Dairy consumption and incidence of breast cancer in the ‘Seguimiento Universidad de Navarra’ (SUN) project
Dairy products might influence breast cancer (BC) risk. However, evidence is inconsistent. We sought to examine the association between dairy product consumption-and their subtypes-and incident BC in a Mediterranean cohort. The SUN ("Seguimiento Universidad de Navarra") Project is a Spanis...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/114958 |
| Acceso en línea: | https://hdl.handle.net/10171/114958 |
| Access Level: | acceso abierto |
| Palabra clave: | Mediterranean population SUN cohort Breast cancer Dairy products |
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Dairy consumption and incidence of breast cancer in the ‘Seguimiento Universidad de Navarra’ (SUN) projectAguilera-Buenosvinos, I. (Inmaculada)|||/items/6218c9f5-cbcd-420f-afe7-5c070b7c7fb0Fernández-Lázaro, C.I. (César Ignacio)|||/items/7733df60-158c-4de1-a1df-bc693f6f1f40Romanos-Nanclares, A. (Andrea)|||/items/11d87df0-9d0e-4a4b-bffe-b71ef4c6e5c0Gea, A. (Alfredo)|||/items/0fc6850b-e4e0-4795-960d-db184cd1385fSanchez-Bayona, R. (Rodrigo)|||/items/87f95f8a-7474-40d8-9ac8-14ee3c1cc6baMartin-Moreno, J.M. (J.M.)|||/items/acdc4916-e77f-45d4-921d-c2dfccbda1fcMartínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0Mediterranean populationSUN cohortBreast cancerDairy productsDairy products might influence breast cancer (BC) risk. However, evidence is inconsistent. We sought to examine the association between dairy product consumption-and their subtypes-and incident BC in a Mediterranean cohort. The SUN ("Seguimiento Universidad de Navarra") Project is a Spanish dynamic ongoing cohort of university graduates. Dairy product consumption was estimated through a previously validated 136-item food frequency questionnaire (FFQ). Incident BC was reported in biennial follow-up questionnaires and confirmed with revision of medical records and consultation of the National Death Index. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated with Cox regression models. Among 123,297 women-years of follow-up (10,930 women, median follow-up 12.1 years), we confirmed 119 incident BC cases. We found a nonlinear association between total dairy product consumption and BC incidence (pnonlinear = 0.048) and a significant inverse association for women with moderate total dairy product consumption (HRQ2vs.Q1 = 0.49 (95% CI 0.28-0.84); HRQ3vs.Q1 = 0.49 (95% CI 0.29-0.84) ptrend = 0.623) and with moderate low-fat dairy product consumption (HRQ2vs.Q1 = 0.58 (95% CI 0.35-0.97); HRQ3vs.Q1 = 0.55 (95% CI 0.32-0.92), ptrend = 0.136). In stratified analyses, we found a significant inverse association between intermediate low-fat dairy product consumption and premenopausal BC and between medium total dairy product consumption and postmenopausal BC. Thus, dairy products, especially low-fat dairy products, may be considered within overall prudent dietary patterns.MDPIDadun. Depósito Académico Digital Universidad de Navarra20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/114958reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1149582026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Dairy consumption and incidence of breast cancer in the ‘Seguimiento Universidad de Navarra’ (SUN) project |
| title |
Dairy consumption and incidence of breast cancer in the ‘Seguimiento Universidad de Navarra’ (SUN) project |
| spellingShingle |
Dairy consumption and incidence of breast cancer in the ‘Seguimiento Universidad de Navarra’ (SUN) project Aguilera-Buenosvinos, I. (Inmaculada)|||/items/6218c9f5-cbcd-420f-afe7-5c070b7c7fb0 Mediterranean population SUN cohort Breast cancer Dairy products |
| title_short |
Dairy consumption and incidence of breast cancer in the ‘Seguimiento Universidad de Navarra’ (SUN) project |
| title_full |
Dairy consumption and incidence of breast cancer in the ‘Seguimiento Universidad de Navarra’ (SUN) project |
| title_fullStr |
Dairy consumption and incidence of breast cancer in the ‘Seguimiento Universidad de Navarra’ (SUN) project |
| title_full_unstemmed |
Dairy consumption and incidence of breast cancer in the ‘Seguimiento Universidad de Navarra’ (SUN) project |
| title_sort |
Dairy consumption and incidence of breast cancer in the ‘Seguimiento Universidad de Navarra’ (SUN) project |
| dc.creator.none.fl_str_mv |
Aguilera-Buenosvinos, I. (Inmaculada)|||/items/6218c9f5-cbcd-420f-afe7-5c070b7c7fb0 Fernández-Lázaro, C.I. (César Ignacio)|||/items/7733df60-158c-4de1-a1df-bc693f6f1f40 Romanos-Nanclares, A. (Andrea)|||/items/11d87df0-9d0e-4a4b-bffe-b71ef4c6e5c0 Gea, A. (Alfredo)|||/items/0fc6850b-e4e0-4795-960d-db184cd1385f Sanchez-Bayona, R. (Rodrigo)|||/items/87f95f8a-7474-40d8-9ac8-14ee3c1cc6ba Martin-Moreno, J.M. (J.M.)|||/items/acdc4916-e77f-45d4-921d-c2dfccbda1fc Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 |
| author |
Aguilera-Buenosvinos, I. (Inmaculada)|||/items/6218c9f5-cbcd-420f-afe7-5c070b7c7fb0 |
| author_facet |
Aguilera-Buenosvinos, I. (Inmaculada)|||/items/6218c9f5-cbcd-420f-afe7-5c070b7c7fb0 Fernández-Lázaro, C.I. (César Ignacio)|||/items/7733df60-158c-4de1-a1df-bc693f6f1f40 Romanos-Nanclares, A. (Andrea)|||/items/11d87df0-9d0e-4a4b-bffe-b71ef4c6e5c0 Gea, A. (Alfredo)|||/items/0fc6850b-e4e0-4795-960d-db184cd1385f Sanchez-Bayona, R. (Rodrigo)|||/items/87f95f8a-7474-40d8-9ac8-14ee3c1cc6ba Martin-Moreno, J.M. (J.M.)|||/items/acdc4916-e77f-45d4-921d-c2dfccbda1fc Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 |
| author_role |
author |
| author2 |
Fernández-Lázaro, C.I. (César Ignacio)|||/items/7733df60-158c-4de1-a1df-bc693f6f1f40 Romanos-Nanclares, A. (Andrea)|||/items/11d87df0-9d0e-4a4b-bffe-b71ef4c6e5c0 Gea, A. (Alfredo)|||/items/0fc6850b-e4e0-4795-960d-db184cd1385f Sanchez-Bayona, R. (Rodrigo)|||/items/87f95f8a-7474-40d8-9ac8-14ee3c1cc6ba Martin-Moreno, J.M. (J.M.)|||/items/acdc4916-e77f-45d4-921d-c2dfccbda1fc Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Mediterranean population SUN cohort Breast cancer Dairy products |
| topic |
Mediterranean population SUN cohort Breast cancer Dairy products |
| description |
Dairy products might influence breast cancer (BC) risk. However, evidence is inconsistent. We sought to examine the association between dairy product consumption-and their subtypes-and incident BC in a Mediterranean cohort. The SUN ("Seguimiento Universidad de Navarra") Project is a Spanish dynamic ongoing cohort of university graduates. Dairy product consumption was estimated through a previously validated 136-item food frequency questionnaire (FFQ). Incident BC was reported in biennial follow-up questionnaires and confirmed with revision of medical records and consultation of the National Death Index. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated with Cox regression models. Among 123,297 women-years of follow-up (10,930 women, median follow-up 12.1 years), we confirmed 119 incident BC cases. We found a nonlinear association between total dairy product consumption and BC incidence (pnonlinear = 0.048) and a significant inverse association for women with moderate total dairy product consumption (HRQ2vs.Q1 = 0.49 (95% CI 0.28-0.84); HRQ3vs.Q1 = 0.49 (95% CI 0.29-0.84) ptrend = 0.623) and with moderate low-fat dairy product consumption (HRQ2vs.Q1 = 0.58 (95% CI 0.35-0.97); HRQ3vs.Q1 = 0.55 (95% CI 0.32-0.92), ptrend = 0.136). In stratified analyses, we found a significant inverse association between intermediate low-fat dairy product consumption and premenopausal BC and between medium total dairy product consumption and postmenopausal BC. Thus, dairy products, especially low-fat dairy products, may be considered within overall prudent dietary patterns. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/114958 |
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https://hdl.handle.net/10171/114958 |
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Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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15.81155 |