC] Department of Obstetrics and Gynaecology, Radboud University Medical Center, GA Nijmegen, The Netherlands. Department of Obstetrics and Gynecology, Division Gynecologic Oncology, University of Toronto, Toronto, Canada. [Visser NCM] Department of Pathology, Eurofins PAMM, Eindhoven, The Netherlands. [Bulten J] Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands. [Küsters-Vandevelde HVN] Department of Pathology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands. [Amant F] Department of Oncology, KU Leuven, Leuven, Belgium. Center for Gynecologic Oncology Amsterdam, Netherlands Cancer Institute and Amsterdam University Medical Center, Amsterdam, The Netherlands. [Colas E] Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red Cáncer, Barcelona, Spain. [Gil-Moreno A] Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red Cáncer, Barcelona, Spain. Servei de Ginecologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red Cáncer, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Endometri - Càncer
Marcadors tumorals
CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor
DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Female::Uterine Neoplasms::Endometrial Neoplasms
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales femeninos::neoplasias uterinas::neoplasias endometriales
topic Endometri - Càncer
Marcadors tumorals
CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor
DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Female::Uterine Neoplasms::Endometrial Neoplasms
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales femeninos::neoplasias uterinas::neoplasias endometriales
description Advanced stage; Endometrial cancer; Outcome
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/9575
http://hdl.handle.net/11351/9575
url https://hdl.handle.net/11351/9575
http://hdl.handle.net/11351/9575
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cancers;15(9)
https://doi.org/10.3390/cancers15092605
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial CancerLombaers, MarikeCornel, Karlijn M. C.Visser, NicoleBulten, JohanKüsters-Vandevelde, Heidi V. N.Amant, FrédéricColás Ortega, EvaGil-Moreno, AntonioEndometri - CàncerMarcadors tumoralsCHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, TumorDISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Female::Uterine Neoplasms::Endometrial NeoplasmsCOMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumoralesENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales femeninos::neoplasias uterinas::neoplasias endometrialesAdvanced stage; Endometrial cancer; OutcomeEtapa avançada; Càncer d'endometri; ResultatEtapa avanzada; Cáncer de endometrio; ResultadoPatients with high-grade endometrial carcinoma (EC) have an increased risk of tumor spread and lymph node metastasis (LNM). Preoperative imaging and CA125 can be used in work-up. As data on cancer antigen 125 (CA125) in high-grade EC are limited, we aimed to study primarily the predictive value of CA125, and secondarily the contributive value of computed tomography (CT) for advanced stage and LNM. Patients with high-grade EC (n = 333) and available preoperative CA125 were included retrospectively. The association of CA125 and CT findings with LNM was analyzed by logistic regression. Elevated CA125 ((>35 U/mL), (35.2% (68/193)) was significantly associated with stage III-IV disease (60.3% (41/68)) compared with normal CA125 (20.8% (26/125), [p < 0.001]), and with reduced disease-specific—(DSS) (p < 0.001) and overall survival (OS) (p < 0.001). The overall accuracy of predicting LNM by CT resulted in an area under the curve (AUC) of 0.623 (p < 0.001) independent of CA125. Stratification by CA125 resulted in an AUC of 0.484 (normal), and 0.660 (elevated). In multivariate analysis elevated CA125, non-endometrioid histology, pathological deep myometrial invasion ≥50%, and cervical involvement were significant predictors of LNM, whereas suspected LNM on CT was not. This shows that elevated CA125 is a relevant independent predictor of advanced stage and outcome specifically in high-grade EC.MDPIInstitut Català de la Salut[Lombaers MS] Department of Obstetrics and Gynaecology, Radboud University Medical Center, GA Nijmegen, The Netherlands. Radboud Institute of Health Sciences, GA Nijmegen, The Netherlands. [Cornel KMC] Department of Obstetrics and Gynaecology, Radboud University Medical Center, GA Nijmegen, The Netherlands. Department of Obstetrics and Gynecology, Division Gynecologic Oncology, University of Toronto, Toronto, Canada. [Visser NCM] Department of Pathology, Eurofins PAMM, Eindhoven, The Netherlands. [Bulten J] Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands. [Küsters-Vandevelde HVN] Department of Pathology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands. [Amant F] Department of Oncology, KU Leuven, Leuven, Belgium. Center for Gynecologic Oncology Amsterdam, Netherlands Cancer Institute and Amsterdam University Medical Center, Amsterdam, The Netherlands. [Colas E] Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red Cáncer, Barcelona, Spain. [Gil-Moreno A] Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red Cáncer, Barcelona, Spain. Servei de Ginecologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red Cáncer, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/9575http://hdl.handle.net/11351/9575Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCancers;15(9)https://doi.org/10.3390/cancers15092605Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/95752026-05-29T05:05:01Z
score 15,81155

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