Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part II: Methodological and clinical recommendations for the diagnosis and follow-up of monoclonal gammopathies

Cárdenas, María C.; García-Sanz, Ramón; Puig, Noemi; Pérez-Surribas, David; Flores-Montero, Juan; Ortiz-Espejo, María; Rubia, Javier de la; Cruz-Iglesias, Elena

Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part II: Methodological and clinical recommendations for the diagnosis and follow-up of monoclonal gammopathies

Monoclonal gammopathies (MG) are a group of clinical entities characterized by the clonal expansion of monoclonal immunoglobulin (M-protein) secreting plasma cells (PC). This document presents the consensus recommendations of the Spanish Society of Laboratory Medicine (SEQCML) and the Spanish Societ...

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Autores:	Cárdenas, María C., García-Sanz, Ramón, Puig, Noemi, Pérez-Surribas, David, Flores-Montero, Juan, Ortiz-Espejo, María, Rubia, Javier de la, Cruz-Iglesias, Elena
Tipo de recurso:	artículo
Fecha de publicación:	2023
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:dnet:digitalcsic_::9cfb4dece88031f7e75a4cfeeca5386a
Acceso en línea:	http://hdl.handle.net/10261/352613
Access Level:	acceso abierto
Palabra clave:	Bone marrow Electrophoresis Capillary Flow cytometry Immunofixation Monoclonal gammopathy of undetermined significance Multiple myeloma

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spelling	Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part II: Methodological and clinical recommendations for the diagnosis and follow-up of monoclonal gammopathiesCárdenas, María C.García-Sanz, RamónPuig, NoemiPérez-Surribas, DavidFlores-Montero, JuanOrtiz-Espejo, MaríaRubia, Javier de laCruz-Iglesias, ElenaBone marrowElectrophoresisCapillaryFlow cytometryImmunofixationMonoclonal gammopathy of undetermined significanceMultiple myelomaMonoclonal gammopathies (MG) are a group of clinical entities characterized by the clonal expansion of monoclonal immunoglobulin (M-protein) secreting plasma cells (PC). This document presents the consensus recommendations of the Spanish Society of Laboratory Medicine (SEQCML) and the Spanish Society of Hematology and Hemotherapy (SEHH) for the study of MG. The recommendations were established based on scientific evidence and the opinion of experts in MG from the clinical laboratory and clinical hematology fields. Recommendations are proposed for the diagnosis of MG and for patient follow-up according to the type of MG and whether or not the patient is undergoing treatment, and to monitor the disease stability, response to therapy and disease progression. With respect to the diagnosis, we describe the most recent criteria and classification established by the International Myeloma Working Group (IMWG) for multiple myeloma (MM), smoldering MM, monoclonal gammopathy of undermined significance (MGUS) and other related entities. Indications are given about the analytical requirements and application of the different serum and urine laboratory tests (study, detection, identification and measurement of M-protein) and the bone marrow study. Recommendations on the clinical laboratory results report model are established to harmonize and ensure that all relevant information is available, including its content, expression, and interpretive comments.Novartis, Gilead, Astellas, Janssen.Peer reviewedWalter de GruyterNovartisGilead SciencesJanssen Research and DevelopmentConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501application/pdfhttp://hdl.handle.net/10261/352613reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at 10.1515/cclm-2023-0325https://doi.org/10.1515/cclm-2023-0325Síinfo:eu-repo/semantics/openAccessoai:dnet:digitalcsic_::9cfb4dece88031f7e75a4cfeeca5386a2026-05-22T06:33:51Z
dc.title.none.fl_str_mv	Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part II: Methodological and clinical recommendations for the diagnosis and follow-up of monoclonal gammopathies
title	Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part II: Methodological and clinical recommendations for the diagnosis and follow-up of monoclonal gammopathies
spellingShingle	Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part II: Methodological and clinical recommendations for the diagnosis and follow-up of monoclonal gammopathies Cárdenas, María C. Bone marrow Electrophoresis Capillary Flow cytometry Immunofixation Monoclonal gammopathy of undetermined significance Multiple myeloma
title_short	Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part II: Methodological and clinical recommendations for the diagnosis and follow-up of monoclonal gammopathies
title_full	Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part II: Methodological and clinical recommendations for the diagnosis and follow-up of monoclonal gammopathies
title_fullStr	Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part II: Methodological and clinical recommendations for the diagnosis and follow-up of monoclonal gammopathies
title_full_unstemmed	Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part II: Methodological and clinical recommendations for the diagnosis and follow-up of monoclonal gammopathies
title_sort	Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part II: Methodological and clinical recommendations for the diagnosis and follow-up of monoclonal gammopathies
dc.creator.none.fl_str_mv	Cárdenas, María C. García-Sanz, Ramón Puig, Noemi Pérez-Surribas, David Flores-Montero, Juan Ortiz-Espejo, María Rubia, Javier de la Cruz-Iglesias, Elena
author	Cárdenas, María C.
author_facet	Cárdenas, María C. García-Sanz, Ramón Puig, Noemi Pérez-Surribas, David Flores-Montero, Juan Ortiz-Espejo, María Rubia, Javier de la Cruz-Iglesias, Elena
author_role	author
author2	García-Sanz, Ramón Puig, Noemi Pérez-Surribas, David Flores-Montero, Juan Ortiz-Espejo, María Rubia, Javier de la Cruz-Iglesias, Elena
author2_role	author author author author author author author
dc.contributor.none.fl_str_mv	Novartis Gilead Sciences Janssen Research and Development Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv	Bone marrow Electrophoresis Capillary Flow cytometry Immunofixation Monoclonal gammopathy of undetermined significance Multiple myeloma
topic	Bone marrow Electrophoresis Capillary Flow cytometry Immunofixation Monoclonal gammopathy of undetermined significance Multiple myeloma
description	Monoclonal gammopathies (MG) are a group of clinical entities characterized by the clonal expansion of monoclonal immunoglobulin (M-protein) secreting plasma cells (PC). This document presents the consensus recommendations of the Spanish Society of Laboratory Medicine (SEQCML) and the Spanish Society of Hematology and Hemotherapy (SEHH) for the study of MG. The recommendations were established based on scientific evidence and the opinion of experts in MG from the clinical laboratory and clinical hematology fields. Recommendations are proposed for the diagnosis of MG and for patient follow-up according to the type of MG and whether or not the patient is undergoing treatment, and to monitor the disease stability, response to therapy and disease progression. With respect to the diagnosis, we describe the most recent criteria and classification established by the International Myeloma Working Group (IMWG) for multiple myeloma (MM), smoldering MM, monoclonal gammopathy of undermined significance (MGUS) and other related entities. Indications are given about the analytical requirements and application of the different serum and urine laboratory tests (study, detection, identification and measurement of M-protein) and the bone marrow study. Recommendations on the clinical laboratory results report model are established to harmonize and ensure that all relevant information is available, including its content, expression, and interpretive comments.
publishDate	2023
dc.date.none.fl_str_mv	2023 2024 2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10261/352613
url	http://hdl.handle.net/10261/352613
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	The underlying dataset has been published as supplementary material of the article in the publisher platform at 10.1515/cclm-2023-0325 https://doi.org/10.1515/cclm-2023-0325 Sí
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Walter de Gruyter
publisher.none.fl_str_mv	Walter de Gruyter
dc.source.none.fl_str_mv	reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	DIGITAL.CSIC. Repositorio Institucional del CSIC
collection	DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,811543

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