Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/ obesity—A PREVIEW randomized clinical trial

Background: Pubertal insulin resistance (IR) is associated with increased risk of type 2 diabetes mellitus development in adolescents with overweight/obesity. Objectives: The PREVIEW study was a randomized parallel trial assessing the change in IR, analyzed by Homeostatic Model Assessment of IR (HOM...

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Autores: Dorenbos, E. (Elke)|||/items/1c6cb629-31dc-4cee-a905-3237b33940b3, Drummen, M. (Mathijs)|||/items/b7e9354a-1d07-4ebf-82f2-4d98ad1f5df6, Adam, T.C. (Tanja C.)|||/items/46bd1c0d-b2ba-4aa9-8d5e-7fd678912dd3, Rijks, J. (Jesse)|||/items/05a3f862-72b7-4fad-9570-28e91bda7323, Winkens, B. (Bjorn)|||/items/05a3b97f-019d-4a71-a5f4-ffe0afc362f2, Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131, Navas-Carretero, S. (Santiago)|||/items/95b4a938-bf11-409b-bc49-672a5b5fd20e, Stratton, G. (Gareth)|||/items/eca0ebdf-bd8a-47be-9460-94eeb20b9586, Swindell, N. (Nils)|||/items/d4657a8e-14d6-42ec-ac23-f769e78dd8da, Stouthart, P. (Pauline)|||/items/865499c5-35df-4619-b319-1a10aa832cd2, Mackintosh, K.A. (Kelly A.)|||/items/c3bd504e-92ea-43fe-bde4-9bb39ffc206b, McNarry, M.A. (Melitta A.)|||/items/c0ba9934-d603-4459-8581-59e4dfd5189a, Tremblay, A. (Angelo)|||/items/8f9c5f99-1a17-449e-a10a-c87c06e41208, Fogelholm, M. (Mikael)|||/items/9776ed76-70b1-4893-8eb9-6516a3a19ead, Raben, A. (Anne)|||/items/a0dd7aa4-c4fc-4661-8066-d76c26173901, Westerterp-Plantenga, M. (Margriet)|||/items/bb75d339-b73a-4a44-b4bf-0f207359fd9c, Vreugdenhil, A. (Anita)|||/items/5f19182d-fab3-4041-80ff-98a3f7653b43
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/114675
Acesso em linha:https://hdl.handle.net/10171/114675
Access Level:acceso abierto
Palavra-chave:Dietary protein
Glycaemic index
Glycaemic load
Physical activity
Pubertal insulin resistance
Descrição
Resumo:Background: Pubertal insulin resistance (IR) is associated with increased risk of type 2 diabetes mellitus development in adolescents with overweight/obesity. Objectives: The PREVIEW study was a randomized parallel trial assessing the change in IR, analyzed by Homeostatic Model Assessment of IR (HOMA-IR), at 2 years after randomization to a high protein vs a moderate protein diet in adolescents with overweight/obesity. It was hypothesized that a high protein/low glycaemic index diet would be superior in reducing IR compared to a medium protein/medium GI diet, in insulin resistant adolescents with overweight or obesity. Methods: Adolescents with overweight/obesity and IR from the Netherlands, United Kingdom and Spain were randomized into a moderate protein/moderate GI (15/55/30En% protein/carbohydrate/fat, GI ≥ 56) or high protein/low GI (25/45/30En% protein/carbohydrate/fat, GI < 50) diet. Anthropometric and cardiometabolic parameters, puberty, dietary intake and physical activity (PA) were measured and effects on HOMA-IR were analyzed. Results: 126 adolescents were included in this study (13.6 ± 2.2 years, BMI z-score 3.04 ± 0.66, HOMA-IR 3.48 ± 2.28, HP n = 68, MP n = 58). At 2 years, changes in protein intake were not significantly different between timepoints or intervention groups and no effects of the intervention on IR were observed. The retention rate was 39%, while no compliance to the diets was observed. Conclusions: The PREVIEW study observed no effect of a high protein/low GI diet on IR in adolescents with overweight/obesity and IR because of lack of feasibility, due to insufficient retention and dietary compliance after 2 years.

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