Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary Disease

Background: Chronic Obstructive Pulmonary Disease (COPD) is associated with subclinical systemic atherosclerosis and pulmonary vascular remodelling characterized by intimal hyperplasia and luminal narrowing. We aimed to determine differences in the intimal thickening of systemic and pulmonary arteri...

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Autores: Muñoz Esquerre, Mariana, López Sánchez, Marta, Escobar Campuzano, Ignacio, Huertas, Daniel, Penín, Rosa Maria, Molina Molina, María, Manresa, Federico, Dorca i Sargatal, Jordi, Santos Pérez, Salud
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126946
Acceso en línea:https://hdl.handle.net/2445/126946
Access Level:acceso abierto
Palabra clave:Malalties pulmonars obstructives cròniques
Arterioesclerosi
Chronic obstructive pulmonary diseases
Arteriosclerosis
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spelling Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary DiseaseMuñoz Esquerre, MarianaLópez Sánchez, MartaEscobar Campuzano, IgnacioHuertas, DanielPenín, Rosa MariaMolina Molina, MaríaManresa, FedericoDorca i Sargatal, JordiSantos Pérez, SaludMalalties pulmonars obstructives cròniquesArterioesclerosiChronic obstructive pulmonary diseasesArteriosclerosisBackground: Chronic Obstructive Pulmonary Disease (COPD) is associated with subclinical systemic atherosclerosis and pulmonary vascular remodelling characterized by intimal hyperplasia and luminal narrowing. We aimed to determine differences in the intimal thickening of systemic and pulmonary arteries in COPD subjects and smokers. Secondary aims include comparisons with a non-smokers group; determining the clinical variables associated with systemic and pulmonary intimal thickening, and the correlations between systemic and pulmonary remodelling changes. Methods: All consecutive subjects undergoing lung resection were included and divided into 3 groups: 1) COPD, 2) smokers, and 3) non-smokers. Sections of the 5th intercostal artery and muscular pulmonary arteries were measured by histo-morphometry. Four parameters of intimal thickening were evaluated: 1) percentage of intimal area (%IA), 2) percentage of luminal narrowing, 3) intimal thickness index, and 4) intima-to-media ratio. Results: In the adjusted analysis, the systemic arteries of COPD subjects showed greater intimal thickening (%IA) than those of smokers (15.6 +/- 1.5% vs. 14.2 +/- 1.6%, p = 0.038). In the pulmonary arteries, significant differences were observed for % IA between the 2 groups (37.3 +/- 2.2% vs. 29.3 +/- 2.3%, p = 0.016). Among clinical factors, metabolic syndrome, gender and COPD status were associated with the systemic intimal thickening, while only COPD status was associated with pulmonary intimal thickening. A correlation between the % IA of the systemic and pulmonary arteries was observed (Spearman's rho = 0.46, p = 0.008). Conclusions: Greater intimal thickening in systemic and pulmonary arteries is observed in COPD patients than in smokers. There is a correlation between systemic and pulmonary vascular remodelling in the overall population.Public Library of Science (PLoS)2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/126946Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0152987PLoS One, 2016, vol. 11, num. 4, p. e0152987https://doi.org/10.1371/journal.pone.0152987cc-by (c) Muñoz Esquerre, Mariana et al., 2016http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1269462026-05-27T06:46:51Z
dc.title.none.fl_str_mv Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary Disease
title Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary Disease
spellingShingle Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary Disease
Muñoz Esquerre, Mariana
Malalties pulmonars obstructives cròniques
Arterioesclerosi
Chronic obstructive pulmonary diseases
Arteriosclerosis
title_short Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary Disease
title_full Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary Disease
title_fullStr Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary Disease
title_full_unstemmed Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary Disease
title_sort Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary Disease
dc.creator.none.fl_str_mv Muñoz Esquerre, Mariana
López Sánchez, Marta
Escobar Campuzano, Ignacio
Huertas, Daniel
Penín, Rosa Maria
Molina Molina, María
Manresa, Federico
Dorca i Sargatal, Jordi
Santos Pérez, Salud
author Muñoz Esquerre, Mariana
author_facet Muñoz Esquerre, Mariana
López Sánchez, Marta
Escobar Campuzano, Ignacio
Huertas, Daniel
Penín, Rosa Maria
Molina Molina, María
Manresa, Federico
Dorca i Sargatal, Jordi
Santos Pérez, Salud
author_role author
author2 López Sánchez, Marta
Escobar Campuzano, Ignacio
Huertas, Daniel
Penín, Rosa Maria
Molina Molina, María
Manresa, Federico
Dorca i Sargatal, Jordi
Santos Pérez, Salud
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties pulmonars obstructives cròniques
Arterioesclerosi
Chronic obstructive pulmonary diseases
Arteriosclerosis
topic Malalties pulmonars obstructives cròniques
Arterioesclerosi
Chronic obstructive pulmonary diseases
Arteriosclerosis
description Background: Chronic Obstructive Pulmonary Disease (COPD) is associated with subclinical systemic atherosclerosis and pulmonary vascular remodelling characterized by intimal hyperplasia and luminal narrowing. We aimed to determine differences in the intimal thickening of systemic and pulmonary arteries in COPD subjects and smokers. Secondary aims include comparisons with a non-smokers group; determining the clinical variables associated with systemic and pulmonary intimal thickening, and the correlations between systemic and pulmonary remodelling changes. Methods: All consecutive subjects undergoing lung resection were included and divided into 3 groups: 1) COPD, 2) smokers, and 3) non-smokers. Sections of the 5th intercostal artery and muscular pulmonary arteries were measured by histo-morphometry. Four parameters of intimal thickening were evaluated: 1) percentage of intimal area (%IA), 2) percentage of luminal narrowing, 3) intimal thickness index, and 4) intima-to-media ratio. Results: In the adjusted analysis, the systemic arteries of COPD subjects showed greater intimal thickening (%IA) than those of smokers (15.6 +/- 1.5% vs. 14.2 +/- 1.6%, p = 0.038). In the pulmonary arteries, significant differences were observed for % IA between the 2 groups (37.3 +/- 2.2% vs. 29.3 +/- 2.3%, p = 0.016). Among clinical factors, metabolic syndrome, gender and COPD status were associated with the systemic intimal thickening, while only COPD status was associated with pulmonary intimal thickening. A correlation between the % IA of the systemic and pulmonary arteries was observed (Spearman's rho = 0.46, p = 0.008). Conclusions: Greater intimal thickening in systemic and pulmonary arteries is observed in COPD patients than in smokers. There is a correlation between systemic and pulmonary vascular remodelling in the overall population.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126946
url https://hdl.handle.net/2445/126946
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0152987
PLoS One, 2016, vol. 11, num. 4, p. e0152987
https://doi.org/10.1371/journal.pone.0152987
dc.rights.none.fl_str_mv cc-by (c) Muñoz Esquerre, Mariana et al., 2016
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Muñoz Esquerre, Mariana et al., 2016
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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