SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism

The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by the lack of fluorescent chemical structures that allow direct monitoring of small metabolites under physiological conditions with high spati...

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Detalles Bibliográficos
Autores: Benson, Sam, Fernandez, Antonio, Barth, Nicole D., de Moliner, Fabio, Horrocks, Mathew H., Herrington, C. Simon, Abad, José Luis, Delgado Cirilo, Antonio, Kelly, Lisa, Chang, Ziyuan, Feng, Yi, Nishiure, Miyako, Hori, Yuichiro, Kikuchi, Kazuya, Vendrell, Marc
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/171908
Acceso en línea:https://hdl.handle.net/2445/171908
Access Level:acceso abierto
Palabra clave:Metabòlits
Cèl·lules canceroses
Motilitat cel·lular
Metabolites
Cancer cells
Cell motility
Descripción
Sumario:The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by the lack of fluorescent chemical structures that allow direct monitoring of small metabolites under physiological conditions with high spatial and temporal resolution. Herein, we describe SCOTfluors as novel small‐sized multi‐colored fluorophores for real‐time tracking of essential metabolites in live cells and in vivo and for the acquisition of metabolic profiles from human cancer cells of variable origin.

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