Big Pharma, little science?: A bibliometric perspective on Big Pharma's R&D decline

arXiv:1306.0947

Detalhes bibliográficos
Autores: Rafols, Ismael, Hopkins, Michael M., Hoekman, Jarno, Siepel, Josh, O'Hare, Alice, Perianes-Rodríguez, Antonio, Nightingale, Paul
Formato: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2014
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/106246
Acesso em linha:http://hdl.handle.net/10261/106246
Access Level:acceso abierto
Palavra-chave:Europe
Outsourcing
Pharmaceuticals
Globalisation
Research network
Innovation
Collaboration
Bibliometrics
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spelling Big Pharma, little science?: A bibliometric perspective on Big Pharma's R&D declineRafols, IsmaelHopkins, Michael M.Hoekman, JarnoSiepel, JoshO'Hare, AlicePerianes-Rodríguez, AntonioNightingale, PaulEuropeOutsourcingPharmaceuticalsGlobalisationResearch networkInnovationCollaborationBibliometricsarXiv:1306.0947There is a widespread perception that pharmaceutical R&D is facing a productivity crisis characterised by stagnation in the numbers of new drug approvals in the face of increasing R&D costs. This study explores pharmaceutical R&D dynamics by examining the publication activities of all R&D laboratories of the major European and US pharmaceutical firms (Big Pharma) during the period 1995-2009. The empirical findings present an industry in transformation. In the first place, we observe a decline of the total number of publications by large firms. Second, we show a relative increase of their external collaborations suggesting a tendency to outsource, and a diversification of the disciplinary base, in particular towards computation, health services and more clinical approaches. Also evident is a more pronounced decline in publications by both R&D laboratories located in Europe and by firms with European headquarters. Finally, while publications by Big Pharma in emerging economies sharply increase, they remain extremely low compared with those in developed countries. In summary, the trend in this transformation is one of a gradual decrease in internal research efforts and increasing reliance on external research. These empirical insights support the view that Big Pharma are increasingly becoming 'network integrators' rather than the prime locus of drug discovery. © 2012 Elsevier Inc.Ismael Rafols and Alice O'Hare were funded by the EU FP7 project FRIDA(Grant 225546, http://www.fridaproject.eu) and the US NSF (Award no. 0830207, http://idr.gatech.edu/). Michael Hopkins and Josh Siepel were supported by ESRC grant RES-360-25-0076. Jarno Hoekman has been supported by the Netherlands Organisation for Scientific Research (NWO) under the VIDI programme, number 452-06-005. Antonio Perianes-Rodríguez conducted his research at the University of Sussex as awardee of José Castillejo grant, JC2010-0042, funded by the Spanish Ministry of Education.Peer ReviewedElsevierEuropean CommissionNational Science Foundation (US)Economic and Social Research Council (UK)Netherlands Organization for Scientific ResearchUniversity of SussexMinisterio de Educación, Cultura y Deporte (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2014201420142014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Preprintinfo:eu-repo/semantics/submittedVersionhttp://hdl.handle.net/10261/106246reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/225546http://dx.doi.org/10.1016/j.techfore.2012.06.007Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1062462026-05-22T06:33:51Z
dc.title.none.fl_str_mv Big Pharma, little science?: A bibliometric perspective on Big Pharma's R&D decline
title Big Pharma, little science?: A bibliometric perspective on Big Pharma's R&D decline
spellingShingle Big Pharma, little science?: A bibliometric perspective on Big Pharma's R&D decline
Rafols, Ismael
Europe
Outsourcing
Pharmaceuticals
Globalisation
Research network
Innovation
Collaboration
Bibliometrics
title_short Big Pharma, little science?: A bibliometric perspective on Big Pharma's R&D decline
title_full Big Pharma, little science?: A bibliometric perspective on Big Pharma's R&D decline
title_fullStr Big Pharma, little science?: A bibliometric perspective on Big Pharma's R&D decline
title_full_unstemmed Big Pharma, little science?: A bibliometric perspective on Big Pharma's R&D decline
title_sort Big Pharma, little science?: A bibliometric perspective on Big Pharma's R&D decline
dc.creator.none.fl_str_mv Rafols, Ismael
Hopkins, Michael M.
Hoekman, Jarno
Siepel, Josh
O'Hare, Alice
Perianes-Rodríguez, Antonio
Nightingale, Paul
author Rafols, Ismael
author_facet Rafols, Ismael
Hopkins, Michael M.
Hoekman, Jarno
Siepel, Josh
O'Hare, Alice
Perianes-Rodríguez, Antonio
Nightingale, Paul
author_role author
author2 Hopkins, Michael M.
Hoekman, Jarno
Siepel, Josh
O'Hare, Alice
Perianes-Rodríguez, Antonio
Nightingale, Paul
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
National Science Foundation (US)
Economic and Social Research Council (UK)
Netherlands Organization for Scientific Research
University of Sussex
Ministerio de Educación, Cultura y Deporte (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Europe
Outsourcing
Pharmaceuticals
Globalisation
Research network
Innovation
Collaboration
Bibliometrics
topic Europe
Outsourcing
Pharmaceuticals
Globalisation
Research network
Innovation
Collaboration
Bibliometrics
description arXiv:1306.0947
publishDate 2014
dc.date.none.fl_str_mv 2014
2014
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Preprint
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/106246
url http://hdl.handle.net/10261/106246
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/225546
http://dx.doi.org/10.1016/j.techfore.2012.06.007
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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