Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts

Background: There is limited epidemiological evidence on the association of prenatal exposure to phthalates and synthetic phenols with altered pubertal timing. Objective: To examine the association of prenatal exposure to phthalates, bisphenol A (BPA), parabens, benzophenone 3 (BP-3), and triclosan...

Descripción completa

Detalles Bibliográficos
Autores: Freire, Carmen, Castiello, Francesca, Babarro, Izaro, Anguita Ruiz, Augusto, Casas Sanahuja, Maribel, Vrijheid, Martine, Sarzo, Blanca, Beneito, Andrea, Kadawathagedara, Manik, Philippat, Claire, Thomsen, Cathrine, Sakhi, Amrit Kaur, López Espinosa, Maria José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/68705
Acceso en línea:http://hdl.handle.net/10230/68705
http://dx.doi.org/10.1016/j.ijheh.2024.114418
Access Level:acceso abierto
Palabra clave:Bisphenol a
Endocrine-disrupting chemicals
Phenols
Phthalates
Puberty
id ES_50bd7577c68ef7ce710affa55a7febef
oai_identifier_str oai:repositori.upf.edu:10230/68705
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts
title Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts
spellingShingle Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts
Freire, Carmen
Bisphenol a
Endocrine-disrupting chemicals
Phenols
Phthalates
Puberty
title_short Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts
title_full Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts
title_fullStr Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts
title_full_unstemmed Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts
title_sort Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts
dc.creator.none.fl_str_mv Freire, Carmen
Castiello, Francesca
Babarro, Izaro
Anguita Ruiz, Augusto
Casas Sanahuja, Maribel
Vrijheid, Martine
Sarzo, Blanca
Beneito, Andrea
Kadawathagedara, Manik
Philippat, Claire
Thomsen, Cathrine
Sakhi, Amrit Kaur
López Espinosa, Maria José
author Freire, Carmen
author_facet Freire, Carmen
Castiello, Francesca
Babarro, Izaro
Anguita Ruiz, Augusto
Casas Sanahuja, Maribel
Vrijheid, Martine
Sarzo, Blanca
Beneito, Andrea
Kadawathagedara, Manik
Philippat, Claire
Thomsen, Cathrine
Sakhi, Amrit Kaur
López Espinosa, Maria José
author_role author
author2 Castiello, Francesca
Babarro, Izaro
Anguita Ruiz, Augusto
Casas Sanahuja, Maribel
Vrijheid, Martine
Sarzo, Blanca
Beneito, Andrea
Kadawathagedara, Manik
Philippat, Claire
Thomsen, Cathrine
Sakhi, Amrit Kaur
López Espinosa, Maria José
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bisphenol a
Endocrine-disrupting chemicals
Phenols
Phthalates
Puberty
topic Bisphenol a
Endocrine-disrupting chemicals
Phenols
Phthalates
Puberty
description Background: There is limited epidemiological evidence on the association of prenatal exposure to phthalates and synthetic phenols with altered pubertal timing. Objective: To examine the association of prenatal exposure to phthalates, bisphenol A (BPA), parabens, benzophenone 3 (BP-3), and triclosan (TCS) with pubertal development in girls and boys from three European cohorts. Methods: Urinary metabolites of six different phthalate diesters (DEP, DiBP, DnBP, BBzP, DEHP, and DiNP), BPA, methyl- (MePB), ethyl- (EtPB), propyl- (PrPB), and butyl-paraben (BuPB), BP-3, and TCS were quantified in one or two (1st and 3rd trimester) urine samples collected during pregnancy (1999-2008) from mothers in three birth cohorts: INMA (Spain), EDEN (France), and MoBa (Norway). Pubertal development of their children was assessed at a single visit at age 7-12 years (579 girls, 644 boys) using the parent-reported Pubertal Development Scale (PDS). Mixed-effect Poisson and g-computation and Bayesian Kernel Machine Regression (BKMR) were employed to examine associations of individual and combined prenatal chemical exposure, respectively, with the probability of overall pubertal onset, adrenarche, and gonadarche (stage 2+) in girls and boys. Effect modification by child body mass index (BMI) was also assessed. Results: Maternal concentrations of the molar sum of DEHP and of DiNP metabolites were associated with a slightly higher probability of having started puberty in boys (relative risk, RR [95% CI] = 1.13 [0.98-1.30] and 1.20 [1.06-1.34], respectively, for a two-fold increase in concentrations), with a stronger association for DiNP in boys with overweight or obesity. In contrast, BPA, BuPB, EtPB, and PrPB were associated with a lower probability of pubertal onset, adrenarche, and/or gonadarche in all boys (e.g. overall puberty, BPA: RR [95% CI] = 0.93 [0.85-1.01] and BuPB: 0.95 [0.90-1.00], respectively), and the association with BPA was stronger in boys with underweight/normal weight. In girls, MEHP and BPA were associated with delayed gonadarche in those with underweight/normal weight (RR [95% CI] = 0.86 [0.77-0.95] and 0.90 [0.84-0.97], respectively). Most of these associations were trimester specific. However, the chemical mixture was not associated with any pubertal outcome in boys or girls. Conclusions: Prenatal exposure to certain phthalates and synthetic phenols such as BPA may impact the pubertal development of boys, and weight status may modify this effect. BPA may also alter the pubertal development of girls.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/68705
http://dx.doi.org/10.1016/j.ijheh.2024.114418
url http://hdl.handle.net/10230/68705
http://dx.doi.org/10.1016/j.ijheh.2024.114418
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Int J Hyg Environ Health. 2024 Aug;261:114418
info:eu-repo/grantAgreement/EC/FP7/308333
info:eu-repo/grantAgreement/EC/H2020/874583
info:eu-repo/grantAgreement/EC/FP7/261357
info:eu-repo/grantAgreement/EC/FP7/603794
info:eu-repo/grantAgreement/EC/H2020/634453
info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407910363136000
spelling Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohortsFreire, CarmenCastiello, FrancescaBabarro, IzaroAnguita Ruiz, AugustoCasas Sanahuja, MaribelVrijheid, MartineSarzo, BlancaBeneito, AndreaKadawathagedara, ManikPhilippat, ClaireThomsen, CathrineSakhi, Amrit KaurLópez Espinosa, Maria JoséBisphenol aEndocrine-disrupting chemicalsPhenolsPhthalatesPubertyBackground: There is limited epidemiological evidence on the association of prenatal exposure to phthalates and synthetic phenols with altered pubertal timing. Objective: To examine the association of prenatal exposure to phthalates, bisphenol A (BPA), parabens, benzophenone 3 (BP-3), and triclosan (TCS) with pubertal development in girls and boys from three European cohorts. Methods: Urinary metabolites of six different phthalate diesters (DEP, DiBP, DnBP, BBzP, DEHP, and DiNP), BPA, methyl- (MePB), ethyl- (EtPB), propyl- (PrPB), and butyl-paraben (BuPB), BP-3, and TCS were quantified in one or two (1st and 3rd trimester) urine samples collected during pregnancy (1999-2008) from mothers in three birth cohorts: INMA (Spain), EDEN (France), and MoBa (Norway). Pubertal development of their children was assessed at a single visit at age 7-12 years (579 girls, 644 boys) using the parent-reported Pubertal Development Scale (PDS). Mixed-effect Poisson and g-computation and Bayesian Kernel Machine Regression (BKMR) were employed to examine associations of individual and combined prenatal chemical exposure, respectively, with the probability of overall pubertal onset, adrenarche, and gonadarche (stage 2+) in girls and boys. Effect modification by child body mass index (BMI) was also assessed. Results: Maternal concentrations of the molar sum of DEHP and of DiNP metabolites were associated with a slightly higher probability of having started puberty in boys (relative risk, RR [95% CI] = 1.13 [0.98-1.30] and 1.20 [1.06-1.34], respectively, for a two-fold increase in concentrations), with a stronger association for DiNP in boys with overweight or obesity. In contrast, BPA, BuPB, EtPB, and PrPB were associated with a lower probability of pubertal onset, adrenarche, and/or gonadarche in all boys (e.g. overall puberty, BPA: RR [95% CI] = 0.93 [0.85-1.01] and BuPB: 0.95 [0.90-1.00], respectively), and the association with BPA was stronger in boys with underweight/normal weight. In girls, MEHP and BPA were associated with delayed gonadarche in those with underweight/normal weight (RR [95% CI] = 0.86 [0.77-0.95] and 0.90 [0.84-0.97], respectively). Most of these associations were trimester specific. However, the chemical mixture was not associated with any pubertal outcome in boys or girls. Conclusions: Prenatal exposure to certain phthalates and synthetic phenols such as BPA may impact the pubertal development of boys, and weight status may modify this effect. BPA may also alter the pubertal development of girls.The HELIX Project has received funding from the European Community's Seventh Framework Programme (FP7/2007–2013) under grant agreement no 308333. This study was also supported in part by European Union grant agreement number 874583 (ATHLETE) and research grants from the Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP) and Instituto de Salud Carlos III (ISCIII) supported by European Development Fund (FEDER) (grant no. PI13/1944, PI14/00891, PI17/01194), and from RecerCaixa (Register number: 2010ACUP 00349) and CIBER-ISCIII (Mobility Actions, 2024), MICIU-FEDER. INMA: This research would not have been achieved without the selfless collaboration of the INMA families who took part in the study. INMA-Gipuzkoa cohort was funded by grants from ISCIII (PI06/0867, PI09/00090, PI13/02187, PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089, and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). INMA-Sabadell cohort was funded by grants from ISCIII (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, grant CEX 2018-000806-S funded by MCIN/AEI/10.13039/501100011033, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF 2012-32991 incl. FEDER funds), Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010), and EU Commission (grant no. 261357, 603794, and 634453). INMA-Valencia was funded by grants from ISCIII (PI11/02591, PI13/1944, PI14/00891, P117/00663 and PI17/01526; Miguel Servet-FEDER (CP11/00178, CP15/00025, and CP20/0006) and Generalitat Valenciana (UGP-15-249).Elsevier202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/68705http://dx.doi.org/10.1016/j.ijheh.2024.114418reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésInt J Hyg Environ Health. 2024 Aug;261:114418info:eu-repo/grantAgreement/EC/FP7/308333info:eu-repo/grantAgreement/EC/H2020/874583info:eu-repo/grantAgreement/EC/FP7/261357info:eu-repo/grantAgreement/EC/FP7/603794info:eu-repo/grantAgreement/EC/H2020/634453info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991© 2024 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/687052026-06-12T07:21:37Z
score 15,81155

Similares en LA Referencia