Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East

BACKGROUND: The Global Burden of Disease 2010 study reported the relative size of major depressive disorder (MDD) burden to be greater in the Middle East and North Africa than anywhere else. However, little research has been carried out to examine the comparative effectiveness of antidepressants in...

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Autores: Hong, Jihyung, Novick, Diego, Moneta, Maria Victoria, El-Shafei, Ahmed, Dueñas, Héctor, Haro Abad, Josep Maria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/124247
Acceso en línea:https://hdl.handle.net/2445/124247
Access Level:acceso abierto
Palabra clave:Depressió psíquica
Antidepressius
Farmacologia
Assistència psiquiàtrica
Orient Mitjà
Àfrica del Nord
Mental depression
Antidepressants
Pharmacology
Mental health services
Middle East
Africa, North
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spelling Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle EastHong, JihyungNovick, DiegoMoneta, Maria VictoriaEl-Shafei, AhmedDueñas, HéctorHaro Abad, Josep MariaDepressió psíquicaAntidepressiusFarmacologiaAssistència psiquiàtricaOrient MitjàÀfrica del NordMental depressionAntidepressantsPharmacologyMental health servicesMiddle EastAfrica, NorthBACKGROUND: The Global Burden of Disease 2010 study reported the relative size of major depressive disorder (MDD) burden to be greater in the Middle East and North Africa than anywhere else. However, little research has been carried out to examine the comparative effectiveness of antidepressants in this region. OBJECTIVE: To assess and compare functioning levels in Middle Eastern patients with MDD treated with either duloxetine or a selective serotonin reuptake inhibitor (SSRI), and to examine the impacts of depression-related pain on functioning by the type of treatment. METHOD: This post-hoc analysis, which focused on Middle Eastern patients, used data from a 6-month prospective observational study that included 1,549 MDD patients without sexual dysfunction. Levels of functional impairment and depression-related pain were assessed using the Sheehan Disability Scale (SDS) and the modified Somatic Symptom Inventory, respectively. A mixed model with repeated measures (MMRM) was employed. RESULTS: The mean age of the patients was 37.3 (SD=8.4) years, and 34.6% were female. Patient functioning was, on average, moderately impaired at baseline, but improved substantially during follow-up in both the duloxetine (n=152) and the SSRI (n=123) cohorts. The MMRM results showed a lower level of functional impairment at 24 weeks in the duloxetine cohort than in the SSRI cohort (p<0.001). Pain severity at baseline was positively associated with functional impairment during follow-up only in the SSRI cohort (p=0.003). CONCLUSION: Duloxetine-treated MDD patients achieved better functioning than SSRI-treated patients. This treatment difference was partly driven by depression-related pain.BioMed Central2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/124247Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.2174/1745017901713010145Clinical practice and epidemiology in mental health : CP & EMH, 2017, vol. 13, p. 145-155https://doi.org/10.2174/1745017901713010145cc-by (c) Hong, Jihyung et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1242472026-05-27T06:46:51Z
dc.title.none.fl_str_mv Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East
title Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East
spellingShingle Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East
Hong, Jihyung
Depressió psíquica
Antidepressius
Farmacologia
Assistència psiquiàtrica
Orient Mitjà
Àfrica del Nord
Mental depression
Antidepressants
Pharmacology
Mental health services
Middle East
Africa, North
title_short Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East
title_full Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East
title_fullStr Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East
title_full_unstemmed Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East
title_sort Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East
dc.creator.none.fl_str_mv Hong, Jihyung
Novick, Diego
Moneta, Maria Victoria
El-Shafei, Ahmed
Dueñas, Héctor
Haro Abad, Josep Maria
author Hong, Jihyung
author_facet Hong, Jihyung
Novick, Diego
Moneta, Maria Victoria
El-Shafei, Ahmed
Dueñas, Héctor
Haro Abad, Josep Maria
author_role author
author2 Novick, Diego
Moneta, Maria Victoria
El-Shafei, Ahmed
Dueñas, Héctor
Haro Abad, Josep Maria
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Depressió psíquica
Antidepressius
Farmacologia
Assistència psiquiàtrica
Orient Mitjà
Àfrica del Nord
Mental depression
Antidepressants
Pharmacology
Mental health services
Middle East
Africa, North
topic Depressió psíquica
Antidepressius
Farmacologia
Assistència psiquiàtrica
Orient Mitjà
Àfrica del Nord
Mental depression
Antidepressants
Pharmacology
Mental health services
Middle East
Africa, North
description BACKGROUND: The Global Burden of Disease 2010 study reported the relative size of major depressive disorder (MDD) burden to be greater in the Middle East and North Africa than anywhere else. However, little research has been carried out to examine the comparative effectiveness of antidepressants in this region. OBJECTIVE: To assess and compare functioning levels in Middle Eastern patients with MDD treated with either duloxetine or a selective serotonin reuptake inhibitor (SSRI), and to examine the impacts of depression-related pain on functioning by the type of treatment. METHOD: This post-hoc analysis, which focused on Middle Eastern patients, used data from a 6-month prospective observational study that included 1,549 MDD patients without sexual dysfunction. Levels of functional impairment and depression-related pain were assessed using the Sheehan Disability Scale (SDS) and the modified Somatic Symptom Inventory, respectively. A mixed model with repeated measures (MMRM) was employed. RESULTS: The mean age of the patients was 37.3 (SD=8.4) years, and 34.6% were female. Patient functioning was, on average, moderately impaired at baseline, but improved substantially during follow-up in both the duloxetine (n=152) and the SSRI (n=123) cohorts. The MMRM results showed a lower level of functional impairment at 24 weeks in the duloxetine cohort than in the SSRI cohort (p<0.001). Pain severity at baseline was positively associated with functional impairment during follow-up only in the SSRI cohort (p=0.003). CONCLUSION: Duloxetine-treated MDD patients achieved better functioning than SSRI-treated patients. This treatment difference was partly driven by depression-related pain.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/124247
url https://hdl.handle.net/2445/124247
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.2174/1745017901713010145
Clinical practice and epidemiology in mental health : CP & EMH, 2017, vol. 13, p. 145-155
https://doi.org/10.2174/1745017901713010145
dc.rights.none.fl_str_mv cc-by (c) Hong, Jihyung et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Hong, Jihyung et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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