Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies

Schillemans, Tessa; Iszatt, Nina; Remy, Sylvie; Schoeters, Greet; Fernández, Mariana F; D'Cruz, Shereen Cynthia; Desalegn, Anteneh; Haug, Line S; Lignell, Sanna; Lindroos, Anna Karin; Fábelová, Lucia; Palkovicova Murinova, Lubica; Kosjek, Tina; Tkalec, Žiga; Gabriel, Catherine; Sarigiannis, Denis; Pedraza-Diaz, Susana; Esteban-Lopez, Marta; Castaño, Argelia; Rambaud, Loïc; Riou, Margaux; Pauwels, Sara; Vanlarebeke, Nik; Kolossa-Gehring, Marike; Vogel, Nina; Uhl, Maria; Govarts, Eva; Åkesson, Agneta

Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies

Per- and polyfluoroalkyl substances (PFAS) are widespread pollutants that may impact youth adiposity patterns. We investigated cross-sectional associations between PFAS and body mass index (BMI) in teenagers/adolescents across nine European countries within the Human Biomonitoring for Europe (HBM4EU...

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Detalhes bibliográficos
Autores:	Schillemans, Tessa, Iszatt, Nina, Remy, Sylvie, Schoeters, Greet, Fernández, Mariana F, D'Cruz, Shereen Cynthia, Desalegn, Anteneh, Haug, Line S, Lignell, Sanna, Lindroos, Anna Karin, Fábelová, Lucia, Palkovicova Murinova, Lubica, Kosjek, Tina, Tkalec, Žiga, Gabriel, Catherine, Sarigiannis, Denis, Pedraza-Diaz, Susana, Esteban-Lopez, Marta, Castaño, Argelia, Rambaud, Loïc, Riou, Margaux, Pauwels, Sara, Vanlarebeke, Nik, Kolossa-Gehring, Marike, Vogel, Nina, Uhl, Maria, Govarts, Eva, Åkesson, Agneta
Formato:	artículo
Fecha de publicación:	2023
País:	España
Recursos:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/16107
Acesso em linha:	http://hdl.handle.net/20.500.12105/16107
Access Level:	acceso abierto
Palavra-chave:	Fluorocarbons Environmental Pollutants Alkanesulfonic Acids Adolescent Humans Body Mass Index Cross-Sectional Studies Prospective Studies

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spelling	Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studiesSchillemans, TessaIszatt, NinaRemy, SylvieSchoeters, GreetFernández, Mariana FD'Cruz, Shereen CynthiaDesalegn, AntenehHaug, Line SLignell, SannaLindroos, Anna KarinFábelová, LuciaPalkovicova Murinova, LubicaKosjek, TinaTkalec, ŽigaGabriel, CatherineSarigiannis, DenisPedraza-Diaz, SusanaEsteban-Lopez, MartaCastaño, ArgeliaRambaud, LoïcRiou, MargauxPauwels, SaraVanlarebeke, NikKolossa-Gehring, MarikeVogel, NinaUhl, MariaGovarts, EvaÅkesson, AgnetaFluorocarbonsEnvironmental PollutantsAlkanesulfonic AcidsAdolescentHumansBody Mass IndexCross-Sectional StudiesProspective StudiesPer- and polyfluoroalkyl substances (PFAS) are widespread pollutants that may impact youth adiposity patterns. We investigated cross-sectional associations between PFAS and body mass index (BMI) in teenagers/adolescents across nine European countries within the Human Biomonitoring for Europe (HBM4EU) initiative. We used data from 1957 teenagers (12-18 yrs) that were part of the HBM4EU aligned studies, consisting of nine HBM studies (NEBII, Norway; Riksmaten Adolescents 2016-17, Sweden; PCB cohort (follow-up), Slovakia; SLO CRP, Slovenia; CROME, Greece; BEA, Spain; ESTEBAN, France; FLEHS IV, Belgium; GerES V-sub, Germany). Twelve PFAS were measured in blood, whilst weight and height were measured by field nurse/physician or self-reported in questionnaires. We assessed associations between PFAS and age- and sex-adjusted BMI z-scores using linear and logistic regression adjusted for potential confounders. Random-effects meta-analysis and mixed effects models were used to pool studies. We assessed mixture effects using molar sums of exposure biomarkers with toxicological/structural similarities and quantile g-computation. In all studies, the highest concentrations of PFAS were PFOS (medians ranging from 1.34 to 2.79 μg/L). There was a tendency for negative associations with BMI z-scores for all PFAS (except for PFHxS and PFHpS), which was borderline significant for the molar sum of [PFOA and PFNA] and significant for single PFOA [β-coefficient (95% CI) per interquartile range fold change = -0.06 (-0.17, 0.00) and -0.08 (-0.15, -0.01), respectively]. Mixture assessment indicated similar negative associations of the total mixture of [PFOA, PFNA, PFHxS and PFOS] with BMI z-score, but not all compounds showed associations in the same direction: whilst [PFOA, PFNA and PFOS] were negatively associated, [PFHxS] associated positively with BMI z-score. Our results indicated a tendency for associations of relatively low PFAS concentrations with lower BMI in European teenagers. More prospective research is needed to investigate this potential relationship and its implications for health later in life.ElsevierUnión Europea. Comisión Europea. H2020Swedish Research Council20232023-05-2220232023-01-0120232023-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/20.500.12105/16107reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 733032open accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/161072026-06-12T12:43:37Z
dc.title.none.fl_str_mv	Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies
title	Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies
spellingShingle	Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies Schillemans, Tessa Fluorocarbons Environmental Pollutants Alkanesulfonic Acids Adolescent Humans Body Mass Index Cross-Sectional Studies Prospective Studies
title_short	Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies
title_full	Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies
title_fullStr	Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies
title_full_unstemmed	Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies
title_sort	Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies
dc.creator.none.fl_str_mv	Schillemans, Tessa Iszatt, Nina Remy, Sylvie Schoeters, Greet Fernández, Mariana F D'Cruz, Shereen Cynthia Desalegn, Anteneh Haug, Line S Lignell, Sanna Lindroos, Anna Karin Fábelová, Lucia Palkovicova Murinova, Lubica Kosjek, Tina Tkalec, Žiga Gabriel, Catherine Sarigiannis, Denis Pedraza-Diaz, Susana Esteban-Lopez, Marta Castaño, Argelia Rambaud, Loïc Riou, Margaux Pauwels, Sara Vanlarebeke, Nik Kolossa-Gehring, Marike Vogel, Nina Uhl, Maria Govarts, Eva Åkesson, Agneta
author	Schillemans, Tessa
author_facet	Schillemans, Tessa Iszatt, Nina Remy, Sylvie Schoeters, Greet Fernández, Mariana F D'Cruz, Shereen Cynthia Desalegn, Anteneh Haug, Line S Lignell, Sanna Lindroos, Anna Karin Fábelová, Lucia Palkovicova Murinova, Lubica Kosjek, Tina Tkalec, Žiga Gabriel, Catherine Sarigiannis, Denis Pedraza-Diaz, Susana Esteban-Lopez, Marta Castaño, Argelia Rambaud, Loïc Riou, Margaux Pauwels, Sara Vanlarebeke, Nik Kolossa-Gehring, Marike Vogel, Nina Uhl, Maria Govarts, Eva Åkesson, Agneta
author_role	author
author2	Iszatt, Nina Remy, Sylvie Schoeters, Greet Fernández, Mariana F D'Cruz, Shereen Cynthia Desalegn, Anteneh Haug, Line S Lignell, Sanna Lindroos, Anna Karin Fábelová, Lucia Palkovicova Murinova, Lubica Kosjek, Tina Tkalec, Žiga Gabriel, Catherine Sarigiannis, Denis Pedraza-Diaz, Susana Esteban-Lopez, Marta Castaño, Argelia Rambaud, Loïc Riou, Margaux Pauwels, Sara Vanlarebeke, Nik Kolossa-Gehring, Marike Vogel, Nina Uhl, Maria Govarts, Eva Åkesson, Agneta
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Unión Europea. Comisión Europea. H2020 Swedish Research Council
dc.subject.none.fl_str_mv	Fluorocarbons Environmental Pollutants Alkanesulfonic Acids Adolescent Humans Body Mass Index Cross-Sectional Studies Prospective Studies
topic	Fluorocarbons Environmental Pollutants Alkanesulfonic Acids Adolescent Humans Body Mass Index Cross-Sectional Studies Prospective Studies
description	Per- and polyfluoroalkyl substances (PFAS) are widespread pollutants that may impact youth adiposity patterns. We investigated cross-sectional associations between PFAS and body mass index (BMI) in teenagers/adolescents across nine European countries within the Human Biomonitoring for Europe (HBM4EU) initiative. We used data from 1957 teenagers (12-18 yrs) that were part of the HBM4EU aligned studies, consisting of nine HBM studies (NEBII, Norway; Riksmaten Adolescents 2016-17, Sweden; PCB cohort (follow-up), Slovakia; SLO CRP, Slovenia; CROME, Greece; BEA, Spain; ESTEBAN, France; FLEHS IV, Belgium; GerES V-sub, Germany). Twelve PFAS were measured in blood, whilst weight and height were measured by field nurse/physician or self-reported in questionnaires. We assessed associations between PFAS and age- and sex-adjusted BMI z-scores using linear and logistic regression adjusted for potential confounders. Random-effects meta-analysis and mixed effects models were used to pool studies. We assessed mixture effects using molar sums of exposure biomarkers with toxicological/structural similarities and quantile g-computation. In all studies, the highest concentrations of PFAS were PFOS (medians ranging from 1.34 to 2.79 μg/L). There was a tendency for negative associations with BMI z-scores for all PFAS (except for PFHxS and PFHpS), which was borderline significant for the molar sum of [PFOA and PFNA] and significant for single PFOA [β-coefficient (95% CI) per interquartile range fold change = -0.06 (-0.17, 0.00) and -0.08 (-0.15, -0.01), respectively]. Mixture assessment indicated similar negative associations of the total mixture of [PFOA, PFNA, PFHxS and PFOS] with BMI z-score, but not all compounds showed associations in the same direction: whilst [PFOA, PFNA and PFOS] were negatively associated, [PFHxS] associated positively with BMI z-score. Our results indicated a tendency for associations of relatively low PFAS concentrations with lower BMI in European teenagers. More prospective research is needed to investigate this potential relationship and its implications for health later in life.
publishDate	2023
dc.date.none.fl_str_mv	2023 2023-05-22 2023 2023-01-01 2023 2023-01-01
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/16107
url	http://hdl.handle.net/20.500.12105/16107
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 733032
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Cross-sectional associations between exposure to per- and polyfluoroalkyl substances and body mass index among European teenagers in the HBM4EU aligned studies

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