Development and validation of the Neuro-Score: a specific scale to detect and monitor cognitive impairment in kidney or liver transplant recipients

We created and validated the Neuro-Score, a specific scale to detect and monitor cognitive impairment, including mild stages, in kidney or liver transplant recipients. A qualitative study was conducted to define a preliminary set of 62 items. Item reduction was performed using exploratory factor ana...

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Detalhes bibliográficos
Autores: Moreso, Francesc, Antonio Pons Miñano, José, Sánchez Fructuoso, Ana, Jacas, Carlos, Alegret, Montserrat, Ferrer, Montserrat, Colmenero, Jordi, Andrés Belmonte, Amado, López Jiménez, Verónica, Pascual, Sonia, Mazuecos Blanca, Auxiliadora, Ventura Galiano, Ana Paz, Cachero, Alba, Rivero, Antonio, Crespo, Marta, Cuadrado, Antonio, Caballero Marcos, Arantxa, Gonzalez Diéguez, Maria Luisa, Almohalla Alvarez, Carolina, Maruri Kareaga, Naroa, Alamo Martinez, Jose M., Pagano, Giulia, Nuño Santana, Enriqueta, Torres, Irina B., Pérez Flores, Isabel, Alonso Titos, Juana, Rodríguez Soler, María, Martinez Alarcón, Laura, García Álvarez, Teresa María, Beneyto Castelló, Isabel, Gonzalez Vilatarsana, Emma, Miras, Francesc, Gómez Bravo, Miguel Ángel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/221932
Acesso em linha:https://hdl.handle.net/2445/221932
Access Level:acceso abierto
Palavra-chave:Trastorns de la cognició
Trasplantament renal
Trasplantament hepàtic
Hepatic transplantation
Cognition disorders
Kidney transplantation
Descrição
Resumo:We created and validated the Neuro-Score, a specific scale to detect and monitor cognitive impairment, including mild stages, in kidney or liver transplant recipients. A qualitative study was conducted to define a preliminary set of 62 items. Item reduction was performed using exploratory factor analysis. Confirmatory factor analysis assessed the adequacy of the factorial solution. The total scores of the Neuro-Score and mini-mental state examination were compared. Responsiveness to change was evaluated from visit 1 (baseline) to 2A (18 months later) and temporal stability from visit 2A to 2B (1-2 weeks later). Factor analysis showed 11 factors with an eigenvalue of >1. Confirmatory factor analysis yielded a logical solution with 1 factor and 11 items that explained 27.9% of the variance. The final model showed satisfactory internal consistency (Cronbach alpha- 0.82). A weak negative correlation was found between Neuro-Score and mini-mental state examination total scores (Pearson r--0.12; P-.0095). The Neuro-Score responsiveness to change was demonstrated (P-.022). No significant differences in the total score were observed between visits 2A and 2B, supporting the Neuro-Score temporal stability. The Neuro-Score scale is a simple, reliable, self-administered, easy-to-interpret, and consistent 11-item scale to detect and monitor cognitive impairment in kidney and liver transplant recipients.

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