The prevalence of narcolepsy in Catalunya (Spain).

Previous studies have estimated an overall prevalence for narcolepsy between 15 and 70 cases per 100 000 inhabitants. We aimed to estimate the prevalence of narcolepsy in Catalunya (Catalonia), a north-east region of Spain (7 424 754 inhabitants), on 31 December 2014 by identifying all living subjec...

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Autores: Tió E, Gaig C, Giner-Soriano M, Romero O, Jurado MJ, Sansa G, Pujol M, Sans O, Álvarez-Guerrico I, Caballol N, Jimenez M, Becerra JL, Escartin A, Monasterio C, Molins A, Bove A, Viña J, Iranzo A, Cambrodi R, Calvo G, Morros R, Santamaria J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:dnet:r-fsjd______::bcc1b8e361e088a767fca135e59abe5e
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13243
Access Level:acceso abierto
Palabra clave:*cataplexy
*epidemiology
*narcolepsy type 1
*narcolepsy type 2
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spelling The prevalence of narcolepsy in Catalunya (Spain).Tió EGaig CGiner-Soriano MRomero OJurado MJSansa GPujol MSans OÁlvarez-Guerrico ICaballol NJimenez MBecerra JLEscartin AMonasterio CMolins ABove AViña JIranzo ACambrodi RCalvo GMorros RSantamaria J*cataplexy*epidemiology*narcolepsy type 1*narcolepsy type 2Previous studies have estimated an overall prevalence for narcolepsy between 15 and 70 cases per 100 000 inhabitants. We aimed to estimate the prevalence of narcolepsy in Catalunya (Catalonia), a north-east region of Spain (7 424 754 inhabitants), on 31 December 2014 by identifying all living subjects diagnosed with narcolepsy. First, we identified patients diagnosed by one of the 13 sleep, paediatric or neurological departments that perform tests regularly to diagnose narcolepsy. In a second phase, we searched for additional patients with narcolepsy in a clinical database of the primary health-care system. Clinical files were reviewed and narcolepsy diagnosis validated according to the Brighton Collaboration case definitions. Three hundred and twenty-five patients had a validated diagnosis of narcolepsy in the specialized centres (mean age: 44.6 years, range: 6-89; male: 60.3%; 85% with narcolepsy type 1), including 17.8% cases in Brighton, definition level 1, 62.5% in level 2, 15.4% in level 3 and 4.3% in level 4a. The overall prevalence for narcolepsy was 4.4; 3.7 for narcolepsy type 1 and 0.7 cases per 100 000 inhabitants for narcolepsy type 2. Fifty-six additional narcoleptic patients were identified in the primary health-care system, increasing the overall prevalence to 5.2 cases per 100 000 inhabitants. Prevalence rates for narcolepsy type 1 increased from childhood to adulthood, but in subjects aged more than 50 years there was a substantial drop in prevalence rates, suggesting the presence of a significant pool of undiagnosed cases in this population. Narcolepsy can be considered a rare neurological disorder in Catalunya.WILEY2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13243JOURNAL OF SLEEP RESEARCHISSN: 09621105ISSNe: 13652869reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:dnet:r-fsjd______::bcc1b8e361e088a767fca135e59abe5e2026-05-27T12:37:41Z
dc.title.none.fl_str_mv The prevalence of narcolepsy in Catalunya (Spain).
title The prevalence of narcolepsy in Catalunya (Spain).
spellingShingle The prevalence of narcolepsy in Catalunya (Spain).
Tió E
*cataplexy
*epidemiology
*narcolepsy type 1
*narcolepsy type 2
title_short The prevalence of narcolepsy in Catalunya (Spain).
title_full The prevalence of narcolepsy in Catalunya (Spain).
title_fullStr The prevalence of narcolepsy in Catalunya (Spain).
title_full_unstemmed The prevalence of narcolepsy in Catalunya (Spain).
title_sort The prevalence of narcolepsy in Catalunya (Spain).
dc.creator.none.fl_str_mv Tió E
Gaig C
Giner-Soriano M
Romero O
Jurado MJ
Sansa G
Pujol M
Sans O
Álvarez-Guerrico I
Caballol N
Jimenez M
Becerra JL
Escartin A
Monasterio C
Molins A
Bove A
Viña J
Iranzo A
Cambrodi R
Calvo G
Morros R
Santamaria J
author Tió E
author_facet Tió E
Gaig C
Giner-Soriano M
Romero O
Jurado MJ
Sansa G
Pujol M
Sans O
Álvarez-Guerrico I
Caballol N
Jimenez M
Becerra JL
Escartin A
Monasterio C
Molins A
Bove A
Viña J
Iranzo A
Cambrodi R
Calvo G
Morros R
Santamaria J
author_role author
author2 Gaig C
Giner-Soriano M
Romero O
Jurado MJ
Sansa G
Pujol M
Sans O
Álvarez-Guerrico I
Caballol N
Jimenez M
Becerra JL
Escartin A
Monasterio C
Molins A
Bove A
Viña J
Iranzo A
Cambrodi R
Calvo G
Morros R
Santamaria J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv *cataplexy
*epidemiology
*narcolepsy type 1
*narcolepsy type 2
topic *cataplexy
*epidemiology
*narcolepsy type 1
*narcolepsy type 2
description Previous studies have estimated an overall prevalence for narcolepsy between 15 and 70 cases per 100 000 inhabitants. We aimed to estimate the prevalence of narcolepsy in Catalunya (Catalonia), a north-east region of Spain (7 424 754 inhabitants), on 31 December 2014 by identifying all living subjects diagnosed with narcolepsy. First, we identified patients diagnosed by one of the 13 sleep, paediatric or neurological departments that perform tests regularly to diagnose narcolepsy. In a second phase, we searched for additional patients with narcolepsy in a clinical database of the primary health-care system. Clinical files were reviewed and narcolepsy diagnosis validated according to the Brighton Collaboration case definitions. Three hundred and twenty-five patients had a validated diagnosis of narcolepsy in the specialized centres (mean age: 44.6 years, range: 6-89; male: 60.3%; 85% with narcolepsy type 1), including 17.8% cases in Brighton, definition level 1, 62.5% in level 2, 15.4% in level 3 and 4.3% in level 4a. The overall prevalence for narcolepsy was 4.4; 3.7 for narcolepsy type 1 and 0.7 cases per 100 000 inhabitants for narcolepsy type 2. Fifty-six additional narcoleptic patients were identified in the primary health-care system, increasing the overall prevalence to 5.2 cases per 100 000 inhabitants. Prevalence rates for narcolepsy type 1 increased from childhood to adulthood, but in subjects aged more than 50 years there was a substantial drop in prevalence rates, suggesting the presence of a significant pool of undiagnosed cases in this population. Narcolepsy can be considered a rare neurological disorder in Catalunya.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13243
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13243
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv JOURNAL OF SLEEP RESEARCH
ISSN: 09621105
ISSNe: 13652869
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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